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Protein

DNA replication helicase

Gene

UL5

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotationImported, Hydrolase
Biological processDNA replicationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication helicaseUniRule annotation (EC:3.6.4.-UniRule annotation)
Gene namesi
Name:UL5Imported
Synonyms:HELIUniRule annotation
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotation

Interactioni

Subunit structurei

Associates with the primase and the primase-associated factor to form the helicase-primase complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae helicase family.UniRule annotation

Family and domain databases

HAMAPiMF_04030 HSV_HELI, 1 hit
InterProiView protein in InterPro
IPR003840 DNA_helicase
IPR034711 HSV_HELI
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02689 Herpes_Helicase, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q2MGV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGGERQL DGQKPGPPHL QQPGDRPAVP GRAEAFLNFT SMHGVQPILK
60 70 80 90 100
RIRELSQQQL DGAQVPRLQW FRDVAALESP AGLPLREFPF AVYLITGNAG
110 120 130 140 150
SGKSTCVQTI NEVLDCVVTG ATRIAAQNMY AKLSGAFLSR PINTIFHEFG
160 170 180 190 200
FRGNHVQAQL GQYPYTLTSN PASLEDLQRR DLTYYWEVIL DLTKRALAAS
210 220 230 240 250
GGEESRNEFR ALAALERTLG LAEGALTRLA PATHGALPAF TRSNVIVIDE
260 270 280 290 300
AGLLGRHLLT AVVYCWWMIN ALYHTPQYAA RLRPVLVCVG SPTQTASLES
310 320 330 340 350
TFEHQKLRCS VRQSENVLTY LICNRTLREY ARLSYSWAIF INNKRCVEHE
360 370 380 390 400
FGNLMKVLEY GLPITEEHMQ FVDRFVVPES YITNPANLPG WTRLFSSHKE
410 420 430 440 450
VSAYMAKLHA YLKVTREGEF VVFTLPVLTF VSVKEFDEYR RLTHQPGLTI
460 470 480 490 500
EKWLTANASR ITNYSQSQDQ DAGHMRCEVH SKQQLVVARN DVTYVLNSQI
510 520 530 540 550
AVTARLRKLV FGFSGTFRAF EAVLRDDSFV KTQGETSVEF AYRFLSRLIF
560 570 580 590 600
SGLISFYNFL QRPGLDATQR TLAYARMGEL TAEILSLRPK SSGAPTQASV
610 620 630 640 650
IADAGAPGER AFDFKQLGPR DGGPDDFPDD DLDVIFAGLD EQQLDVFYCH
660 670 680 690 700
YTPGEPETTA AVHTQFALLK RAFLGRFRIL QELFGEAFEG APFSTYVDNV
710 720 730 740 750
IFRGCEMLTG SPRGGLMSVA LQTDNYTLMG YTYARVFAFA DELRRRHATA
760 770 780 790 800
NVAELLEEAP LPYVVLRDQH GFMSVVNTNI SEFVESIDST ELAMAINADY
810 820 830 840 850
GISSKLAMTI TRSQGLSLDK VAICFTPGNL RLNSAYVAMS RTTSSEFLRM
860 870 880
NLNPLRERHE RDDVISEHIL SALRDPNVVI VY
Length:882
Mass (Da):98,593
Last modified:February 21, 2006 - v1
Checksum:i6FF297E520929A7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM585512 Genomic DNA Translation: ADM23543.1
HM585513 Genomic DNA Translation: ADM23618.1
AB247571 Genomic DNA Translation: BAE78513.1
AB247572 Genomic DNA Translation: BAE78514.1
LT594110 Genomic DNA Translation: SBS69280.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM585512 Genomic DNA Translation: ADM23543.1
HM585513 Genomic DNA Translation: ADM23618.1
AB247571 Genomic DNA Translation: BAE78513.1
AB247572 Genomic DNA Translation: BAE78514.1
LT594110 Genomic DNA Translation: SBS69280.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04030 HSV_HELI, 1 hit
InterProiView protein in InterPro
IPR003840 DNA_helicase
IPR034711 HSV_HELI
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02689 Herpes_Helicase, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ2MGV2_HHV1
AccessioniPrimary (citable) accession number: Q2MGV2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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