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Protein

Regulator of G-protein signaling 21

Gene

RGS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 21
Short name:
RGS21
Gene namesi
Name:RGS21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000253148.1
HGNCiHGNC:26839 RGS21
MIMi612407 gene
neXtProtiNX_Q2M5E4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi431704
OpenTargetsiENSG00000253148
PharmGKBiPA134875582

Polymorphism and mutation databases

BioMutaiRGS21
DMDMi121941516

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713751 – 152Regulator of G-protein signaling 21Add BLAST152

Proteomic databases

PaxDbiQ2M5E4
PeptideAtlasiQ2M5E4
PRIDEiQ2M5E4
ProteomicsDBi61388

PTM databases

iPTMnetiQ2M5E4
PhosphoSitePlusiQ2M5E4

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_RGS21

Organism-specific databases

HPAiHPA052843

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000428343

Structurei

3D structure databases

ProteinModelPortaliQ2M5E4
SMRiQ2M5E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 137RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ2M5E4
KOiK16449
OMAiCCFYRSP
OrthoDBiEOG091G0BDG
PhylomeDBiQ2M5E4
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q2M5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF
60 70 80 90 100
WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI
110 120 130 140 150
AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP

FL
Length:152
Mass (Da):17,671
Last modified:February 21, 2006 - v1
Checksum:iD9EF097E89CA9731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY643711 mRNA Translation: AAT64913.1
CCDSiCCDS41448.1
RefSeqiNP_001034241.1, NM_001039152.3
UniGeneiHs.558673

Genome annotation databases

EnsembliENST00000417209; ENSP00000428343; ENSG00000253148
GeneIDi431704
KEGGihsa:431704
UCSCiuc001gsh.4 human

Similar proteinsi

Entry informationi

Entry nameiRGS21_HUMAN
AccessioniPrimary (citable) accession number: Q2M5E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: June 20, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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