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Protein

Major DNA-binding protein

Gene

UL29

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri499 – 512UniRule annotationAdd BLAST14

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationImported
Biological processDNA replicationUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Major DNA-binding proteinUniRule annotation
Gene namesi
Name:UL29Imported
Synonyms:DBPUniRule annotation
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000126435 Componenti: Genome
  • UP000166330 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation
  • Note: In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotation

Interactioni

Subunit structurei

Homooligomers. Forms double-helical filaments necessary for the formation of replication compartments within the host nucleus. Interacts with the origin-binding protein. Interacts with the helicase primase complex; this interaction stimulates primer synthesis activity of the helicase-primase complex. Interacts with the DNA polymerase. Interacts with the alkaline exonuclease; this interaction increases its nuclease processivity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1171 – 1196Required for nuclear localizationUniRule annotationAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi843 – 844Required for filament formationUniRule annotation2
Motifi1142 – 1144Required for filament formationUniRule annotation3

Sequence similaritiesi

Belongs to the herpesviridae major DNA-binding protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri499 – 512UniRule annotationAdd BLAST14

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_04007 HSV_DNBI, 1 hit
InterProiView protein in InterPro
IPR035989 DBP_sf
IPR000635 Viral_ssDNA-bd
PfamiView protein in Pfam
PF00747 Viral_DNA_bp, 1 hit
SUPFAMiSSF118208 SSF118208, 1 hit

Sequencei

Sequence statusi: Complete.

Q2MGU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKPKTATT IKVPPGPLGY VYARACPSEG IELLALLSAR SGDADVAVAP
60 70 80 90 100
LVVGLTVESG FEANVAVVVG SRTTGLGGTA VSLKLTPSHY SSSVYVFHGG
110 120 130 140 150
RHLDPSTQAP NLTRLCERAR RHFGFSDYTP RPGDLKHETT GEALCERLGL
160 170 180 190 200
DPDRALLYLV VTEGFKEAVC INNTFLHLGG SDKVTIGGAE VHRIPVYPLQ
210 220 230 240 250
LFMPDFSRVI AEPFNANHRS IGENFTYPLP FFNRPLNRLL FEAVVGPAAV
260 270 280 290 300
ALRCRNVDAV ARAAAHLAFD ENHEGAALPA DITFTAFEAS QGKTPRGGRD
310 320 330 340 350
GGGKGPAGGF EQRLASVMAG DAALALESIV SMAVFDEPPT DISAWPLCEG
360 370 380 390 400
QDTAAARANA VGAYLARAAG LVGAMVFSTN SALHLTEVDD AGPADPKDHS
410 420 430 440 450
KPSFYRFFLV PGTHVAANPQ VDREGHVVPG FEGRPTAPLV GGTQEFAGEH
460 470 480 490 500
LAMLCGFSPA LLAKMLFYLE RCDGGVIVGR QEMDVFRYVA DSNQTDVPCN
510 520 530 540 550
LCTFDTRHAC VHTTLMRLRA RHPKFASAAR GAIGVFGTMN SMYSDCDVLG
560 570 580 590 600
NYAAFSALKR ADGSETARTI MQETYRAATE RVMAELETLQ YVDQAVPTAM
610 620 630 640 650
GRLETIITNR EALHTVVNNV RQVVDREVEQ LMRNLVEGRN FKFRDGLGEA
660 670 680 690 700
NHAMSLTLDP YACGPCPLLQ LLGRRSNLAV YQDLALSQCH GVFAGQSVEG
710 720 730 740 750
RNFRNQFQPV LRRRVMDMFN NGFLSAKTLT VALSEGAAIC APSLTAGQTA
760 770 780 790 800
PAESSFEGDV ARVTLGFPKE LRVKSRVLFA GASANASEAA KARVASLQSA
810 820 830 840 850
YQKPDKRVDI LLGPLGFLLK QFHAAIFPNG KPPGSNQPNP QWFWTALQRN
860 870 880 890 900
QLPARLLSRE DIETIAFIKK FSLDYGAINF INLAPNNVSE LAMYYMANQI
910 920 930 940 950
LRYCDHSTYF INTLTAIIAG SRRPPSVQAA AAWSAQGGAG LEAGARALMD
960 970 980 990 1000
AVDAHPGAWT SMFASCNLLR PVMAARPMVV LGLSISKYYG MAGNDRVFQA
1010 1020 1030 1040 1050
GNWASLMGGK NACPLLIFDR TRKFVLACPR AGFVCAASSL GGGAHESSLC
1060 1070 1080 1090 1100
EQLRGIISEG GAAVASSVFV ATVKSLGPRT QQLQIEDWLA LLEDEYLSEE
1110 1120 1130 1140 1150
MMELTARALE RGNGEWSTDA ALEVAHEAEA LVSQLGNAGE VFNFGDFGCE
1160 1170 1180 1190
DDNATPFGGP GAPGPAFAGR KRAFHGDDPF GEGPPDKKGD LTLDML
Length:1,196
Mass (Da):128,288
Last modified:February 21, 2006 - v1
Checksum:i3A0EE0B53108894B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU734772 Genomic DNA Translation: ADD60076.1
HM585512 Genomic DNA Translation: ADM23568.1
HM585513 Genomic DNA Translation: ADM23643.1
HM585515 Genomic DNA Translation: ADM23794.1
JN400093 Genomic DNA Translation: AER37613.1
JN420338 Genomic DNA Translation: AER37753.1
JN420341 Genomic DNA Translation: AER37967.1
KJ847330 Genomic DNA Translation: AKE48608.1
KR011274 Genomic DNA Translation: AKG59212.1
KR011279 Genomic DNA Translation: AKG59576.1
KR011280 Genomic DNA Translation: AKG59648.1
KR011281 Genomic DNA Translation: AKG59721.1
KR011283 Genomic DNA Translation: AKG59864.1
KR011285 Genomic DNA Translation: AKG60012.1
KR011288 Genomic DNA Translation: AKG60228.1
KR011291 Genomic DNA Translation: AKG60441.1
KR011292 Genomic DNA Translation: AKG60513.1
KR011295 Genomic DNA Translation: AKG60730.1
KR011296 Genomic DNA Translation: AKG60802.1
KR011297 Genomic DNA Translation: AKG60872.1
KR011301 Genomic DNA Translation: AKG61160.1
KR011302 Genomic DNA Translation: AKG61233.1
KR011303 Genomic DNA Translation: AKG61306.1
KR011304 Genomic DNA Translation: AKG61377.1
KR011305 Genomic DNA Translation: AKG61449.1
KR011306 Genomic DNA Translation: AKG61522.1
KR011307 Genomic DNA Translation: AKG61596.1
KR011308 Genomic DNA Translation: AKG61669.1
KR011310 Genomic DNA Translation: AKG61813.1
KR011311 Genomic DNA Translation: AKG61887.1
KR011312 Genomic DNA Translation: AKG61959.1
KR052507 Genomic DNA Translation: AKH80429.1
KT425108 Genomic DNA Translation: ALM22672.1
KX265027 Genomic DNA Translation: ANN84311.1
KX265028 Genomic DNA Translation: ANN84388.1
KX265029 Genomic DNA Translation: ANN84463.1
KX265031 Genomic DNA Translation: ANN84617.1
KX265032 Genomic DNA Translation: ANN84693.1
KX265034 Genomic DNA Translation: ANN84846.1
KX265035 Genomic DNA Translation: ANN84923.1
KX265037 Genomic DNA Translation: ANN85076.1
KX265038 Genomic DNA Translation: ANN85152.1
KX265039 Genomic DNA Translation: ANN85227.1
KX265042 Genomic DNA Translation: ANN85457.1
KX265044 Genomic DNA Translation: ANN85611.1
KX265046 Genomic DNA Translation: ANN85764.1
KX946970 Genomic DNA Translation: AOY36648.1
KX424525 Genomic DNA Translation: ARB08920.1
MH160360 Genomic DNA Translation: AWO69232.1
MH160363 Genomic DNA Translation: AWO69531.1
MH160371 Genomic DNA Translation: AWO70283.1
MH160372 Genomic DNA Translation: AWO70374.1
MH160376 Genomic DNA Translation: AWO70752.1
MH160383 Genomic DNA Translation: AWO71393.1
MH160386 Genomic DNA Translation: AWO71674.1
MH160389 Genomic DNA Translation: AWO71944.1
MH160390 Genomic DNA Translation: AWO72040.1
MG999839 Genomic DNA Translation: AWW07878.1
MG999842 Genomic DNA Translation: AWW08208.1
MG999843 Genomic DNA Translation: AWW08299.1
MG999844 Genomic DNA Translation: AWW08389.1
MG999846 Genomic DNA Translation: AWW08592.1
MG999848 Genomic DNA Translation: AWW08779.1
MG999850 Genomic DNA Translation: AWW08950.1
MG999852 Genomic DNA Translation: AWW09117.1
MG999853 Genomic DNA Translation: AWW09199.1
MG999854 Genomic DNA Translation: AWW09283.1
MG999865 Genomic DNA Translation: AWW10302.1
MG999867 Genomic DNA Translation: AWW10491.1
MG999871 Genomic DNA Translation: AWW10824.1
MG999877 Genomic DNA Translation: AWW11415.1
MG999880 Genomic DNA Translation: AWW11690.1
MG999882 Genomic DNA Translation: AWW11870.1
MG999883 Genomic DNA Translation: AWW11967.1
MG999884 Genomic DNA Translation: AWW12055.1
MG999887 Genomic DNA Translation: AWW12304.1
MG999888 Genomic DNA Translation: AWW12388.1
MG999890 Genomic DNA Translation: AWW12557.1
MG999892 Genomic DNA Translation: AWW12752.1
MG999893 Genomic DNA Translation: AWW12844.1
MG999894 Genomic DNA Translation: AWW12939.1
MG708284 Genomic DNA Translation: AWX34665.1
MG708285 Genomic DNA Translation: AWX34734.1
MG708286 Genomic DNA Translation: AWX34805.1
MG708287 Genomic DNA Translation: AWX34873.1
MG708289 Genomic DNA Translation: AWX35015.1
MG708290 Genomic DNA Translation: AWX35084.1
MG708291 Genomic DNA Translation: AWX35156.1
MG708292 Genomic DNA Translation: AWX35226.1
MH102298 Genomic DNA Translation: AWY10603.1
AB247574 Genomic DNA Translation: BAE78516.1
AB247575 Genomic DNA Translation: BAE78517.1
AB247576 Genomic DNA Translation: BAE78518.1
AB247578 Genomic DNA Translation: BAE78520.1
LT594108 Genomic DNA Translation: SBS69436.1
LT594110 Genomic DNA Translation: SBS69512.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU734772 Genomic DNA Translation: ADD60076.1
HM585512 Genomic DNA Translation: ADM23568.1
HM585513 Genomic DNA Translation: ADM23643.1
HM585515 Genomic DNA Translation: ADM23794.1
JN400093 Genomic DNA Translation: AER37613.1
JN420338 Genomic DNA Translation: AER37753.1
JN420341 Genomic DNA Translation: AER37967.1
KJ847330 Genomic DNA Translation: AKE48608.1
KR011274 Genomic DNA Translation: AKG59212.1
KR011279 Genomic DNA Translation: AKG59576.1
KR011280 Genomic DNA Translation: AKG59648.1
KR011281 Genomic DNA Translation: AKG59721.1
KR011283 Genomic DNA Translation: AKG59864.1
KR011285 Genomic DNA Translation: AKG60012.1
KR011288 Genomic DNA Translation: AKG60228.1
KR011291 Genomic DNA Translation: AKG60441.1
KR011292 Genomic DNA Translation: AKG60513.1
KR011295 Genomic DNA Translation: AKG60730.1
KR011296 Genomic DNA Translation: AKG60802.1
KR011297 Genomic DNA Translation: AKG60872.1
KR011301 Genomic DNA Translation: AKG61160.1
KR011302 Genomic DNA Translation: AKG61233.1
KR011303 Genomic DNA Translation: AKG61306.1
KR011304 Genomic DNA Translation: AKG61377.1
KR011305 Genomic DNA Translation: AKG61449.1
KR011306 Genomic DNA Translation: AKG61522.1
KR011307 Genomic DNA Translation: AKG61596.1
KR011308 Genomic DNA Translation: AKG61669.1
KR011310 Genomic DNA Translation: AKG61813.1
KR011311 Genomic DNA Translation: AKG61887.1
KR011312 Genomic DNA Translation: AKG61959.1
KR052507 Genomic DNA Translation: AKH80429.1
KT425108 Genomic DNA Translation: ALM22672.1
KX265027 Genomic DNA Translation: ANN84311.1
KX265028 Genomic DNA Translation: ANN84388.1
KX265029 Genomic DNA Translation: ANN84463.1
KX265031 Genomic DNA Translation: ANN84617.1
KX265032 Genomic DNA Translation: ANN84693.1
KX265034 Genomic DNA Translation: ANN84846.1
KX265035 Genomic DNA Translation: ANN84923.1
KX265037 Genomic DNA Translation: ANN85076.1
KX265038 Genomic DNA Translation: ANN85152.1
KX265039 Genomic DNA Translation: ANN85227.1
KX265042 Genomic DNA Translation: ANN85457.1
KX265044 Genomic DNA Translation: ANN85611.1
KX265046 Genomic DNA Translation: ANN85764.1
KX946970 Genomic DNA Translation: AOY36648.1
KX424525 Genomic DNA Translation: ARB08920.1
MH160360 Genomic DNA Translation: AWO69232.1
MH160363 Genomic DNA Translation: AWO69531.1
MH160371 Genomic DNA Translation: AWO70283.1
MH160372 Genomic DNA Translation: AWO70374.1
MH160376 Genomic DNA Translation: AWO70752.1
MH160383 Genomic DNA Translation: AWO71393.1
MH160386 Genomic DNA Translation: AWO71674.1
MH160389 Genomic DNA Translation: AWO71944.1
MH160390 Genomic DNA Translation: AWO72040.1
MG999839 Genomic DNA Translation: AWW07878.1
MG999842 Genomic DNA Translation: AWW08208.1
MG999843 Genomic DNA Translation: AWW08299.1
MG999844 Genomic DNA Translation: AWW08389.1
MG999846 Genomic DNA Translation: AWW08592.1
MG999848 Genomic DNA Translation: AWW08779.1
MG999850 Genomic DNA Translation: AWW08950.1
MG999852 Genomic DNA Translation: AWW09117.1
MG999853 Genomic DNA Translation: AWW09199.1
MG999854 Genomic DNA Translation: AWW09283.1
MG999865 Genomic DNA Translation: AWW10302.1
MG999867 Genomic DNA Translation: AWW10491.1
MG999871 Genomic DNA Translation: AWW10824.1
MG999877 Genomic DNA Translation: AWW11415.1
MG999880 Genomic DNA Translation: AWW11690.1
MG999882 Genomic DNA Translation: AWW11870.1
MG999883 Genomic DNA Translation: AWW11967.1
MG999884 Genomic DNA Translation: AWW12055.1
MG999887 Genomic DNA Translation: AWW12304.1
MG999888 Genomic DNA Translation: AWW12388.1
MG999890 Genomic DNA Translation: AWW12557.1
MG999892 Genomic DNA Translation: AWW12752.1
MG999893 Genomic DNA Translation: AWW12844.1
MG999894 Genomic DNA Translation: AWW12939.1
MG708284 Genomic DNA Translation: AWX34665.1
MG708285 Genomic DNA Translation: AWX34734.1
MG708286 Genomic DNA Translation: AWX34805.1
MG708287 Genomic DNA Translation: AWX34873.1
MG708289 Genomic DNA Translation: AWX35015.1
MG708290 Genomic DNA Translation: AWX35084.1
MG708291 Genomic DNA Translation: AWX35156.1
MG708292 Genomic DNA Translation: AWX35226.1
MH102298 Genomic DNA Translation: AWY10603.1
AB247574 Genomic DNA Translation: BAE78516.1
AB247575 Genomic DNA Translation: BAE78517.1
AB247576 Genomic DNA Translation: BAE78518.1
AB247578 Genomic DNA Translation: BAE78520.1
LT594108 Genomic DNA Translation: SBS69436.1
LT594110 Genomic DNA Translation: SBS69512.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04007 HSV_DNBI, 1 hit
InterProiView protein in InterPro
IPR035989 DBP_sf
IPR000635 Viral_ssDNA-bd
PfamiView protein in Pfam
PF00747 Viral_DNA_bp, 1 hit
SUPFAMiSSF118208 SSF118208, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ2MGU6_HHV1
AccessioniPrimary (citable) accession number: Q2MGU6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 10, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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