UniProtKB - Q2M3G4 (SHRM1_HUMAN)
Protein
Protein Shroom1
Gene
SHROOM1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the assembly of microtubule arrays during cell elongation.By similarity
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- myosin II binding Source: UniProtKB
GO - Biological processi
- actin filament bundle assembly Source: UniProtKB
- actin filament organization Source: GO_Central
- cell morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q2M3G4 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Shroom1Alternative name(s): Apical protein 2 |
Gene namesi | Name:SHROOM1 Synonyms:APXL2, KIAA1960 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24084, SHROOM1 |
MIMi | 611179, gene |
neXtProti | NX_Q2M3G4 |
VEuPathDBi | HostDB:ENSG00000164403.14 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
- microtubule Source: UniProtKB-KW
Plasma Membrane
- apical plasma membrane Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- apical junction complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 134549 |
OpenTargetsi | ENSG00000164403 |
PharmGKBi | PA147357345 |
Miscellaneous databases
Pharosi | Q2M3G4, Tdark |
Genetic variation databases
BioMutai | SHROOM1 |
DMDMi | 121941488 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286061 | 1 – 852 | Protein Shroom1Add BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 133 | PhosphoserineCombined sources | 1 | |
Modified residuei | 137 | PhosphoserineCombined sources | 1 | |
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q2M3G4 |
jPOSTi | Q2M3G4 |
MassIVEi | Q2M3G4 |
MaxQBi | Q2M3G4 |
PaxDbi | Q2M3G4 |
PeptideAtlasi | Q2M3G4 |
PRIDEi | Q2M3G4 |
ProteomicsDBi | 61376 [Q2M3G4-1] 61377 [Q2M3G4-2] |
PTM databases
iPTMneti | Q2M3G4 |
PhosphoSitePlusi | Q2M3G4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164403, Expressed in urinary bladder and 210 other tissues |
ExpressionAtlasi | Q2M3G4, baseline and differential |
Genevisiblei | Q2M3G4, HS |
Organism-specific databases
HPAi | ENSG00000164403, Tissue enhanced (liver, urinary bladder) |
Interactioni
Subunit structurei
Interacts with F-actin.
By similarityGO - Molecular functioni
- actin filament binding Source: UniProtKB
- myosin II binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 126408, 8 interactors |
DIPi | DIP-42367N |
IntActi | Q2M3G4, 10 interactors |
MINTi | Q2M3G4 |
STRINGi | 9606.ENSP00000367950 |
Miscellaneous databases
RNActi | Q2M3G4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 233 | ASD1PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 543 – 825 | ASD2PROSITE-ProRule annotationAdd BLAST | 283 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 713 – 719 | Poly-Leu | 7 |
Domaini
The ASD1 domain mediates F-actin binding.By similarity
Sequence similaritiesi
Belongs to the shroom family.Curated
Phylogenomic databases
eggNOGi | ENOG502SM3B, Eukaryota |
GeneTreei | ENSGT00940000160656 |
InParanoidi | Q2M3G4 |
OMAi | VSRPTCC |
OrthoDBi | 729991at2759 |
PhylomeDBi | Q2M3G4 |
TreeFami | TF335754 |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 2 hits |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2M3G4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALGPGGDR ASPASSTSSL DLWHLSMRAD SAYSSFSAAS GGPEPRTQSP
60 70 80 90 100
GTDLLPYLDW DYVRVVWGGP GPAPPDAALC TSPRPRPAVA ARSGPQPTEV
110 120 130 140 150
PGTPGPLNRQ ATPLLYALAA EAEAAAQAAE PPSPPASRAA YRQRLQGAQR
160 170 180 190 200
RVLRETSFQR KELRMSLPAR LRPTVPARPP ATHPRSASLS HPGGEGEPAR
210 220 230 240 250
SRAPAPGTAG RGPLANQQRK WCFSEPGKLD RVGRGGGPAR ECLGEACSSS
260 270 280 290 300
GLPGPEPLEF QHPALAKFED HEVGWLPETQ PQGSMNLDSG SLKLGDAFRP
310 320 330 340 350
ASRSRSASGE VLGSWGGSGG TIPIVQAVPQ GAETPRPLFQ TKLSRFLPQK
360 370 380 390 400
EAAVMYPAEL PQSSPADSEQ RVSETCIVPA WLPSLPDEVF LEEAPLVRMR
410 420 430 440 450
SPPDPHASQG PPASVHASDQ PYGTGLGQRT GQVTVPTEYP LHECPGTAGA
460 470 480 490 500
DDCWQGVNGS VGISRPTSHT PTGTANDNIP TIDPTGLTTN PPTAAESDLL
510 520 530 540 550
KPVPADALGL SGNDTPGPSH NTALARGTGQ PGSRPTWPSQ CLEELVQELA
560 570 580 590 600
RLDPSLCDPL ASQPSPEPPL GLLDGLIPLA EVRAAMRPAC GEAGEEAAST
610 620 630 640 650
FEPGSYQFSF TQLLPAPREE TRLENPATHP VLDQPCGQGL PAPNNSIQGK
660 670 680 690 700
KVELAARLQK MLQDLHTEQE RLQGEAQAWA RRQAALEAAV RQACAPQELE
710 720 730 740 750
RFSRFMADLE RVLGLLLLLG SRLARVRRAL ARAASDSDPD EQASLLQRLR
760 770 780 790 800
LLQRQEEDAK ELKEHVARRE RAVREVLVRA LPVEELRVYC ALLAGKAAVL
810 820 830 840 850
AQQRNLDERI RLLQDQLDAI RDDLGHHAPS PSPARPPGTC PPVQPPFPLL
LT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NN40 | A6NN40_HUMAN | Protein Shroom1 | SHROOM1 | 783 | Annotation score: | ||
C9JXU1 | C9JXU1_HUMAN | Protein Shroom1 | SHROOM1 | 324 | Annotation score: |
Sequence cautioni
The sequence BAB85546 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 129 | A → V in AAM15526 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032061 | 180 | P → L. Corresponds to variant dbSNP:rs2292030Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024962 | 742 – 746 | Missing in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF314142 mRNA Translation: AAM15526.1 AB075840 mRNA Translation: BAB85546.1 Different initiation. AC004775 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62311.1 CH471062 Genomic DNA Translation: EAW62312.1 BC104914 mRNA Translation: AAI04915.1 BC104916 mRNA Translation: AAI04917.1 BC143494 mRNA Translation: AAI43495.1 |
CCDSi | CCDS4161.1 [Q2M3G4-2] CCDS54902.1 [Q2M3G4-1] |
RefSeqi | NP_001166171.1, NM_001172700.1 [Q2M3G4-1] NP_597713.2, NM_133456.2 [Q2M3G4-2] XP_005271942.1, XM_005271885.4 [Q2M3G4-1] XP_005271943.1, XM_005271886.3 [Q2M3G4-1] XP_011541469.1, XM_011543167.2 [Q2M3G4-1] |
Genome annotation databases
Ensembli | ENST00000319854; ENSP00000324245; ENSG00000164403 [Q2M3G4-2] ENST00000378679; ENSP00000367950; ENSG00000164403 [Q2M3G4-1] ENST00000617339; ENSP00000478436; ENSG00000164403 [Q2M3G4-1] |
GeneIDi | 134549 |
KEGGi | hsa:134549 |
UCSCi | uc003kxx.3, human [Q2M3G4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF314142 mRNA Translation: AAM15526.1 AB075840 mRNA Translation: BAB85546.1 Different initiation. AC004775 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62311.1 CH471062 Genomic DNA Translation: EAW62312.1 BC104914 mRNA Translation: AAI04915.1 BC104916 mRNA Translation: AAI04917.1 BC143494 mRNA Translation: AAI43495.1 |
CCDSi | CCDS4161.1 [Q2M3G4-2] CCDS54902.1 [Q2M3G4-1] |
RefSeqi | NP_001166171.1, NM_001172700.1 [Q2M3G4-1] NP_597713.2, NM_133456.2 [Q2M3G4-2] XP_005271942.1, XM_005271885.4 [Q2M3G4-1] XP_005271943.1, XM_005271886.3 [Q2M3G4-1] XP_011541469.1, XM_011543167.2 [Q2M3G4-1] |
3D structure databases
SMRi | Q2M3G4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126408, 8 interactors |
DIPi | DIP-42367N |
IntActi | Q2M3G4, 10 interactors |
MINTi | Q2M3G4 |
STRINGi | 9606.ENSP00000367950 |
PTM databases
iPTMneti | Q2M3G4 |
PhosphoSitePlusi | Q2M3G4 |
Genetic variation databases
BioMutai | SHROOM1 |
DMDMi | 121941488 |
Proteomic databases
EPDi | Q2M3G4 |
jPOSTi | Q2M3G4 |
MassIVEi | Q2M3G4 |
MaxQBi | Q2M3G4 |
PaxDbi | Q2M3G4 |
PeptideAtlasi | Q2M3G4 |
PRIDEi | Q2M3G4 |
ProteomicsDBi | 61376 [Q2M3G4-1] 61377 [Q2M3G4-2] |
Protocols and materials databases
Antibodypediai | 64246, 50 antibodies |
Genome annotation databases
Ensembli | ENST00000319854; ENSP00000324245; ENSG00000164403 [Q2M3G4-2] ENST00000378679; ENSP00000367950; ENSG00000164403 [Q2M3G4-1] ENST00000617339; ENSP00000478436; ENSG00000164403 [Q2M3G4-1] |
GeneIDi | 134549 |
KEGGi | hsa:134549 |
UCSCi | uc003kxx.3, human [Q2M3G4-1] |
Organism-specific databases
CTDi | 134549 |
DisGeNETi | 134549 |
GeneCardsi | SHROOM1 |
HGNCi | HGNC:24084, SHROOM1 |
HPAi | ENSG00000164403, Tissue enhanced (liver, urinary bladder) |
MIMi | 611179, gene |
neXtProti | NX_Q2M3G4 |
OpenTargetsi | ENSG00000164403 |
PharmGKBi | PA147357345 |
VEuPathDBi | HostDB:ENSG00000164403.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SM3B, Eukaryota |
GeneTreei | ENSGT00940000160656 |
InParanoidi | Q2M3G4 |
OMAi | VSRPTCC |
OrthoDBi | 729991at2759 |
PhylomeDBi | Q2M3G4 |
TreeFami | TF335754 |
Enzyme and pathway databases
PathwayCommonsi | Q2M3G4 |
Miscellaneous databases
BioGRID-ORCSi | 134549, 4 hits in 994 CRISPR screens |
ChiTaRSi | SHROOM1, human |
GenomeRNAii | 134549 |
Pharosi | Q2M3G4, Tdark |
PROi | PR:Q2M3G4 |
RNActi | Q2M3G4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164403, Expressed in urinary bladder and 210 other tissues |
ExpressionAtlasi | Q2M3G4, baseline and differential |
Genevisiblei | Q2M3G4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 2 hits |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHRM1_HUMAN | |
Accessioni | Q2M3G4Primary (citable) accession number: Q2M3G4 Secondary accession number(s): B7WP40 Q8TF41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | February 21, 2006 | |
Last modified: | April 7, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families