UniProtKB - Q2M3X9 (ZN674_HUMAN)
Protein
Zinc finger protein 674
Gene
ZNF674
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Caution
Although ZNF674 has been reported to be involved in X-linked mental retardation (PubMed:16385466), its pathological role is questionable (PubMed:23871722).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 224 – 246 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 252 – 274 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 553 – 575 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q2M3X9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 674 |
Gene namesi | Name:ZNF674 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17625, ZNF674 |
MIMi | 300573, gene |
neXtProti | NX_Q2M3X9 |
VEuPathDBi | HostDB:ENSG00000251192.7 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 641339 |
OpenTargetsi | ENSG00000251192 |
PharmGKBi | PA142670475 |
Miscellaneous databases
Pharosi | Q2M3X9, Tdark |
Genetic variation databases
BioMutai | ZNF674 |
DMDMi | 94730686 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233995 | 1 – 581 | Zinc finger protein 674Add BLAST | 581 |
Proteomic databases
jPOSTi | Q2M3X9 |
MassIVEi | Q2M3X9 |
MaxQBi | Q2M3X9 |
PaxDbi | Q2M3X9 |
PeptideAtlasi | Q2M3X9 |
PRIDEi | Q2M3X9 |
ProteomicsDBi | 20582 61387 [Q2M3X9-1] |
PTM databases
iPTMneti | Q2M3X9 |
PhosphoSitePlusi | Q2M3X9 |
Expressioni
Tissue specificityi
Expressed in testis.1 Publication
Developmental stagei
Expressed in fetal brain.1 Publication
Gene expression databases
Bgeei | ENSG00000251192, Expressed in vastus lateralis and 125 other tissues |
ExpressionAtlasi | Q2M3X9, baseline and differential |
Genevisiblei | Q2M3X9, HS |
Organism-specific databases
HPAi | ENSG00000251192, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 534961, 1 interactor |
IntActi | Q2M3X9, 1 interactor |
STRINGi | 9606.ENSP00000429148 |
Miscellaneous databases
RNActi | Q2M3X9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 224 – 246 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 252 – 274 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 553 – 575 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162233 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q2M3X9 |
OMAi | TSEKPEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q2M3X9 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2M3X9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGHL
60 70 80 90 100
VGKPDVIFRL GPGDESWMAD GGTPVRTCAG EDRPEVWEVD EQIDHYKESQ
110 120 130 140 150
DKFLWQAAFI GKETLKDESG QECKICRKII YLNTDFVSVK QRLPKYYSWE
160 170 180 190 200
RCSKHHLNFL GQNRSYVRKK DDGCKAYWKV CLHYNLHKAQ PAERFFDPNQ
210 220 230 240 250
RGKALHQKQA LRKSQRSQTG EKLYKCTECG KVFIQKANLV VHQRTHTGEK
260 270 280 290 300
PYECCECAKA FSQKSTLIAH QRTHTGEKPY ECSECGKTFI QKSTLIKHQR
310 320 330 340 350
THTGEKPFVC DKCPKAFKSS YHLIRHEKTH IRQAFYKGIK CTTSSLIYQR
360 370 380 390 400
IHTSEKPQCS EHGKASDEKP SPTKHWRTHT KENIYECSKC GKSFRGKSHL
410 420 430 440 450
SVHQRIHTGE KPYECSICGK TFSGKSHLSV HHRTHTGEKP YECRRCGKAF
460 470 480 490 500
GEKSTLIVHQ RMHTGEKPYK CNECGKAFSE KSPLIKHQRI HTGERPYECT
510 520 530 540 550
DCKKAFSRKS TLIKHQRIHT GEKPYKCSEC GKAFSVKSTL IVHHRTHTGE
560 570 580
KPYECRDCGK AFSGKSTLIK HQRSHTGDKN L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RHV3 | E5RHV3_HUMAN | Zinc finger protein 674 | ZNF674 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 222 | K → R in BAG58103 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046997 | 182 | L → F. Corresponds to variant dbSNP:rs1737367Ensembl. | 1 | |
Natural variantiVAR_026152 | 343 | T → M1 PublicationCorresponds to variant dbSNP:rs61730637EnsemblClinVar. | 1 | |
Natural variantiVAR_026153 | 412 | P → L Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1422964788Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044562 | 80 – 85 | Missing in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY971607 mRNA Translation: AAY40800.1 AK295054 mRNA Translation: BAG58103.1 AL022165 Genomic DNA No translation available. AL031393 Genomic DNA No translation available. |
CCDSi | CCDS48099.1 [Q2M3X9-1] CCDS55406.1 [Q2M3X9-2] |
RefSeqi | NP_001034980.1, NM_001039891.2 [Q2M3X9-1] NP_001139763.1, NM_001146291.1 [Q2M3X9-2] NP_001177346.1, NM_001190417.1 XP_011542243.1, XM_011543941.2 [Q2M3X9-1] |
Genome annotation databases
Ensembli | ENST00000414387; ENSP00000428248; ENSG00000251192 [Q2M3X9-2] ENST00000523374; ENSP00000429148; ENSG00000251192 [Q2M3X9-1] |
GeneIDi | 641339 |
KEGGi | hsa:641339 |
UCSCi | uc004dgr.4, human [Q2M3X9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY971607 mRNA Translation: AAY40800.1 AK295054 mRNA Translation: BAG58103.1 AL022165 Genomic DNA No translation available. AL031393 Genomic DNA No translation available. |
CCDSi | CCDS48099.1 [Q2M3X9-1] CCDS55406.1 [Q2M3X9-2] |
RefSeqi | NP_001034980.1, NM_001039891.2 [Q2M3X9-1] NP_001139763.1, NM_001146291.1 [Q2M3X9-2] NP_001177346.1, NM_001190417.1 XP_011542243.1, XM_011543941.2 [Q2M3X9-1] |
3D structure databases
SMRi | Q2M3X9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 534961, 1 interactor |
IntActi | Q2M3X9, 1 interactor |
STRINGi | 9606.ENSP00000429148 |
PTM databases
iPTMneti | Q2M3X9 |
PhosphoSitePlusi | Q2M3X9 |
Genetic variation databases
BioMutai | ZNF674 |
DMDMi | 94730686 |
Proteomic databases
jPOSTi | Q2M3X9 |
MassIVEi | Q2M3X9 |
MaxQBi | Q2M3X9 |
PaxDbi | Q2M3X9 |
PeptideAtlasi | Q2M3X9 |
PRIDEi | Q2M3X9 |
ProteomicsDBi | 20582 61387 [Q2M3X9-1] |
Protocols and materials databases
Antibodypediai | 47866, 92 antibodies |
DNASUi | 641339 |
Genome annotation databases
Ensembli | ENST00000414387; ENSP00000428248; ENSG00000251192 [Q2M3X9-2] ENST00000523374; ENSP00000429148; ENSG00000251192 [Q2M3X9-1] |
GeneIDi | 641339 |
KEGGi | hsa:641339 |
UCSCi | uc004dgr.4, human [Q2M3X9-1] |
Organism-specific databases
CTDi | 641339 |
DisGeNETi | 641339 |
GeneCardsi | ZNF674 |
HGNCi | HGNC:17625, ZNF674 |
HPAi | ENSG00000251192, Low tissue specificity |
MIMi | 300573, gene |
neXtProti | NX_Q2M3X9 |
OpenTargetsi | ENSG00000251192 |
PharmGKBi | PA142670475 |
VEuPathDBi | HostDB:ENSG00000251192.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162233 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q2M3X9 |
OMAi | TSEKPEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q2M3X9 |
TreeFami | TF337898 |
Enzyme and pathway databases
PathwayCommonsi | Q2M3X9 |
Miscellaneous databases
BioGRID-ORCSi | 641339, 13 hits in 634 CRISPR screens |
ChiTaRSi | ZNF674, human |
GenomeRNAii | 641339 |
Pharosi | Q2M3X9, Tdark |
PROi | PR:Q2M3X9 |
RNActi | Q2M3X9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000251192, Expressed in vastus lateralis and 125 other tissues |
ExpressionAtlasi | Q2M3X9, baseline and differential |
Genevisiblei | Q2M3X9, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN674_HUMAN | |
Accessioni | Q2M3X9Primary (citable) accession number: Q2M3X9 Secondary accession number(s): B4DHE2, E9PHQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | February 21, 2006 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families