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Protein

Solute carrier family 35 member G1

Gene

SLC35G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.1 Publication

GO - Biological processi

  • calcium ion export across plasma membrane Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: UniProtKB

Protein family/group databases

TCDBi2.A.7.28.8 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G1
Alternative name(s):
Partner of STIM1
Transmembrane protein 20
Gene namesi
Name:SLC35G1
Synonyms:C10orf60, POST, TMEM20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176273.14
HGNCiHGNC:26607 SLC35G1
MIMi617167 gene
neXtProtiNX_Q2M3R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei311 – 333HelicalSequence analysisAdd BLAST23
Transmembranei338 – 357HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi159371
OpenTargetsiENSG00000176273
PharmGKBiPA134933626

Polymorphism and mutation databases

BioMutaiSLC35G1
DMDMi109895215

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444631 – 365Solute carrier family 35 member G1Add BLAST365

Proteomic databases

MaxQBiQ2M3R5
PaxDbiQ2M3R5
PeptideAtlasiQ2M3R5
PRIDEiQ2M3R5
ProteomicsDBi61380
61381 [Q2M3R5-2]

PTM databases

iPTMnetiQ2M3R5
PhosphoSitePlusiQ2M3R5

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000176273
CleanExiHS_TMEM20
ExpressionAtlasiQ2M3R5 baseline and differential
GenevisibleiQ2M3R5 HS

Interactioni

Subunit structurei

Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.1 Publication

Protein-protein interaction databases

BioGridi127741, 1 interactor
IntActiQ2M3R5, 1 interactor
STRINGi9606.ENSP00000400932

Structurei

3D structure databases

ProteinModelPortaliQ2M3R5
SMRiQ2M3R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 202EamA 1Add BLAST123
Domaini233 – 357EamA 2Add BLAST125

Sequence similaritiesi

Belongs to the TMEM20 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4510 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00730000111035
HOGENOMiHOG000045867
HOVERGENiHBG094068
InParanoidiQ2M3R5
OMAiEYTRIVW
OrthoDBiEOG091G0AJI
PhylomeDBiQ2M3R5
TreeFamiTF323956

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
PfamiView protein in Pfam
PF00892 EamA, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQDSTGVA ELQEPGLPLT DDAPPGATEE PAAAEAAGAP DRGRCWLCLS
60 70 80 90 100
SPCCSRTEPE AKKKAPCPGL GLFYTLLSAF LFSVGSLFVK KVQDVHAVEI
110 120 130 140 150
SAFRCVFQML VVIPCLIYRK TGFIGPKGQR IFLILRGVLG STAMMLIYYA
160 170 180 190 200
YQTMSLADAT VITFSSPVFT SIFAWICLKE KYSPWDALFT VFTITGVILI
210 220 230 240 250
VRPPFLFGSD TSGMEESYSG HLKGTFAAIG SAVFAASTLV ILRKMGKSVD
260 270 280 290 300
YFLSIWYYVV LGLVESVIIL SVLGEWSLPY CGLDRLFLIF IGLFGLGGQI
310 320 330 340 350
FITKALQIEK AGPVAIMKTM DVVFAFIFQI IFFNNVPTWW TVGGALCVVA
360
SNVGAAIRKW YQSSK
Length:365
Mass (Da):39,836
Last modified:February 21, 2006 - v1
Checksum:iB2B19AEFF5DFFB93
GO
Isoform 2 (identifier: Q2M3R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):39,707
Checksum:i62CAF8E3B933EC26
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01956660Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091309 mRNA Translation: BAC03633.1
AL138923 Genomic DNA No translation available.
BC041432 mRNA Translation: AAH41432.1
BC104814 mRNA Translation: AAI04815.1
CCDSiCCDS44459.1 [Q2M3R5-1]
CCDS7432.1 [Q2M3R5-2]
RefSeqiNP_001128130.1, NM_001134658.2 [Q2M3R5-1]
NP_694958.1, NM_153226.3 [Q2M3R5-2]
UniGeneiHs.632085
Hs.744369

Genome annotation databases

EnsembliENST00000371408; ENSP00000360462; ENSG00000176273 [Q2M3R5-2]
ENST00000427197; ENSP00000400932; ENSG00000176273 [Q2M3R5-1]
GeneIDi159371
KEGGihsa:159371
UCSCiuc001kjf.3 human [Q2M3R5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35G1_HUMAN
AccessioniPrimary (citable) accession number: Q2M3R5
Secondary accession number(s): Q86YG5, Q8NBA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 21, 2006
Last modified: June 20, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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