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Protein

Ferritin light chain

Gene

FTL

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronPROSITE-ProRule annotation1
Metal bindingi57IronPROSITE-ProRule annotation1
Metal bindingi58IronPROSITE-ProRule annotation1
Metal bindingi61IronPROSITE-ProRule annotation1
Metal bindingi64IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin light chain
Short name:
Ferritin L subunit
Gene namesi
Name:FTL
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome E2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002267222 – 175Ferritin light chainAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ2MHN1

Expressioni

Gene expression databases

BgeeiENSFCAG00000003348 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2MHN1
SMRiQ2MHN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiENOG410KDTW Eukaryota
ENOG4111Q1M LUCA
GeneTreeiENSGT00760000119129
HOVERGENiHBG000410
InParanoidiQ2MHN1
KOiK13625
OMAiVNLYLRA
OrthoDBiEOG091G0J20

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2MHN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQIRQNYS TEVEAAVNRL VNMHLRASYT YLSLGFYFDR DDVALEGVGH
60 70 80 90 100
FFRELAEEKR EGAERLLKMQ NQRGGRALFL DVQKPSQDEW GKTLDAMEAA
110 120 130 140 150
LLLEKNLNQG LLDLHALGSA RADPHLCDFL ENHFLDEEVK LIKKMGDHLT
160 170
NLRRLSGPQA ELGEYLFERL TLKHD
Length:175
Mass (Da):20,103
Last modified:January 23, 2007 - v3
Checksum:iA7FE5B7AB90EC122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193258 mRNA Translation: BAE78406.1
RefSeqiNP_001041615.1, NM_001048150.1

Genome annotation databases

EnsembliENSFCAT00000003348; ENSFCAP00000003087; ENSFCAG00000003348
GeneIDi654515
KEGGifca:654515

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193258 mRNA Translation: BAE78406.1
RefSeqiNP_001041615.1, NM_001048150.1

3D structure databases

ProteinModelPortaliQ2MHN1
SMRiQ2MHN1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2MHN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000003348; ENSFCAP00000003087; ENSFCAG00000003348
GeneIDi654515
KEGGifca:654515

Organism-specific databases

CTDi2512

Phylogenomic databases

eggNOGiENOG410KDTW Eukaryota
ENOG4111Q1M LUCA
GeneTreeiENSGT00760000119129
HOVERGENiHBG000410
InParanoidiQ2MHN1
KOiK13625
OMAiVNLYLRA
OrthoDBiEOG091G0J20

Gene expression databases

BgeeiENSFCAG00000003348 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRIL_FELCA
AccessioniPrimary (citable) accession number: Q2MHN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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