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UniProtKB - Q2M3X9 (ZN674_HUMAN)

Entry version 120 (13 Feb 2019)
Sequence version 1 (21 Feb 2006)
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Protein

Zinc finger protein 674

Gene

ZNF674

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Caution

Although ZNF674 has been reported to be involved in X-linked mental retardation (PubMed:16385466), its pathological role is questionable (PubMed:23871722).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri224 – 246C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 674
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF674
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000251192.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:17625 ZNF674

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300573 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2M3X9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		641339

MalaCards human disease database

More...MalaCardsi		ZNF674

Open Targets

More...OpenTargetsi		ENSG00000251192

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670475

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF674

Domain mapping of disease mutations (DMDM)

More...DMDMi		94730686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339951 – 581Zinc finger protein 674Add BLAST581

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2M3X9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2M3X9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2M3X9

PeptideAtlas

More...PeptideAtlasi		Q2M3X9

PRoteomics IDEntifications database

More...PRIDEi		Q2M3X9

ProteomicsDB human proteome resource

More...ProteomicsDBi		61387

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2M3X9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2M3X9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000251192 Expressed in 99 organ(s), highest expression level in vastus lateralis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q2M3X9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2M3X9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA031026
HPA065295

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q2M3X9, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000429148

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q2M3X9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2M3X9

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri224 – 246C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2M3X9

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		SVHHRTH

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2M3X9

TreeFam database of animal gene trees

More...TreeFami		TF337898

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2M3X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGHL 
        60         70         80         90        100
VGKPDVIFRL GPGDESWMAD GGTPVRTCAG EDRPEVWEVD EQIDHYKESQ 
       110        120        130        140        150
DKFLWQAAFI GKETLKDESG QECKICRKII YLNTDFVSVK QRLPKYYSWE 
       160        170        180        190        200
RCSKHHLNFL GQNRSYVRKK DDGCKAYWKV CLHYNLHKAQ PAERFFDPNQ 
       210        220        230        240        250
RGKALHQKQA LRKSQRSQTG EKLYKCTECG KVFIQKANLV VHQRTHTGEK 
       260        270        280        290        300
PYECCECAKA FSQKSTLIAH QRTHTGEKPY ECSECGKTFI QKSTLIKHQR 
       310        320        330        340        350
THTGEKPFVC DKCPKAFKSS YHLIRHEKTH IRQAFYKGIK CTTSSLIYQR 
       360        370        380        390        400
IHTSEKPQCS EHGKASDEKP SPTKHWRTHT KENIYECSKC GKSFRGKSHL 
       410        420        430        440        450
SVHQRIHTGE KPYECSICGK TFSGKSHLSV HHRTHTGEKP YECRRCGKAF 
       460        470        480        490        500
GEKSTLIVHQ RMHTGEKPYK CNECGKAFSE KSPLIKHQRI HTGERPYECT 
       510        520        530        540        550
DCKKAFSRKS TLIKHQRIHT GEKPYKCSEC GKAFSVKSTL IVHHRTHTGE 
       560        570        580 
KPYECRDCGK AFSGKSTLIK HQRSHTGDKN L
Length:581
Mass (Da):67,199
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DBD560342DE250D
GO
Isoform 2 (identifier: Q2M3X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-85: Missing.

Note: No experimental confirmation available.
Show »
Length:575
Mass (Da):66,515
Checksum:iC3A93744B086D1AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHV3E5RHV3_HUMAN
Zinc finger protein 674
ZNF674
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222K → R in BAG58103 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046997182L → F. Corresponds to variant dbSNP:rs1737367Ensembl.1
Natural variantiVAR_026152343T → M1 PublicationCorresponds to variant dbSNP:rs61730637EnsemblClinVar.1
Natural variantiVAR_026153412P → L Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1422964788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04456280 – 85Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY971607 mRNA Translation: AAY40800.1
AK295054 mRNA Translation: BAG58103.1
AL022165 Genomic DNA No translation available.
AL031393 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48099.1 [Q2M3X9-1]
CCDS55406.1 [Q2M3X9-2]

NCBI Reference Sequences

More...RefSeqi		NP_001034980.1, NM_001039891.2 [Q2M3X9-1]
NP_001139763.1, NM_001146291.1 [Q2M3X9-2]
NP_001177346.1, NM_001190417.1
XP_011542243.1, XM_011543941.2 [Q2M3X9-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.636105

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000414387; ENSP00000428248; ENSG00000251192 [Q2M3X9-2]
ENST00000523374; ENSP00000429148; ENSG00000251192 [Q2M3X9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		641339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:641339

UCSC genome browser

More...UCSCi		uc004dgr.4 human [Q2M3X9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY971607 mRNA Translation: AAY40800.1
AK295054 mRNA Translation: BAG58103.1
AL022165 Genomic DNA No translation available.
AL031393 Genomic DNA No translation available.
CCDSiCCDS48099.1 [Q2M3X9-1]
CCDS55406.1 [Q2M3X9-2]
RefSeqiNP_001034980.1, NM_001039891.2 [Q2M3X9-1]
NP_001139763.1, NM_001146291.1 [Q2M3X9-2]
NP_001177346.1, NM_001190417.1
XP_011542243.1, XM_011543941.2 [Q2M3X9-1]
UniGeneiHs.636105

3D structure databases

ProteinModelPortaliQ2M3X9
SMRiQ2M3X9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2M3X9, 1 interactor
STRINGi9606.ENSP00000429148

PTM databases

iPTMnetiQ2M3X9
PhosphoSitePlusiQ2M3X9

Polymorphism and mutation databases

BioMutaiZNF674
DMDMi94730686

Proteomic databases

jPOSTiQ2M3X9
MaxQBiQ2M3X9
PaxDbiQ2M3X9
PeptideAtlasiQ2M3X9
PRIDEiQ2M3X9
ProteomicsDBi61387

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		641339
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414387; ENSP00000428248; ENSG00000251192 [Q2M3X9-2]
ENST00000523374; ENSP00000429148; ENSG00000251192 [Q2M3X9-1]
GeneIDi641339
KEGGihsa:641339
UCSCiuc004dgr.4 human [Q2M3X9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		641339
DisGeNETi641339
EuPathDBiHostDB:ENSG00000251192.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF674
HGNCiHGNC:17625 ZNF674
HPAiHPA031026
HPA065295
MalaCardsiZNF674
MIMi300573 gene
neXtProtiNX_Q2M3X9
OpenTargetsiENSG00000251192
PharmGKBiPA142670475

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162233
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ2M3X9
KOiK09228
OMAiSVHHRTH
OrthoDBi172471at2759
PhylomeDBiQ2M3X9
TreeFamiTF337898

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF674 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		641339

Protein Ontology

More...PROi		PR:Q2M3X9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000251192 Expressed in 99 organ(s), highest expression level in vastus lateralis
ExpressionAtlasiQ2M3X9 baseline and differential
GenevisibleiQ2M3X9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN674_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M3X9
Secondary accession number(s): B4DHE2, E9PHQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 21, 2006
Last modified: February 13, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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