UniProtKB - Q2MH31 (SMRP1_MOUSE)
Protein
Spermatid-specific manchette-related protein 1
Gene
Smrp1
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in differentiation or function of ciliated cells (By similarity). May play a role in spermatogenesis.By similarity1 Publication
GO - Molecular functioni
- alpha-tubulin binding Source: MGI
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- cellular protein-containing complex assembly Source: MGI
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Spermatid-specific manchette-related protein 1Alternative name(s): Ciliated bronchial epithelial protein 1 |
Gene namesi | Name:Smrp1 Synonyms:Cbe1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920971 1110017D15Rik |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- Cytoplasm By similarity
Note: Localizes to the manchette in elongating spermatids. Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines.
Cytoskeleton
- manchette Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- perinuclear region of cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296260 | 1 – 260 | Spermatid-specific manchette-related protein 1Add BLAST | 260 |
Proteomic databases
PaxDbi | Q2MH31 |
PRIDEi | Q2MH31 |
TopDownProteomicsi | Q2MH31-1 [Q2MH31-1] |
PTM databases
iPTMneti | Q2MH31 |
PhosphoSitePlusi | Q2MH31 |
Expressioni
Tissue specificityi
Isoforms 1 is testis-specific where it is expressed exclusively in germ cells (at protein level). Isoform 2 is testis-specific. Isoform 3 and isoform 4 are expressed in both lung and testis.2 Publications
Developmental stagei
During male germ cell development, expression of isoform 1 begins at day 21, increases after day 30 and continues to increase in the adult. Expressed in elongating spermatids from steps 9-12 (at protein level). Expression in the lung increases at 16 dpc.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000028441 Expressed in 106 organ(s), highest expression level in testis |
ExpressionAtlasi | Q2MH31 baseline and differential |
Genevisiblei | Q2MH31 MM |
Interactioni
Subunit structurei
Interacts with alpha-tubulin.
1 PublicationGO - Molecular functioni
- alpha-tubulin binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030152 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SMRP1 family.Curated
Phylogenomic databases
eggNOGi | ENOG410IJMT Eukaryota ENOG41119UP LUCA |
GeneTreei | ENSGT00390000000945 |
HOGENOMi | HOG000111634 |
InParanoidi | Q2MH31 |
KOi | K18634 |
OMAi | GHPYFPE |
OrthoDBi | 942401at2759 |
PhylomeDBi | Q2MH31 |
TreeFami | TF335656 |
Family and domain databases
InterProi | View protein in InterPro IPR028195 SMRP1 |
PANTHERi | PTHR35664 PTHR35664, 1 hit |
Pfami | View protein in Pfam PF15181 SMRP1, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2MH31-1) [UniParc]FASTAAdd to basket
Also known as: Cbe1-long-ORF1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLWAWEAN KFVTPGLTQT
60 70 80 90 100
MHRHVDPEAL QKMTKCAAQD YTYKSSISGH PYLPEKYWLS PDEEDKCCPS
110 120 130 140 150
YLDNDRYNTW KTSPCSNYWN KYTGCLPRLS KDTGMESVRG MPLEYPPKQE
160 170 180 190 200
RLNAYEREVV VNMLNSLSRN RTLPQIVPRC GCVDPLPGRL PYQGYESPCS
210 220 230 240 250
GRHYCLRGMD YCTTREPSTE RRLRPLCSQQ PTECVALRSP ARNAMCCYNS
260
PAIILPVSQP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ANN9 | A2ANN9_MOUSE | MCG9747, isoform CRA_b | 1110017D15Rik mCG_9747 | 202 | Annotation score: | ||
F7CUE2 | F7CUE2_MOUSE | RIKEN cDNA 1110017D15 gene | 1110017D15Rik | 215 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027172 | 1 – 134 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 134 | |
Alternative sequenceiVSP_027173 | 233 – 260 | ECVAL…PVSQP → VRSVSPFGHRPGMQCAVTTP PPSFYPYPNLRWDTSHFKKT GGSQRNNYVVHPEFVSETCP VYPS in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB231294 mRNA Translation: BAE78528.1 DQ873295 mRNA Translation: ABI35956.1 DQ873296 mRNA Translation: ABI35957.1 AK003742 mRNA Translation: BAB22974.1 AL831723 Genomic DNA No translation available. |
CCDSi | CCDS38717.1 [Q2MH31-1] |
RefSeqi | NP_001041470.1, NM_001048005.1 [Q2MH31-1] NP_001240706.1, NM_001253777.1 [Q2MH31-4] NP_001240707.1, NM_001253778.1 [Q2MH31-3] NP_082900.1, NM_028624.1 [Q2MH31-2] |
Genome annotation databases
Ensembli | ENSMUST00000030152; ENSMUSP00000030152; ENSMUSG00000028441 [Q2MH31-1] |
GeneIDi | 73721 |
KEGGi | mmu:73721 |
UCSCi | uc008siu.1 mouse [Q2MH31-2] uc008siv.1 mouse [Q2MH31-3] uc008six.1 mouse [Q2MH31-1] uc008siy.1 mouse [Q2MH31-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB231294 mRNA Translation: BAE78528.1 DQ873295 mRNA Translation: ABI35956.1 DQ873296 mRNA Translation: ABI35957.1 AK003742 mRNA Translation: BAB22974.1 AL831723 Genomic DNA No translation available. |
CCDSi | CCDS38717.1 [Q2MH31-1] |
RefSeqi | NP_001041470.1, NM_001048005.1 [Q2MH31-1] NP_001240706.1, NM_001253777.1 [Q2MH31-4] NP_001240707.1, NM_001253778.1 [Q2MH31-3] NP_082900.1, NM_028624.1 [Q2MH31-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030152 |
PTM databases
iPTMneti | Q2MH31 |
PhosphoSitePlusi | Q2MH31 |
Proteomic databases
PaxDbi | Q2MH31 |
PRIDEi | Q2MH31 |
TopDownProteomicsi | Q2MH31-1 [Q2MH31-1] |
Genome annotation databases
Ensembli | ENSMUST00000030152; ENSMUSP00000030152; ENSMUSG00000028441 [Q2MH31-1] |
GeneIDi | 73721 |
KEGGi | mmu:73721 |
UCSCi | uc008siu.1 mouse [Q2MH31-2] uc008siv.1 mouse [Q2MH31-3] uc008six.1 mouse [Q2MH31-1] uc008siy.1 mouse [Q2MH31-4] |
Organism-specific databases
MGIi | MGI:1920971 1110017D15Rik |
Phylogenomic databases
eggNOGi | ENOG410IJMT Eukaryota ENOG41119UP LUCA |
GeneTreei | ENSGT00390000000945 |
HOGENOMi | HOG000111634 |
InParanoidi | Q2MH31 |
KOi | K18634 |
OMAi | GHPYFPE |
OrthoDBi | 942401at2759 |
PhylomeDBi | Q2MH31 |
TreeFami | TF335656 |
Miscellaneous databases
PROi | PR:Q2MH31 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028441 Expressed in 106 organ(s), highest expression level in testis |
ExpressionAtlasi | Q2MH31 baseline and differential |
Genevisiblei | Q2MH31 MM |
Family and domain databases
InterProi | View protein in InterPro IPR028195 SMRP1 |
PANTHERi | PTHR35664 PTHR35664, 1 hit |
Pfami | View protein in Pfam PF15181 SMRP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMRP1_MOUSE | |
Accessioni | Q2MH31Primary (citable) accession number: Q2MH31 Secondary accession number(s): Q0GC36, Q9D1B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | February 21, 2006 | |
Last modified: | October 16, 2019 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot