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Entry version 121 (16 Oct 2019)
Sequence version 2 (20 May 2008)
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Protein

Sodium/glucose cotransporter 4

Gene

SLC5A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189200 Cellular hexose transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.3.17 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/glucose cotransporter 4
Short name:
Na(+)/glucose cotransporter 4
Short name:
hSGLT4
Alternative name(s):
Solute carrier family 5 member 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A9
Synonyms:SGLT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22146 SLC5A9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M3M2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 75CytoplasmicSequence analysisAdd BLAST18
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 114ExtracellularSequence analysisAdd BLAST16
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 190ExtracellularSequence analysisAdd BLAST12
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 217CytoplasmicSequence analysis6
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 275ExtracellularSequence analysisAdd BLAST37
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 317CytoplasmicSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 383ExtracellularSequence analysisAdd BLAST45
Transmembranei384 – 406HelicalSequence analysisAdd BLAST23
Topological domaini407 – 427CytoplasmicSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 459ExtracellularSequence analysisAdd BLAST11
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 487CytoplasmicSequence analysis7
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 530ExtracellularSequence analysisAdd BLAST22
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 660CytoplasmicSequence analysisAdd BLAST109
Transmembranei661 – 681HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000117834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134949681

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2M3M2

Chemistry databases

DrugCentral

More...
DrugCentrali
Q2M3M2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC5A9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189046189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003338051 – 681Sodium/glucose cotransporter 4Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei604PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q2M3M2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2M3M2

PeptideAtlas

More...
PeptideAtlasi
Q2M3M2

PRoteomics IDEntifications database

More...
PRIDEi
Q2M3M2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19032
20981
61379 [Q2M3M2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M3M2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M3M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the small intestine, kidney and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117834 Expressed in 107 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2M3M2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2M3M2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050263

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128290, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000236495

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP49 Eukaryota
COG4146 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000025422

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2M3M2

KEGG Orthology (KO)

More...
KOi
K14389

Identification of Orthologs from Complete Genome Data

More...
OMAi
TINVFLW

Database of Orthologous Groups

More...
OrthoDBi
243316at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2M3M2

TreeFam database of animal gene trees

More...
TreeFami
TF352855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2M3M2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA
60 70 80 90 100
VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG
110 120 130 140 150
AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI
160 170 180 190 200
QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY
210 220 230 240 250
TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP
260 270 280 290 300
NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV
310 320 330 340 350
IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV
360 370 380 390 400
DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS
410 420 430 440 450
IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS
460 470 480 490 500
SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG
510 520 530 540 550
LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL
560 570 580 590 600
CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA
610 620 630 640 650
AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT
660 670 680
SIEEEPLWRH VCNINAVLLL AINIFLWGYF A
Length:681
Mass (Da):74,073
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i618D27DC590EE826
GO
Isoform 2 (identifier: Q2M3M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTGVRSQ

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):76,831
Checksum:i054FA1D2DA1CF772
GO
Isoform 3 (identifier: Q2M3M2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTG

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):76,361
Checksum:i5DA45BB64BE95391
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD86F8WD86_HUMAN
Sodium/glucose cotransporter 4
SLC5A9
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5P9H0Y5P9_HUMAN
Sodium/glucose cotransporter 4
SLC5A9
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC92H0YC92_HUMAN
Sodium/glucose cotransporter 4
SLC5A9
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068963124V → I1 PublicationCorresponds to variant dbSNP:rs141515954Ensembl.1
Natural variantiVAR_043166152V → M. Corresponds to variant dbSNP:rs212989Ensembl.1
Natural variantiVAR_043167207M → T. Corresponds to variant dbSNP:rs12047252Ensembl.1
Natural variantiVAR_043168269I → M3 PublicationsCorresponds to variant dbSNP:rs212991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044577113N → NMRKSRSGGDRGIHPRSHGR TGVRSQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_057168113N → NMRKSRSGGDRGIHPRSHGR TG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131200 mRNA Translation: BAG54749.1
AL109659 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06857.1
BC104857 mRNA Translation: AAI04858.1
BC104863 mRNA Translation: AAI04864.1
BC143570 mRNA Translation: AAI43571.1
BC143572 mRNA Translation: AAI43573.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30709.2 [Q2M3M2-1]
CCDS44136.1 [Q2M3M2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001011547.2, NM_001011547.2 [Q2M3M2-1]
NP_001128653.1, NM_001135181.1 [Q2M3M2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236495; ENSP00000236495; ENSG00000117834 [Q2M3M2-2]
ENST00000438567; ENSP00000401730; ENSG00000117834 [Q2M3M2-1]
ENST00000533824; ENSP00000431900; ENSG00000117834 [Q2M3M2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
200010

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200010

UCSC genome browser

More...
UCSCi
uc001crn.3 human [Q2M3M2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131200 mRNA Translation: BAG54749.1
AL109659 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06857.1
BC104857 mRNA Translation: AAI04858.1
BC104863 mRNA Translation: AAI04864.1
BC143570 mRNA Translation: AAI43571.1
BC143572 mRNA Translation: AAI43573.1
CCDSiCCDS30709.2 [Q2M3M2-1]
CCDS44136.1 [Q2M3M2-2]
RefSeqiNP_001011547.2, NM_001011547.2 [Q2M3M2-1]
NP_001128653.1, NM_001135181.1 [Q2M3M2-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi128290, 2 interactors
STRINGi9606.ENSP00000236495

Chemistry databases

DrugCentraliQ2M3M2

Protein family/group databases

TCDBi2.A.21.3.17 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiQ2M3M2
PhosphoSitePlusiQ2M3M2

Polymorphism and mutation databases

BioMutaiSLC5A9
DMDMi189046189

Proteomic databases

MassIVEiQ2M3M2
PaxDbiQ2M3M2
PeptideAtlasiQ2M3M2
PRIDEiQ2M3M2
ProteomicsDBi19032
20981
61379 [Q2M3M2-1]

Genome annotation databases

EnsembliENST00000236495; ENSP00000236495; ENSG00000117834 [Q2M3M2-2]
ENST00000438567; ENSP00000401730; ENSG00000117834 [Q2M3M2-1]
ENST00000533824; ENSP00000431900; ENSG00000117834 [Q2M3M2-3]
GeneIDi200010
KEGGihsa:200010
UCSCiuc001crn.3 human [Q2M3M2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
200010

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC5A9
HGNCiHGNC:22146 SLC5A9
HPAiHPA050263
neXtProtiNX_Q2M3M2
OpenTargetsiENSG00000117834
PharmGKBiPA134949681

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00940000157546
HOGENOMiHOG000025422
InParanoidiQ2M3M2
KOiK14389
OMAiTINVFLW
OrthoDBi243316at2759
PhylomeDBiQ2M3M2
TreeFamiTF352855

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
200010
PharosiQ2M3M2

Protein Ontology

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PROi
PR:Q2M3M2

Gene expression databases

BgeeiENSG00000117834 Expressed in 107 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiQ2M3M2 baseline and differential
GenevisibleiQ2M3M2 HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M3M2
Secondary accession number(s): B3KY87
, B7ZL45, B7ZL47, E9PAK4, E9PJ08, Q5TET3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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