RGS21

Functionⁱ

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functionⁱ

GTPase activator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of signal transduction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor

Molecular function

Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 21 Short name: RGS21
Gene namesⁱ	Name:RGS21
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000253148.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26839 RGS21
MIMⁱ	612407 gene
neXtProtⁱ	NX_Q2M5E4

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	431704
Open Targets More...OpenTargetsⁱ	ENSG00000253148
PharmGKBⁱ	PA134875582

Polymorphism and mutation databases

BioMutaⁱ	RGS21
DMDMⁱ	121941516

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271375	1 – 152	Regulator of G-protein signaling 21Add BLAST		152

Proteomic databases

PaxDbⁱ	Q2M5E4
PeptideAtlas More...PeptideAtlasⁱ	Q2M5E4
PRIDEⁱ	Q2M5E4
ProteomicsDBⁱ	61388

PTM databases

iPTMnetⁱ	Q2M5E4
PhosphoSitePlusⁱ	Q2M5E4

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExⁱ	HS_RGS21

CleanExⁱ

HS_RGS21

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052843

HPAⁱ

HPA052843

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000428343

STRINGⁱ

9606.ENSP00000428343

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2M5E4
SMRⁱ	Q2M5E4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 137	RGSPROSITE-ProRule annotationAdd BLAST		117

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q2M5E4
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	CCFYRSP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q2M5E4
TreeFamⁱ	TF315837

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q2M5E4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF 
        60         70         80         90        100
WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI 
       110        120        130        140        150
AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP 

FL

Length:152

Mass (Da):17,671

Last modified:February 21, 2006 - v1

Checksum:ⁱD9EF097E89CA9731

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY643711 mRNA Translation: AAT64913.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41448.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001034241.1, NM_001039152.3
UniGeneⁱ	Hs.558673

Genome annotation databases

Ensemblⁱ	ENST00000417209; ENSP00000428343; ENSG00000253148
GeneIDⁱ	431704
KEGGⁱ	hsa:431704
UCSC genome browser More...UCSCⁱ	uc001gsh.4 human

Protein	Similar proteins		Species	Score	Length
Q2M5E4	UPI00080A4A50		Cebus capucinus imitator		174
UPI000D2F6809		MACNE		173
RGS21 isoform 1		PANTR		152
Regulator of G protein signaling 21		PANPA		152
Regulator of G protein signaling 21		GORGO		152
+40

Protein	Similar proteins		Species	Score	Length
Q2M5E4	UPI00080A4A50		Cebus capucinus imitator		174
UPI000D2F6809		MACNE		173
UPI0001CE2A5E		RABIT		152
UPI00064291C1		MICMU		152
UPI000762981F		MARMA		152
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY643711 mRNA Translation: AAT64913.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41448.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001034241.1, NM_001039152.3
UniGeneⁱ	Hs.558673

3D structure databases

ProteinModelPortalⁱ	Q2M5E4
SMRⁱ	Q2M5E4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000428343

STRINGⁱ

9606.ENSP00000428343

PTM databases

iPTMnetⁱ	Q2M5E4
PhosphoSitePlusⁱ	Q2M5E4

Polymorphism and mutation databases

BioMutaⁱ	RGS21
DMDMⁱ	121941516

Proteomic databases

PaxDbⁱ	Q2M5E4
PeptideAtlas More...PeptideAtlasⁱ	Q2M5E4
PRIDEⁱ	Q2M5E4
ProteomicsDBⁱ	61388

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	431704
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000417209; ENSP00000428343; ENSG00000253148
GeneIDⁱ	431704
KEGGⁱ	hsa:431704
UCSC genome browser More...UCSCⁱ	uc001gsh.4 human

Organism-specific databases

CTDⁱ	431704
DisGeNET More...DisGeNETⁱ	431704
EuPathDBⁱ	HostDB:ENSG00000253148.1
GeneCardsⁱ	RGS21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26839 RGS21
Human Protein Atlas More...HPAⁱ	HPA052843
MIMⁱ	612407 gene
neXtProtⁱ	NX_Q2M5E4
Open Targets More...OpenTargetsⁱ	ENSG00000253148
PharmGKBⁱ	PA134875582
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q2M5E4
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	CCFYRSP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q2M5E4
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	RGS21 human
GenomeRNAiⁱ	431704
Protein Ontology More...PROⁱ	PR:Q2M5E4
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_RGS21

CleanExⁱ

HS_RGS21

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS21_HUMAN
Accessionⁱ	Q2M5E4Primary (citable) accession number: Q2M5E4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	February 21, 2006
	Last modified:	June 20, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - Q2M5E4 (RGS21_HUMAN)

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Regulator of G-protein signaling 21

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ