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UniProtKB - Q2MHN3 (ZFHX2_MOUSE)

Entry version 129 (02 Dec 2020)
Sequence version 1 (21 Feb 2006)
Previous versions | rss
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Protein

Zinc finger homeobox protein 2

Gene

Zfhx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri446 – 469C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri501 – 525C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri752 – 776C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri815 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri864 – 888C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1003 – 1026C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1185 – 1211C2H2-type 7PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1242 – 1266C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1474 – 1497C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1589 – 1648Homeobox 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri1664 – 1687C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1761 – 1783C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
DNA bindingi1851 – 1910Homeobox 2PROSITE-ProRule annotationAdd BLAST60
DNA bindingi2058 – 2117Homeobox 3PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2441 – 2461C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri2485 – 2509C2H2-type 13PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger homeobox protein 2
Alternative name(s):
Zinc finger homeodomain protein 51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfhx2Imported
Synonyms:Kiaa1056Imported, zfh-51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2686934, Zfhx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice exhibit a range of subtle behavioral abnormalities. Locomotor activity is generally increased, but only in familiar environments. There is a slight increase in depression-like behavior, most notably increased immobility in the tail suspension test. Assays of anxiety-like behavior give conflicting results; the open field test indicates a slight reduction in anxiety-like behavior whereas other tests show no significant behavioral changes (PubMed:23300874). Knockout mice are hyposensitive to noxious mechanical stimuli applied to the tail and hypersensitive to noxious heat (PubMed:29253101).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1907R → K: Results in hyposensitivity to noxious heat. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004432881 – 2562Zinc finger homeobox protein 2Add BLAST2562

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2MHN3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2MHN3

PeptideAtlas

More...PeptideAtlasi		Q2MHN3

PRoteomics IDEntifications database

More...PRIDEi		Q2MHN3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2MHN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2MHN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain (at protein level) (PubMed:23300874). Expressed at the highest levels in the pyramidal cell layer of the hippocampus, the suprachiasmatic nucleus, laterodorsal thalamic nucleus, lateral geniculate nucleus, substantia nigra pars compacta, and magnocellular part of the red nucleus (at protein level) (PubMed:23300874). Highly expressed in dorsal root ganglia (PubMed:29253101). Expressed at lower levels in kidney, stomach, liver, heart and testis (PubMed:16257534, PubMed:23300874).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 11.5 days post coitum (dpc) in developing brain, and continues to be expressed all the way through to postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression in specific regions of the developing brain is negatively regulated by its antisense mRNA. In particular, down-regulated in pyramidal and granule cells in the hippocampus during early differentiation and the migration stage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040721, Expressed in cerebellar cortex and 133 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000045156

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2MHN3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2MHN3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi599 – 708Pro-richPROSITE-ProRule annotationAdd BLAST110
Compositional biasi1053 – 1125Pro-richPROSITE-ProRule annotationAdd BLAST73
Compositional biasi1305 – 1465Pro-richPROSITE-ProRule annotationAdd BLAST161
Compositional biasi1522 – 1550Pro-richPROSITE-ProRule annotationAdd BLAST29
Compositional biasi1693 – 1751Glu-richPROSITE-ProRule annotationAdd BLAST59
Compositional biasi1921 – 2011Pro-richPROSITE-ProRule annotationAdd BLAST91
Compositional biasi2186 – 2412Pro-richPROSITE-ProRule annotationAdd BLAST227

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri446 – 469C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri501 – 525C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri752 – 776C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri815 – 839C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri864 – 888C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1003 – 1026C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1185 – 1211C2H2-type 7PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1242 – 1266C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1474 – 1497C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1664 – 1687C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1761 – 1783C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2441 – 2461C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri2485 – 2509C2H2-type 13PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1146, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001401_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2MHN3

Identification of Orthologs from Complete Genome Data

More...OMAi		TVFCCPY

Database of Orthologous Groups

More...OrthoDBi		15351at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2MHN3

TreeFam database of animal gene trees

More...TreeFami		TF323288

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR027028, ZFHX2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR45891:SF1, PTHR45891:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 3 hits
SM00355, ZnF_C2H2, 15 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 3 hits
SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2MHN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLNSASPS GTVPSPGHNV RSPPPETSSS STSDPVTKDP PDAPSTSESI 
        60         70         80         90        100
RSSEPGGERL ESGSDLDPPK EIGEPQEEPG CGHIPPKDLG VAKEEEEILP 
       110        120        130        140        150
LDLSSHLFFA AGGQAYLLAN LPLPRGSELS LPKGFPWDEA SAKEEPSLPL 
       160        170        180        190        200
LTHFPSSHLT TLHIQHGFDP IQGFSSSDQM LSHDTSAPSL AACERRDGSF 
       210        220        230        240        250
WSYQLVPNPT EDPKDGPLGS RREDHRAMFW ICLLCRLGFG RLQTFIGHTL 
       260        270        280        290        300
SHGVKLSPAH HQGLLGSPAV LQEGHDGGMA LLSFLEPKFL TRPSPEVPDT 
       310        320        330        340        350
STVTVKTNGA QAEDGPPEAD GQALVLPAEE VIALSPPSPP TALATWDPSP 
       360        370        380        390        400
TQAKDSPVPR GEAGPDWFPE GQEEDGGLCL PLNQSSPTSK EVAVLPAPAG 
       410        420        430        440        450
SPEDTSDPPP SCRLADDYTP APAAFQGLSL SSHMSLLHSR NSCKTLKCPK 
       460        470        480        490        500
CNWHYKYQQT LDVHMREKHP ESNSHCSYCS AGGAHPRLAR GESYNCGYKP 
       510        520        530        540        550
YRCDVCNYST TTKGNLSIHM QSDKHLANLQ GFQAGPGGQA SPPEASLPPT 
       560        570        580        590        600
SVGDKEPKTK SSWQCKVCSY ETNISRNLRI HMTSEKHMQN VLMLHQGLPL 
       610        620        630        640        650
GLPPGLVGPG PPPPPGAAPT NPPELFQYFG PQALGQPQTP MPGPGLRPDK 
       660        670        680        690        700
PLEAQLLLNG FHHLGAPARK FPTAAPGSLS PETHLPPSQL LGSSSDGLPT 
       710        720        730        740        750
SPSPDDSPAL KVFRCLVCQA FSTDSLELLL YHCSIGRSLP EAEWKEVAGD 
       760        770        780        790        800
THRCKLCCYG TQLKANFQLH LKTDKHTQKY QLAAHLREGG GAMGTPSLLA 
       810        820        830        840        850
LGDGASYGSI SPLHLRCNIC DFESNSKEKM QLHTRGSAHE ENSQIYKFLL 
       860        870        880        890        900
EMEGAEAGPE PGLYHCLLCA WDTPSRLALL QHLRTPAHRD AQAQRRLQLL 
       910        920        930        940        950
QNGPAAEEGL SALQSILSFS HGRLQTPGKA SDTPLAQPPT SEKDAQNKTE 
       960        970        980        990       1000
QQASEVTEDR SGPPRDSANQ ITVFCCPYCS FLSPECDQVR VHTLSQHAVQ 
      1010       1020       1030       1040       1050
PKYRCPLCQE QLVGRPALHF HLSHLHNVVP ECVEKLLLVA TTVEMTFATK 
      1060       1070       1080       1090       1100
MLPGPTLNPV EDGLDHPAPG AEPTPNRDQV AESSNLAPEV SPDPPLEPPL 
      1110       1120       1130       1140       1150
APVEGSREPS ESPDQPPSPA PSPAPRLDAQ VEELAPLPTM SEEEEGAMGE 
      1160       1170       1180       1190       1200
PRSAEPTPAD SRHPLTYRKT TNFALDKFLD PARPYKCTVC KESFTQKNIL 
      1210       1220       1230       1240       1250
LVHYNSVSHL HKMKKAAIDP SGPARGEAGI PPPAATASDK PFKCTVCRVS 
      1260       1270       1280       1290       1300
YNQSSTLEIH MRSVLHQTRS RGAKIDARAE GAERGQEEFK EGETEGEAGT 
      1310       1320       1330       1340       1350
EKKGPDPGGF MSGLPFLSPP PPPLDLHRFS APLFTPPVLP PFPLVPESLL 
      1360       1370       1380       1390       1400
KLQQQQLLLP FYLHDLKVGP KLALASPTPM LSLPAANPPP LPAPPKAELA 
      1410       1420       1430       1440       1450
EQEWERPLMA EEGTEAGPSS PTHTSPNEAA RTAAKALLEN FGFELVIQYN 
      1460       1470       1480       1490       1500
EGKQAVPPPP TPPPPESLGG GDKLACGACG KLFSNMLILK THEEHVHRRF 
      1510       1520       1530       1540       1550
LPFEALSRYA AQFRKSYDSL YPPPVEPPKP PDGCLESPPQ LGPPFVVPEP 
      1560       1570       1580       1590       1600
EVGGIHTSEE RSLSGGGPWP SEEEEGSRGS LPPAVPVGRR FSRTKFTEFQ 
      1610       1620       1630       1640       1650
TQALQSFFET SAYPKDGEVE RLASLLGLAS RVVVVWFQNA RQKARKNACE 
      1660       1670       1680       1690       1700
GGPVTAGGAS GGASGCRRCH ATFACVFELV RHLKKCYDDQ PPEEEEEAER 
      1710       1720       1730       1740       1750
GEEEEEVEEE EAEERNLEPA AARPGGPSPE HADGEDLSQT EPTRPESKES 
      1760       1770       1780       1790       1800
EGKAPPSPPV YACDQCAASF PSQDLLTTHH RLHLLPSVQP SAPPPSQLLD 
      1810       1820       1830       1840       1850
LPLLVFGERN PVVSGTSSVT GTPLKRKHDD GSLSPTGSEA GGGGEGEPPK 
      1860       1870       1880       1890       1900
DKRLRTTILP EQLEILYRWY MQDSNPTRKM LDCISEEVGL KKRVVQVWFQ 
      1910       1920       1930       1940       1950
NTRARERKGQ FRSTPGGVAG PAVKPTVPPS PAPFPKFNLL LSKIEDETGK 
      1960       1970       1980       1990       2000
EAPKRDAPAF PYPTVTPAVG PLPFLPPGKE AAVPTPEPPP PLPPPALSED 
      2010       2020       2030       2040       2050
EGPEEPSKAS PESEACSPSA GDLSDSSASS LAEPESPGAG GTSGGPGGGT 
      2060       2070       2080       2090       2100
GVPDSMGQRR YRTQMSSLQL KIMKACYEAY RTPTMQECEV LGEEIGLPKR 
      2110       2120       2130       2140       2150
VIQVWFQNAR AKEKKAKLQG TAPPGSGGSS EGTSAAQRTD CPYCDVKYDF 
      2160       2170       2180       2190       2200
YVSCRGHLFS RQHLAKLKEA VRAQLKSESK CYDLAPAPET PLAPKGPPAT 
      2210       2220       2230       2240       2250
TPASSVPLGA SPTLPRLAPV LLPGPTLAQP PLGSIASFNS GPAASSGLLG 
      2260       2270       2280       2290       2300
LATSVLPATT VVQTAGPGRP LPQRPVSNQT NSSTDPTPGP ATEPSGDKVS 
      2310       2320       2330       2340       2350
GERKPVATLP NSSTDALKNL KALKATVPAL LGGQFLPFPL PPAGGAAPPA 
      2360       2370       2380       2390       2400
VFGPQLQGAY FQQLYGMKKG LFPMNPVIPQ TLIGLLPNAL LQQPPQAPEP 
      2410       2420       2430       2440       2450
TATAPPKPPE LPASGEGESS EADELLTGST GISTVDVTHR YLCRQCKMAF 
      2460       2470       2480       2490       2500
DGEAPATAHQ RSFCFFGRGS GASMPAPLRV PICTYHCLAC EVLLSGREAL 
      2510       2520       2530       2540       2550
ASHLRSSAHR RKAAPPPGGP PITVTNSATA VPAAVAFAKE EARLPHTDPN 
      2560 
PKTTTTSTLL AL
Length:2,562
Mass (Da):273,485
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71B4EA2972A84F81
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90426 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13V → I in BAD90426 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB190186 mRNA Translation: BAE78491.1
AC157212 Genomic DNA No translation available.
AK220366 mRNA Translation: BAD90426.1 Different initiation.
BC050052 mRNA Translation: AAH50052.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27107.1

NCBI Reference Sequences

More...RefSeqi		NP_001034287.1, NM_001039198.1
XP_006519044.1, XM_006518981.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000036328; ENSMUSP00000045156; ENSMUSG00000040721

Database of genes from NCBI RefSeq genomes

More...GeneIDi		239102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:239102

UCSC genome browser

More...UCSCi		uc007txz.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190186 mRNA Translation: BAE78491.1
AC157212 Genomic DNA No translation available.
AK220366 mRNA Translation: BAD90426.1 Different initiation.
BC050052 mRNA Translation: AAH50052.1
CCDSiCCDS27107.1
RefSeqiNP_001034287.1, NM_001039198.1
XP_006519044.1, XM_006518981.3

3D structure databases

SMRiQ2MHN3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045156

PTM databases

iPTMnetiQ2MHN3
PhosphoSitePlusiQ2MHN3

Proteomic databases

MaxQBiQ2MHN3
PaxDbiQ2MHN3
PeptideAtlasiQ2MHN3
PRIDEiQ2MHN3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51729, 41 antibodies

Genome annotation databases

EnsembliENSMUST00000036328; ENSMUSP00000045156; ENSMUSG00000040721
GeneIDi239102
KEGGimmu:239102
UCSCiuc007txz.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85446
MGIiMGI:2686934, Zfhx2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
GeneTreeiENSGT00940000160537
HOGENOMiCLU_001401_1_0_1
InParanoidiQ2MHN3
OMAiTVFCCPY
OrthoDBi15351at2759
PhylomeDBiQ2MHN3
TreeFamiTF323288

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		239102, 2 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Zfhx2, mouse

Protein Ontology

More...PROi		PR:Q2MHN3
RNActiQ2MHN3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040721, Expressed in cerebellar cortex and 133 other tissues

Family and domain databases

CDDicd00086, homeodomain, 3 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR027028, ZFHX2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR45891:SF1, PTHR45891:SF1, 1 hit
PfamiView protein in Pfam
PF00046, Homeodomain, 3 hits
SMARTiView protein in SMART
SM00389, HOX, 3 hits
SM00355, ZnF_C2H2, 15 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 3 hits
SSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFHX2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2MHN3
Secondary accession number(s): Q5DU04, Q80VJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: February 21, 2006
Last modified: December 2, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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