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UniProtKB - Q2M3G4 (SHRM1_HUMAN)

Entry version 120 (07 Apr 2021)
Sequence version 1 (21 Feb 2006)
Previous versions | rss
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Protein

Protein Shroom1

Gene

SHROOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the assembly of microtubule arrays during cell elongation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q2M3G4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom1
Alternative name(s):
Apical protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHROOM1
Synonyms:APXL2, KIAA1960
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24084, SHROOM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611179, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2M3G4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164403.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		134549

Open Targets

More...OpenTargetsi		ENSG00000164403

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA147357345

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q2M3G4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHROOM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		121941488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860611 – 852Protein Shroom1Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q2M3G4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2M3G4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q2M3G4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2M3G4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2M3G4

PeptideAtlas

More...PeptideAtlasi		Q2M3G4

PRoteomics IDEntifications database

More...PRIDEi		Q2M3G4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61376 [Q2M3G4-1]
61377 [Q2M3G4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2M3G4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2M3G4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164403, Expressed in urinary bladder and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q2M3G4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2M3G4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164403, Tissue enhanced (liver, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126408, 8 interactors

Database of interacting proteins

More...DIPi		DIP-42367N

Protein interaction database and analysis system

More...IntActi		Q2M3G4, 10 interactors

Molecular INTeraction database

More...MINTi		Q2M3G4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367950

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2M3G4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2M3G4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 233ASD1PROSITE-ProRule annotationAdd BLAST89
Domaini543 – 825ASD2PROSITE-ProRule annotationAdd BLAST283

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi713 – 719Poly-Leu7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SM3B, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160656

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2M3G4

Identification of Orthologs from Complete Genome Data

More...OMAi		VSRPTCC

Database of Orthologous Groups

More...OrthoDBi		729991at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2M3G4

TreeFam database of animal gene trees

More...TreeFami		TF335754

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR027685, Shroom_fam

The PANTHER Classification System

More...PANTHERi		PTHR15012, PTHR15012, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2M3G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALGPGGDR ASPASSTSSL DLWHLSMRAD SAYSSFSAAS GGPEPRTQSP 
        60         70         80         90        100
GTDLLPYLDW DYVRVVWGGP GPAPPDAALC TSPRPRPAVA ARSGPQPTEV 
       110        120        130        140        150
PGTPGPLNRQ ATPLLYALAA EAEAAAQAAE PPSPPASRAA YRQRLQGAQR 
       160        170        180        190        200
RVLRETSFQR KELRMSLPAR LRPTVPARPP ATHPRSASLS HPGGEGEPAR 
       210        220        230        240        250
SRAPAPGTAG RGPLANQQRK WCFSEPGKLD RVGRGGGPAR ECLGEACSSS 
       260        270        280        290        300
GLPGPEPLEF QHPALAKFED HEVGWLPETQ PQGSMNLDSG SLKLGDAFRP 
       310        320        330        340        350
ASRSRSASGE VLGSWGGSGG TIPIVQAVPQ GAETPRPLFQ TKLSRFLPQK 
       360        370        380        390        400
EAAVMYPAEL PQSSPADSEQ RVSETCIVPA WLPSLPDEVF LEEAPLVRMR 
       410        420        430        440        450
SPPDPHASQG PPASVHASDQ PYGTGLGQRT GQVTVPTEYP LHECPGTAGA 
       460        470        480        490        500
DDCWQGVNGS VGISRPTSHT PTGTANDNIP TIDPTGLTTN PPTAAESDLL 
       510        520        530        540        550
KPVPADALGL SGNDTPGPSH NTALARGTGQ PGSRPTWPSQ CLEELVQELA 
       560        570        580        590        600
RLDPSLCDPL ASQPSPEPPL GLLDGLIPLA EVRAAMRPAC GEAGEEAAST 
       610        620        630        640        650
FEPGSYQFSF TQLLPAPREE TRLENPATHP VLDQPCGQGL PAPNNSIQGK 
       660        670        680        690        700
KVELAARLQK MLQDLHTEQE RLQGEAQAWA RRQAALEAAV RQACAPQELE 
       710        720        730        740        750
RFSRFMADLE RVLGLLLLLG SRLARVRRAL ARAASDSDPD EQASLLQRLR 
       760        770        780        790        800
LLQRQEEDAK ELKEHVARRE RAVREVLVRA LPVEELRVYC ALLAGKAAVL 
       810        820        830        840        850
AQQRNLDERI RLLQDQLDAI RDDLGHHAPS PSPARPPGTC PPVQPPFPLL 

LT
Length:852
Mass (Da):90,786
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43DFAF54E8355877
GO
Isoform 2 (identifier: Q2M3G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     742-746: Missing.

Show »
Length:847
Mass (Da):90,274
Checksum:iB41E6BB4B11EF6D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NN40A6NN40_HUMAN
Protein Shroom1
SHROOM1
783Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXU1C9JXU1_HUMAN
Protein Shroom1
SHROOM1
324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85546 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129A → V in AAM15526 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032061180P → L. Corresponds to variant dbSNP:rs2292030Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024962742 – 746Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF314142 mRNA Translation: AAM15526.1
AB075840 mRNA Translation: BAB85546.1 Different initiation.
AC004775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62311.1
CH471062 Genomic DNA Translation: EAW62312.1
BC104914 mRNA Translation: AAI04915.1
BC104916 mRNA Translation: AAI04917.1
BC143494 mRNA Translation: AAI43495.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4161.1 [Q2M3G4-2]
CCDS54902.1 [Q2M3G4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001166171.1, NM_001172700.1 [Q2M3G4-1]
NP_597713.2, NM_133456.2 [Q2M3G4-2]
XP_005271942.1, XM_005271885.4 [Q2M3G4-1]
XP_005271943.1, XM_005271886.3 [Q2M3G4-1]
XP_011541469.1, XM_011543167.2 [Q2M3G4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319854; ENSP00000324245; ENSG00000164403 [Q2M3G4-2]
ENST00000378679; ENSP00000367950; ENSG00000164403 [Q2M3G4-1]
ENST00000617339; ENSP00000478436; ENSG00000164403 [Q2M3G4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		134549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:134549

UCSC genome browser

More...UCSCi		uc003kxx.3, human [Q2M3G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314142 mRNA Translation: AAM15526.1
AB075840 mRNA Translation: BAB85546.1 Different initiation.
AC004775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62311.1
CH471062 Genomic DNA Translation: EAW62312.1
BC104914 mRNA Translation: AAI04915.1
BC104916 mRNA Translation: AAI04917.1
BC143494 mRNA Translation: AAI43495.1
CCDSiCCDS4161.1 [Q2M3G4-2]
CCDS54902.1 [Q2M3G4-1]
RefSeqiNP_001166171.1, NM_001172700.1 [Q2M3G4-1]
NP_597713.2, NM_133456.2 [Q2M3G4-2]
XP_005271942.1, XM_005271885.4 [Q2M3G4-1]
XP_005271943.1, XM_005271886.3 [Q2M3G4-1]
XP_011541469.1, XM_011543167.2 [Q2M3G4-1]

3D structure databases

SMRiQ2M3G4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126408, 8 interactors
DIPiDIP-42367N
IntActiQ2M3G4, 10 interactors
MINTiQ2M3G4
STRINGi9606.ENSP00000367950

PTM databases

iPTMnetiQ2M3G4
PhosphoSitePlusiQ2M3G4

Genetic variation databases

BioMutaiSHROOM1
DMDMi121941488

Proteomic databases

EPDiQ2M3G4
jPOSTiQ2M3G4
MassIVEiQ2M3G4
MaxQBiQ2M3G4
PaxDbiQ2M3G4
PeptideAtlasiQ2M3G4
PRIDEiQ2M3G4
ProteomicsDBi61376 [Q2M3G4-1]
61377 [Q2M3G4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		64246, 50 antibodies

Genome annotation databases

EnsembliENST00000319854; ENSP00000324245; ENSG00000164403 [Q2M3G4-2]
ENST00000378679; ENSP00000367950; ENSG00000164403 [Q2M3G4-1]
ENST00000617339; ENSP00000478436; ENSG00000164403 [Q2M3G4-1]
GeneIDi134549
KEGGihsa:134549
UCSCiuc003kxx.3, human [Q2M3G4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		134549
DisGeNETi134549

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHROOM1
HGNCiHGNC:24084, SHROOM1
HPAiENSG00000164403, Tissue enhanced (liver, urinary bladder)
MIMi611179, gene
neXtProtiNX_Q2M3G4
OpenTargetsiENSG00000164403
PharmGKBiPA147357345
VEuPathDBiHostDB:ENSG00000164403.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SM3B, Eukaryota
GeneTreeiENSGT00940000160656
InParanoidiQ2M3G4
OMAiVSRPTCC
OrthoDBi729991at2759
PhylomeDBiQ2M3G4
TreeFamiTF335754

Enzyme and pathway databases

PathwayCommonsiQ2M3G4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		134549, 4 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHROOM1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		134549
PharosiQ2M3G4, Tdark

Protein Ontology

More...PROi		PR:Q2M3G4
RNActiQ2M3G4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164403, Expressed in urinary bladder and 210 other tissues
ExpressionAtlasiQ2M3G4, baseline and differential
GenevisibleiQ2M3G4, HS

Family and domain databases

InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 2 hits
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M3G4
Secondary accession number(s): B7WP40
, B7ZL01, Q8TDP0, Q8TF41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 21, 2006
Last modified: April 7, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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