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Protein

Serine/threonine-protein kinase HT1

Gene

HT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine kinase involved in the control of stomatal movement in response to CO2. Shows a reduced response to ABA or light compared to CO2.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113ATPCurated1
Active sitei212Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi92 – 100ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase HT1 (EC:2.7.11.1)
Alternative name(s):
High leaf temperature protein 1
Gene namesi
Name:HT1
Ordered Locus Names:At1g62400
ORF Names:F24O1.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G62400

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi113K → W: Induces a disrupted CO(2) response. 1 Publication1
Mutagenesisi211R → K in ht1-1; impairs the ability to control stomatal movements in response to CO(2) probably due to loss of protein kinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352381 – 390Serine/threonine-protein kinase HT1Add BLAST390

Proteomic databases

PaxDbiQ2MHE4

Expressioni

Tissue specificityi

Mainly localizes in guard cells. Expressed at low level in leaves, stems, roots and flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ2MHE4 baseline and differential
GenevisibleiQ2MHE4 AT

Interactioni

Subunit structurei

Interacts with DTX56.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRK2EQ940H62EBI-11174828,EBI-782514

Protein-protein interaction databases

IntActiQ2MHE4, 2 interactors
STRINGi3702.AT1G62400.1

Structurei

3D structure databases

ProteinModelPortaliQ2MHE4
SMRiQ2MHE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 359Protein kinasePROSITE-ProRule annotationAdd BLAST274

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233857
InParanoidiQ2MHE4
OrthoDBiEOG09360D1R
PhylomeDBiQ2MHE4

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR015783 Ser/Thr_kinase_HT1_plant
PANTHERiPTHR23257:SF619 PTHR23257:SF619, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q2MHE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLCFNPFR LRWSLRSKLP LEPSLPNLPC NPSSSKTNRY AEAETMEKKR
60 70 80 90 100
FDSMESWSMI LESENVETWE ASKGEREEWT ADLSQLFIGN KFASGAHSRI
110 120 130 140 150
YRGIYKQRAV AVKMVRIPTH KEETRAKLEQ QFKSEVALLS RLFHPNIVQF
160 170 180 190 200
IAACKKPPVY CIITEYMSQG NLRMYLNKKE PYSLSIETVL RLALDISRGM
210 220 230 240 250
EYLHSQGVIH RDLKSNNLLL NDEMRVKVAD FGTSCLETQC REAKGNMGTY
260 270 280 290 300
RWMAPEMIKE KPYTRKVDVY SFGIVLWELT TALLPFQGMT PVQAAFAVAE
310 320 330 340 350
KNERPPLPAS CQPALAHLIK RCWSENPSKR PDFSNIVAVL EKYDECVKEG
360 370 380 390
LPLTSHASLT KTKKAILDHL KGCVTSISSP FSSSSVPVNA
Length:390
Mass (Da):44,281
Last modified:February 21, 2006 - v1
Checksum:i8198FDAC936DC573
GO

Sequence cautioni

The sequence AAF70839 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB221045 Genomic DNA Translation: BAE75921.1
AC003113 Genomic DNA Translation: AAF70839.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33962.2
PIRiT01451
RefSeqiNP_176430.2, NM_104920.3
UniGeneiAt.28069

Genome annotation databases

EnsemblPlantsiAT1G62400.1; AT1G62400.1; AT1G62400
GeneIDi842538
GrameneiAT1G62400.1; AT1G62400.1; AT1G62400
KEGGiath:AT1G62400

Similar proteinsi

Entry informationi

Entry nameiHT1_ARATH
AccessioniPrimary (citable) accession number: Q2MHE4
Secondary accession number(s): F4HYS2, Q9MAV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 21, 2006
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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