UniProtKB - Q2M5E4 (RGS21_HUMAN)
Protein
Regulator of G-protein signaling 21
Gene
RGS21
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of signal transduction Source: UniProtKB-KW
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q2M5E4 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 21Short name: RGS21 |
Gene namesi | Name:RGS21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26839, RGS21 |
MIMi | 612407, gene |
neXtProti | NX_Q2M5E4 |
VEuPathDBi | HostDB:ENSG00000253148.1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 431704 |
OpenTargetsi | ENSG00000253148 |
PharmGKBi | PA134875582 |
Miscellaneous databases
Pharosi | Q2M5E4, Tdark |
Genetic variation databases
BioMutai | RGS21 |
DMDMi | 121941516 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271375 | 1 – 152 | Regulator of G-protein signaling 21Add BLAST | 152 |
Proteomic databases
PaxDbi | Q2M5E4 |
PeptideAtlasi | Q2M5E4 |
PRIDEi | Q2M5E4 |
ProteomicsDBi | 61388 |
PTM databases
iPTMneti | Q2M5E4 |
PhosphoSitePlusi | Q2M5E4 |
Expressioni
Tissue specificityi
Expressed ubiquitously.1 Publication
Gene expression databases
Bgeei | ENSG00000253148, Expressed in subventricular zone (inner) (primate) and 2 other tissues |
Organism-specific databases
HPAi | ENSG00000253148, Not detected |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428343 |
Miscellaneous databases
RNActi | Q2M5E4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 137 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161004 |
HOGENOMi | CLU_059863_1_5_1 |
InParanoidi | Q2M5E4 |
OMAi | VKGRCCF |
OrthoDBi | 1246872at2759 |
PhylomeDBi | Q2M5E4 |
TreeFami | TF315837 |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2M5E4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF
60 70 80 90 100
WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI
110 120 130 140 150
AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP
FL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY643711 mRNA Translation: AAT64913.1 |
CCDSi | CCDS41448.1 |
RefSeqi | NP_001034241.1, NM_001039152.3 |
Genome annotation databases
Ensembli | ENST00000417209; ENSP00000428343; ENSG00000253148 |
GeneIDi | 431704 |
KEGGi | hsa:431704 |
UCSCi | uc001gsh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY643711 mRNA Translation: AAT64913.1 |
CCDSi | CCDS41448.1 |
RefSeqi | NP_001034241.1, NM_001039152.3 |
3D structure databases
SMRi | Q2M5E4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428343 |
PTM databases
iPTMneti | Q2M5E4 |
PhosphoSitePlusi | Q2M5E4 |
Genetic variation databases
BioMutai | RGS21 |
DMDMi | 121941516 |
Proteomic databases
PaxDbi | Q2M5E4 |
PeptideAtlasi | Q2M5E4 |
PRIDEi | Q2M5E4 |
ProteomicsDBi | 61388 |
Protocols and materials databases
Antibodypediai | 58786, 70 antibodies |
DNASUi | 431704 |
Genome annotation databases
Ensembli | ENST00000417209; ENSP00000428343; ENSG00000253148 |
GeneIDi | 431704 |
KEGGi | hsa:431704 |
UCSCi | uc001gsh.4, human |
Organism-specific databases
CTDi | 431704 |
DisGeNETi | 431704 |
GeneCardsi | RGS21 |
HGNCi | HGNC:26839, RGS21 |
HPAi | ENSG00000253148, Not detected |
MIMi | 612407, gene |
neXtProti | NX_Q2M5E4 |
OpenTargetsi | ENSG00000253148 |
PharmGKBi | PA134875582 |
VEuPathDBi | HostDB:ENSG00000253148.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161004 |
HOGENOMi | CLU_059863_1_5_1 |
InParanoidi | Q2M5E4 |
OMAi | VKGRCCF |
OrthoDBi | 1246872at2759 |
PhylomeDBi | Q2M5E4 |
TreeFami | TF315837 |
Enzyme and pathway databases
PathwayCommonsi | Q2M5E4 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 431704, 4 hits in 971 CRISPR screens |
GenomeRNAii | 431704 |
Pharosi | Q2M5E4, Tdark |
PROi | PR:Q2M5E4 |
RNActi | Q2M5E4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000253148, Expressed in subventricular zone (inner) (primate) and 2 other tissues |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS21_HUMAN | |
Accessioni | Q2M5E4Primary (citable) accession number: Q2M5E4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | February 21, 2006 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot