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Protein

Ankyrin repeat domain-containing protein SOWAHA

Gene

SOWAHA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHA
Alternative name(s):
Ankyrin repeat domain-containing protein 43
Protein sosondowah homolog A
Gene namesi
Name:SOWAHA
Synonyms:ANKRD43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000198944.5
HGNCiHGNC:27033 SOWAHA
neXtProtiNX_Q2M3V2

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672610

Polymorphism and mutation databases

BioMutaiSOWAHA
DMDMi296439442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000024437318 – 549Ankyrin repeat domain-containing protein SOWAHAAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2M3V2
PeptideAtlasiQ2M3V2
PRIDEiQ2M3V2
ProteomicsDBi61383

PTM databases

iPTMnetiQ2M3V2
PhosphoSitePlusiQ2M3V2

Expressioni

Gene expression databases

BgeeiENSG00000198944 Expressed in 124 organ(s), highest expression level in caudate nucleus
CleanExiHS_ANKRD43
GenevisibleiQ2M3V2 HS

Organism-specific databases

HPAiHPA064621

Interactioni

Protein-protein interaction databases

IntActiQ2M3V2, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ2M3V2
SMRiQ2M3V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati345 – 374ANK 1Add BLAST30
Repeati384 – 414ANK 2Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 309Pro-richAdd BLAST227

Sequence similaritiesi

Belongs to the SOWAH family.Curated

Keywords - Domaini

ANK repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH41 Eukaryota
ENOG410YDPM LUCA
HOGENOMiHOG000033965
HOVERGENiHBG100446
InParanoidiQ2M3V2
OrthoDBiEOG091G0F4O
PhylomeDBiQ2M3V2
TreeFamiTF331362

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2M3V2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALAAAAAAA AAGVSQAAVL GFLQEHGGKV RNSELLSRFK PLLDAGDPRG
60 70 80 90 100
RAARRDRFKQ FVNNVAVVKE LDGVKFVVLR KKPRPPEPEP APFGPPGAAA
110 120 130 140 150
QPSKPTSTVL PRSASAPGAP PLVRVPRPVE PPGDLGLPTE PQDTPGGPAS
160 170 180 190 200
EPAQPPGERS ADPPLPALEL AQATERPSAD AAPPPRAPSE AASPCSDPPD
210 220 230 240 250
AEPGPGAAKG PPQQKPCMLP VRCVPAPATL RLRAEEPGLR RQLSEEPSPR
260 270 280 290 300
SSPLLLRRLS VEESGLGLGL GPGRSPHLRR LSRAGPRLLS PDAEELPAAP
310 320 330 340 350
PPSAVPLEPS EHEWLVRTAG GRWTHQLHGL LLRDRGLAAK RDFMSGFTAL
360 370 380 390 400
HWAAKSGDGE MALQLVEVAR RSGAPVDVNA RSHGGYTPLH LAALHGHEDA
410 420 430 440 450
AVLLVVRLGA QVHVRDHSGR RAYQYLRPGS SYALRRLLGD PGLRGTTEPD
460 470 480 490 500
ATGGGSGSLA ARRPVQVAAT ILSSTTSAFL GVLADDLMLQ DLARGLKKSS
510 520 530 540
SFSKFLSASP MAPRKKTKIR GGLPAFSEIS RRPTPGPLAG LVPSFPPTT
Length:549
Mass (Da):57,443
Last modified:May 18, 2010 - v3
Checksum:i07401B2E2F134F6C
GO

Sequence cautioni

The sequence AAI04772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI04776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03975 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059125124R → P. Corresponds to variant dbSNP:rs40274Ensembl.1
Natural variantiVAR_060465545F → L2 PublicationsCorresponds to variant dbSNP:rs40470Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA No translation available.
BC104771 mRNA Translation: AAI04772.1 Different initiation.
BC104775 mRNA Translation: AAI04776.1 Different initiation.
AK092782 mRNA Translation: BAC03975.1 Different initiation.
CCDSiCCDS43361.1
UniGeneiHs.13308

Genome annotation databases

EnsembliENST00000378693; ENSP00000367965; ENSG00000198944
UCSCiuc003kxw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA No translation available.
BC104771 mRNA Translation: AAI04772.1 Different initiation.
BC104775 mRNA Translation: AAI04776.1 Different initiation.
AK092782 mRNA Translation: BAC03975.1 Different initiation.
CCDSiCCDS43361.1
UniGeneiHs.13308

3D structure databases

ProteinModelPortaliQ2M3V2
SMRiQ2M3V2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2M3V2, 1 interactor

PTM databases

iPTMnetiQ2M3V2
PhosphoSitePlusiQ2M3V2

Polymorphism and mutation databases

BioMutaiSOWAHA
DMDMi296439442

Proteomic databases

PaxDbiQ2M3V2
PeptideAtlasiQ2M3V2
PRIDEiQ2M3V2
ProteomicsDBi61383

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378693; ENSP00000367965; ENSG00000198944
UCSCiuc003kxw.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000198944.5
GeneCardsiSOWAHA
H-InvDBiHIX0005161
HIX0164324
HGNCiHGNC:27033 SOWAHA
HPAiHPA064621
neXtProtiNX_Q2M3V2
PharmGKBiPA142672610
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH41 Eukaryota
ENOG410YDPM LUCA
HOGENOMiHOG000033965
HOVERGENiHBG100446
InParanoidiQ2M3V2
OrthoDBiEOG091G0F4O
PhylomeDBiQ2M3V2
TreeFamiTF331362

Miscellaneous databases

PROiPR:Q2M3V2

Gene expression databases

BgeeiENSG00000198944 Expressed in 124 organ(s), highest expression level in caudate nucleus
CleanExiHS_ANKRD43
GenevisibleiQ2M3V2 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSWAHA_HUMAN
AccessioniPrimary (citable) accession number: Q2M3V2
Secondary accession number(s): Q8NAE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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