UniProtKB - Q2MHN3 (ZFHX2_MOUSE)
Protein
Zinc finger homeobox protein 2
Gene
Zfhx2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 446 – 469 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 501 – 525 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 752 – 776 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 815 – 839 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 864 – 888 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1003 – 1026 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1185 – 1211 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1242 – 1266 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1474 – 1497 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 1589 – 1648 | Homeobox 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 1664 – 1687 | C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1761 – 1783 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
DNA bindingi | 1851 – 1910 | Homeobox 2PROSITE-ProRule annotationAdd BLAST | 60 | |
DNA bindingi | 2058 – 2117 | Homeobox 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 2441 – 2461 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 2485 – 2509 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- adult behavior Source: MGI
- brain development Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription, DNA-templated Source: GO_Central
- regulation of neuron differentiation Source: GO_Central
- regulation of sensory perception of pain Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger homeobox protein 2Alternative name(s): Zinc finger homeodomain protein 51 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2686934, Zfhx2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Knockout mice exhibit a range of subtle behavioral abnormalities. Locomotor activity is generally increased, but only in familiar environments. There is a slight increase in depression-like behavior, most notably increased immobility in the tail suspension test. Assays of anxiety-like behavior give conflicting results; the open field test indicates a slight reduction in anxiety-like behavior whereas other tests show no significant behavioral changes (PubMed:23300874). Knockout mice are hyposensitive to noxious mechanical stimuli applied to the tail and hypersensitive to noxious heat (PubMed:29253101).2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1907 | R → K: Results in hyposensitivity to noxious heat. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000443288 | 1 – 2562 | Zinc finger homeobox protein 2Add BLAST | 2562 |
Proteomic databases
MaxQBi | Q2MHN3 |
PaxDbi | Q2MHN3 |
PeptideAtlasi | Q2MHN3 |
PRIDEi | Q2MHN3 |
PTM databases
iPTMneti | Q2MHN3 |
PhosphoSitePlusi | Q2MHN3 |
Expressioni
Tissue specificityi
Expressed in brain (at protein level) (PubMed:23300874). Expressed at the highest levels in the pyramidal cell layer of the hippocampus, the suprachiasmatic nucleus, laterodorsal thalamic nucleus, lateral geniculate nucleus, substantia nigra pars compacta, and magnocellular part of the red nucleus (at protein level) (PubMed:23300874). Highly expressed in dorsal root ganglia (PubMed:29253101). Expressed at lower levels in kidney, stomach, liver, heart and testis (PubMed:16257534, PubMed:23300874).3 Publications
Developmental stagei
Detected at 11.5 days post coitum (dpc) in developing brain, and continues to be expressed all the way through to postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534).2 Publications
Inductioni
Expression in specific regions of the developing brain is negatively regulated by its antisense mRNA. In particular, down-regulated in pyramidal and granule cells in the hippocampus during early differentiation and the migration stage.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040721, Expressed in cerebellar cortex and 133 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045156 |
Miscellaneous databases
RNActi | Q2MHN3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 599 – 708 | Pro-richPROSITE-ProRule annotationAdd BLAST | 110 | |
Compositional biasi | 1053 – 1125 | Pro-richPROSITE-ProRule annotationAdd BLAST | 73 | |
Compositional biasi | 1305 – 1465 | Pro-richPROSITE-ProRule annotationAdd BLAST | 161 | |
Compositional biasi | 1522 – 1550 | Pro-richPROSITE-ProRule annotationAdd BLAST | 29 | |
Compositional biasi | 1693 – 1751 | Glu-richPROSITE-ProRule annotationAdd BLAST | 59 | |
Compositional biasi | 1921 – 2011 | Pro-richPROSITE-ProRule annotationAdd BLAST | 91 | |
Compositional biasi | 2186 – 2412 | Pro-richPROSITE-ProRule annotationAdd BLAST | 227 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 446 – 469 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 501 – 525 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 752 – 776 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 815 – 839 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 864 – 888 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1003 – 1026 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1185 – 1211 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1242 – 1266 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1474 – 1497 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1664 – 1687 | C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1761 – 1783 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 2441 – 2461 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 2485 – 2509 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1146, Eukaryota |
GeneTreei | ENSGT00940000160537 |
HOGENOMi | CLU_001401_1_0_1 |
InParanoidi | Q2MHN3 |
OMAi | TVFCCPY |
OrthoDBi | 15351at2759 |
PhylomeDBi | Q2MHN3 |
TreeFami | TF323288 |
Family and domain databases
CDDi | cd00086, homeodomain, 3 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR027028, ZFHX2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45891:SF1, PTHR45891:SF1, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 3 hits |
SMARTi | View protein in SMART SM00389, HOX, 3 hits SM00355, ZnF_C2H2, 15 hits SM00451, ZnF_U1, 7 hits |
SUPFAMi | SSF46689, SSF46689, 3 hits SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 3 hits PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
Q2MHN3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLNSASPS GTVPSPGHNV RSPPPETSSS STSDPVTKDP PDAPSTSESI
60 70 80 90 100
RSSEPGGERL ESGSDLDPPK EIGEPQEEPG CGHIPPKDLG VAKEEEEILP
110 120 130 140 150
LDLSSHLFFA AGGQAYLLAN LPLPRGSELS LPKGFPWDEA SAKEEPSLPL
160 170 180 190 200
LTHFPSSHLT TLHIQHGFDP IQGFSSSDQM LSHDTSAPSL AACERRDGSF
210 220 230 240 250
WSYQLVPNPT EDPKDGPLGS RREDHRAMFW ICLLCRLGFG RLQTFIGHTL
260 270 280 290 300
SHGVKLSPAH HQGLLGSPAV LQEGHDGGMA LLSFLEPKFL TRPSPEVPDT
310 320 330 340 350
STVTVKTNGA QAEDGPPEAD GQALVLPAEE VIALSPPSPP TALATWDPSP
360 370 380 390 400
TQAKDSPVPR GEAGPDWFPE GQEEDGGLCL PLNQSSPTSK EVAVLPAPAG
410 420 430 440 450
SPEDTSDPPP SCRLADDYTP APAAFQGLSL SSHMSLLHSR NSCKTLKCPK
460 470 480 490 500
CNWHYKYQQT LDVHMREKHP ESNSHCSYCS AGGAHPRLAR GESYNCGYKP
510 520 530 540 550
YRCDVCNYST TTKGNLSIHM QSDKHLANLQ GFQAGPGGQA SPPEASLPPT
560 570 580 590 600
SVGDKEPKTK SSWQCKVCSY ETNISRNLRI HMTSEKHMQN VLMLHQGLPL
610 620 630 640 650
GLPPGLVGPG PPPPPGAAPT NPPELFQYFG PQALGQPQTP MPGPGLRPDK
660 670 680 690 700
PLEAQLLLNG FHHLGAPARK FPTAAPGSLS PETHLPPSQL LGSSSDGLPT
710 720 730 740 750
SPSPDDSPAL KVFRCLVCQA FSTDSLELLL YHCSIGRSLP EAEWKEVAGD
760 770 780 790 800
THRCKLCCYG TQLKANFQLH LKTDKHTQKY QLAAHLREGG GAMGTPSLLA
810 820 830 840 850
LGDGASYGSI SPLHLRCNIC DFESNSKEKM QLHTRGSAHE ENSQIYKFLL
860 870 880 890 900
EMEGAEAGPE PGLYHCLLCA WDTPSRLALL QHLRTPAHRD AQAQRRLQLL
910 920 930 940 950
QNGPAAEEGL SALQSILSFS HGRLQTPGKA SDTPLAQPPT SEKDAQNKTE
960 970 980 990 1000
QQASEVTEDR SGPPRDSANQ ITVFCCPYCS FLSPECDQVR VHTLSQHAVQ
1010 1020 1030 1040 1050
PKYRCPLCQE QLVGRPALHF HLSHLHNVVP ECVEKLLLVA TTVEMTFATK
1060 1070 1080 1090 1100
MLPGPTLNPV EDGLDHPAPG AEPTPNRDQV AESSNLAPEV SPDPPLEPPL
1110 1120 1130 1140 1150
APVEGSREPS ESPDQPPSPA PSPAPRLDAQ VEELAPLPTM SEEEEGAMGE
1160 1170 1180 1190 1200
PRSAEPTPAD SRHPLTYRKT TNFALDKFLD PARPYKCTVC KESFTQKNIL
1210 1220 1230 1240 1250
LVHYNSVSHL HKMKKAAIDP SGPARGEAGI PPPAATASDK PFKCTVCRVS
1260 1270 1280 1290 1300
YNQSSTLEIH MRSVLHQTRS RGAKIDARAE GAERGQEEFK EGETEGEAGT
1310 1320 1330 1340 1350
EKKGPDPGGF MSGLPFLSPP PPPLDLHRFS APLFTPPVLP PFPLVPESLL
1360 1370 1380 1390 1400
KLQQQQLLLP FYLHDLKVGP KLALASPTPM LSLPAANPPP LPAPPKAELA
1410 1420 1430 1440 1450
EQEWERPLMA EEGTEAGPSS PTHTSPNEAA RTAAKALLEN FGFELVIQYN
1460 1470 1480 1490 1500
EGKQAVPPPP TPPPPESLGG GDKLACGACG KLFSNMLILK THEEHVHRRF
1510 1520 1530 1540 1550
LPFEALSRYA AQFRKSYDSL YPPPVEPPKP PDGCLESPPQ LGPPFVVPEP
1560 1570 1580 1590 1600
EVGGIHTSEE RSLSGGGPWP SEEEEGSRGS LPPAVPVGRR FSRTKFTEFQ
1610 1620 1630 1640 1650
TQALQSFFET SAYPKDGEVE RLASLLGLAS RVVVVWFQNA RQKARKNACE
1660 1670 1680 1690 1700
GGPVTAGGAS GGASGCRRCH ATFACVFELV RHLKKCYDDQ PPEEEEEAER
1710 1720 1730 1740 1750
GEEEEEVEEE EAEERNLEPA AARPGGPSPE HADGEDLSQT EPTRPESKES
1760 1770 1780 1790 1800
EGKAPPSPPV YACDQCAASF PSQDLLTTHH RLHLLPSVQP SAPPPSQLLD
1810 1820 1830 1840 1850
LPLLVFGERN PVVSGTSSVT GTPLKRKHDD GSLSPTGSEA GGGGEGEPPK
1860 1870 1880 1890 1900
DKRLRTTILP EQLEILYRWY MQDSNPTRKM LDCISEEVGL KKRVVQVWFQ
1910 1920 1930 1940 1950
NTRARERKGQ FRSTPGGVAG PAVKPTVPPS PAPFPKFNLL LSKIEDETGK
1960 1970 1980 1990 2000
EAPKRDAPAF PYPTVTPAVG PLPFLPPGKE AAVPTPEPPP PLPPPALSED
2010 2020 2030 2040 2050
EGPEEPSKAS PESEACSPSA GDLSDSSASS LAEPESPGAG GTSGGPGGGT
2060 2070 2080 2090 2100
GVPDSMGQRR YRTQMSSLQL KIMKACYEAY RTPTMQECEV LGEEIGLPKR
2110 2120 2130 2140 2150
VIQVWFQNAR AKEKKAKLQG TAPPGSGGSS EGTSAAQRTD CPYCDVKYDF
2160 2170 2180 2190 2200
YVSCRGHLFS RQHLAKLKEA VRAQLKSESK CYDLAPAPET PLAPKGPPAT
2210 2220 2230 2240 2250
TPASSVPLGA SPTLPRLAPV LLPGPTLAQP PLGSIASFNS GPAASSGLLG
2260 2270 2280 2290 2300
LATSVLPATT VVQTAGPGRP LPQRPVSNQT NSSTDPTPGP ATEPSGDKVS
2310 2320 2330 2340 2350
GERKPVATLP NSSTDALKNL KALKATVPAL LGGQFLPFPL PPAGGAAPPA
2360 2370 2380 2390 2400
VFGPQLQGAY FQQLYGMKKG LFPMNPVIPQ TLIGLLPNAL LQQPPQAPEP
2410 2420 2430 2440 2450
TATAPPKPPE LPASGEGESS EADELLTGST GISTVDVTHR YLCRQCKMAF
2460 2470 2480 2490 2500
DGEAPATAHQ RSFCFFGRGS GASMPAPLRV PICTYHCLAC EVLLSGREAL
2510 2520 2530 2540 2550
ASHLRSSAHR RKAAPPPGGP PITVTNSATA VPAAVAFAKE EARLPHTDPN
2560
PKTTTTSTLL AL
Sequence cautioni
The sequence BAD90426 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | V → I in BAD90426 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB190186 mRNA Translation: BAE78491.1 AC157212 Genomic DNA No translation available. AK220366 mRNA Translation: BAD90426.1 Different initiation. BC050052 mRNA Translation: AAH50052.1 |
CCDSi | CCDS27107.1 |
RefSeqi | NP_001034287.1, NM_001039198.1 XP_006519044.1, XM_006518981.3 |
Genome annotation databases
Ensembli | ENSMUST00000036328; ENSMUSP00000045156; ENSMUSG00000040721 |
GeneIDi | 239102 |
KEGGi | mmu:239102 |
UCSCi | uc007txz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB190186 mRNA Translation: BAE78491.1 AC157212 Genomic DNA No translation available. AK220366 mRNA Translation: BAD90426.1 Different initiation. BC050052 mRNA Translation: AAH50052.1 |
CCDSi | CCDS27107.1 |
RefSeqi | NP_001034287.1, NM_001039198.1 XP_006519044.1, XM_006518981.3 |
3D structure databases
SMRi | Q2MHN3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045156 |
PTM databases
iPTMneti | Q2MHN3 |
PhosphoSitePlusi | Q2MHN3 |
Proteomic databases
MaxQBi | Q2MHN3 |
PaxDbi | Q2MHN3 |
PeptideAtlasi | Q2MHN3 |
PRIDEi | Q2MHN3 |
Protocols and materials databases
Antibodypediai | 51729, 41 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000036328; ENSMUSP00000045156; ENSMUSG00000040721 |
GeneIDi | 239102 |
KEGGi | mmu:239102 |
UCSCi | uc007txz.1, mouse |
Organism-specific databases
CTDi | 85446 |
MGIi | MGI:2686934, Zfhx2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1146, Eukaryota |
GeneTreei | ENSGT00940000160537 |
HOGENOMi | CLU_001401_1_0_1 |
InParanoidi | Q2MHN3 |
OMAi | TVFCCPY |
OrthoDBi | 15351at2759 |
PhylomeDBi | Q2MHN3 |
TreeFami | TF323288 |
Miscellaneous databases
BioGRID-ORCSi | 239102, 2 hits in 17 CRISPR screens |
ChiTaRSi | Zfhx2, mouse |
PROi | PR:Q2MHN3 |
RNActi | Q2MHN3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040721, Expressed in cerebellar cortex and 133 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 3 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR027028, ZFHX2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45891:SF1, PTHR45891:SF1, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 3 hits |
SMARTi | View protein in SMART SM00389, HOX, 3 hits SM00355, ZnF_C2H2, 15 hits SM00451, ZnF_U1, 7 hits |
SUPFAMi | SSF46689, SSF46689, 3 hits SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 3 hits PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFHX2_MOUSE | |
Accessioni | Q2MHN3Primary (citable) accession number: Q2MHN3 Secondary accession number(s): Q5DU04, Q80VJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2018 |
Last sequence update: | February 21, 2006 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot