We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q2MFP1 (DOIS_STRRY)
Protein
2-deoxy-scyllo-inosose synthase
Gene
parC
Organism
Streptomyces rimosus subsp. paromomycinus
Status
Functioni
Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI).
By similarityCatalytic activityi
- EC:4.2.3.124
Cofactori
Protein has several cofactor binding sites:: 2-deoxystreptamine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 2-deoxystreptamine from D-glucose 6-phosphate. This subpathway is part of the pathway 2-deoxystreptamine biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-deoxystreptamine from D-glucose 6-phosphate, the pathway 2-deoxystreptamine biosynthesis and in Metabolic intermediate biosynthesis.
Pathwayi: paromomycin biosynthesis
This protein is involved in the pathway paromomycin biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway paromomycin biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 42 | NADBy similarity | 1 | |
Active sitei | 142 | By similarity | 1 | |
Metal bindingi | 184 | CobaltBy similarity | 1 | |
Active sitei | 244 | By similarity | 1 | |
Metal bindingi | 247 | CobaltBy similarity | 1 | |
Metal bindingi | 263 | CobaltBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 73 – 76 | NADBy similarity | 4 | |
Nucleotide bindingi | 105 – 109 | NADBy similarity | 5 | |
Nucleotide bindingi | 129 – 130 | NADBy similarity | 2 | |
Nucleotide bindingi | 140 – 142 | NADBy similarity | 3 | |
Nucleotide bindingi | 151 – 152 | NADBy similarity | 2 |
GO - Molecular functioni
- carbon-oxygen lyase activity, acting on phosphates Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- aromatic amino acid family biosynthetic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Biological process | Antibiotic biosynthesis |
Ligand | Cobalt, Metal-binding, NAD |
Enzyme and pathway databases
UniPathwayi | UPA00907;UER00921 UPA00970 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-deoxy-scyllo-inosose synthase (EC:4.2.3.124)Short name: DOI synthase Short name: DOIS |
Gene namesi | Name:parC |
Organismi | Streptomyces rimosus subsp. paromomycinus |
Taxonomic identifieri | 92743 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234040 | 1 – 386 | 2-deoxy-scyllo-inosose synthaseAdd BLAST | 386 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR030963, DHQ_synth_fam IPR030960, DHQS/DOIS |
Pfami | View protein in Pfam PF01761, DHQ_synthase, 1 hit |
PIRSFi | PIRSF001455, DHQ_synth, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2MFP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHVTAITMED TSFPYRLGTE CAEEIVARLG ERAASRYLVV CDTTVAALYG
60 70 80 90 100
RDLVARLEKD AGPAVLLTHP AGEVHKRIGT VGDLAEQALA AGADRRSVVV
110 120 130 140 150
ALGGGITGNI AGLLASLLFR GITLVHVPTT VVAMLDSVLS LKQAVNASFG
160 170 180 190 200
KNLVGTFYQP AEVLADTAML RTLPARELRS GMGEVVKNAL AIRPSMIERL
210 220 230 240 250
AAELRPDARY EDAAMRWIIE ESVAAKAQVT GADKHERRDG LVLEYGHTTG
260 270 280 290 300
HAIEHAARGE VAHGAGVAIG MIVAAEVSRL LGHASGDLVG LHRELVAKAG
310 320 330 340 350
LEGSVPALVD PADVKHWLTY DNKRGYMPCP PAATPMVLLS APGEVLRSGP
360 370 380
LPLVPVPLEL LGRAVDALAA PAGQSAGAER LSPAPA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ628955 Genomic DNA Translation: CAF32374.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ628955 Genomic DNA Translation: CAF32374.1 |
3D structure databases
SMRi | Q2MFP1 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00907;UER00921 UPA00970 |
Family and domain databases
InterProi | View protein in InterPro IPR030963, DHQ_synth_fam IPR030960, DHQS/DOIS |
Pfami | View protein in Pfam PF01761, DHQ_synthase, 1 hit |
PIRSFi | PIRSF001455, DHQ_synth, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DOIS_STRRY | |
Accessioni | Q2MFP1Primary (citable) accession number: Q2MFP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | February 21, 2006 | |
Last modified: | December 11, 2019 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families