UniProtKB - Q2M3G0 (ABCB5_HUMAN)
ATP-binding cassette sub-family B member 5
ABCB5
Functioni
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344).
Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
By similarity4 PublicationsMiscellaneous
Caution
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 421 – 428 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1050 – 1057 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: UniProtKB-EC
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- efflux transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- eye development Source: UniProtKB
- regulation of membrane potential Source: UniProtKB
- transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Differentiation, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 7.6.2.2, 2681 |
PathwayCommonsi | Q2M3G0 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport |
SignaLinki | Q2M3G0 |
Protein family/group databases
TCDBi | 3.A.1.201.13, the atp-binding cassette (abc) superfamily 3.A.1.209.4, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family B member 5CuratedAlternative name(s): ABCB5 P-gp P-glycoprotein ABCB5 (EC:7.6.2.21 Publication) |
Gene namesi | Name:ABCB5Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:46, ABCB5 |
MIMi | 611785, gene |
neXtProti | NX_Q2M3G0 |
VEuPathDBi | HostDB:ENSG00000004846 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 49 – 69 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 181 – 201 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 294 – 314 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 322 – 342 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 693 – 713 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 737 – 757 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 827 – 847 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 917 – 937 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 954 – 974 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 340273 |
OpenTargetsi | ENSG00000004846 |
PharmGKBi | PA24387 |
Miscellaneous databases
Pharosi | Q2M3G0, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1772928 |
DrugBanki | DB06263, Amrubicin DB13997, Baloxavir marboxil DB11591, Bilastine DB04851, Biricodar DB08870, Brentuximab vedotin DB12267, Brigatinib DB09183, Dasabuvir DB11943, Delafloxacin DB14067, Dofequidar DB00254, Doxycycline DB12010, Fostamatinib DB00598, Labetalol DB04948, Lofexidine DB11691, Naldemedine DB11641, Vinflunine |
Genetic variation databases
BioMutai | ABCB5 |
DMDMi | 308153645 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253575 | 1 – 1257 | ATP-binding cassette sub-family B member 5Add BLAST | 1257 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 423 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 789 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 819 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 910 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q2M3G0 |
jPOSTi | Q2M3G0 |
MassIVEi | Q2M3G0 |
MaxQBi | Q2M3G0 |
PaxDbi | Q2M3G0 |
PeptideAtlasi | Q2M3G0 |
PRIDEi | Q2M3G0 |
ProteomicsDBi | 61374 [Q2M3G0-4] 61375 [Q2M3G0-2] 6148 |
PTM databases
GlyGeni | Q2M3G0, 11 sites |
iPTMneti | Q2M3G0 |
PhosphoSitePlusi | Q2M3G0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000004846, Expressed in cauda epididymis and 79 other tissues |
ExpressionAtlasi | Q2M3G0, baseline and differential |
Genevisiblei | Q2M3G0, HS |
Organism-specific databases
HPAi | ENSG00000004846, Tissue enriched (epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131028, 11 interactors |
IntActi | Q2M3G0, 2 interactors |
STRINGi | 9606.ENSP00000384881 |
Miscellaneous databases
RNActi | Q2M3G0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 350 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 302 | |
Domaini | 386 – 622 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 693 – 980 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 288 | |
Domaini | 1015 – 1253 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000161340 |
HOGENOMi | CLU_000604_1_9_1 |
InParanoidi | Q2M3G0 |
OMAi | FGYMQIS |
OrthoDBi | 186078at2759 |
PhylomeDBi | Q2M3G0 |
TreeFami | TF105193 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENSERAEEM QENYQRNGTA EEQPKLRKEA VGSIEIFRFA DGLDITLMIL
60 70 80 90 100
GILASLVNGA CLPLMPLVLG EMSDNLISGC LVQTNTTNYQ NCTQSQEKLN
110 120 130 140 150
EDMTLLTLYY VGIGVAALIF GYIQISLWII TAARQTKRIR KQFFHSVLAQ
160 170 180 190 200
DIGWFDSCDI GELNTRMTDD IDKISDGIGD KIALLFQNMS TFSIGLAVGL
210 220 230 240 250
VKGWKLTLVT LSTSPLIMAS AAACSRMVIS LTSKELSAYS KAGAVAEEVL
260 270 280 290 300
SSIRTVIAFR AQEKELQRYT QNLKDAKDFG IKRTIASKVS LGAVYFFMNG
310 320 330 340 350
TYGLAFWYGT SLILNGEPGY TIGTVLAVFF SVIHSSYCIG AAVPHFETFA
360 370 380 390 400
IARGAAFHIF QVIDKKPSID NFSTAGYKPE SIEGTVEFKN VSFNYPSRPS
410 420 430 440 450
IKILKGLNLR IKSGETVALV GLNGSGKSTV VQLLQRLYDP DDGFIMVDEN
460 470 480 490 500
DIRALNVRHY RDHIGVVSQE PVLFGTTISN NIKYGRDDVT DEEMERAARE
510 520 530 540 550
ANAYDFIMEF PNKFNTLVGE KGAQMSGGQK QRIAIARALV RNPKILILDE
560 570 580 590 600
ATSALDSESK SAVQAALEKA SKGRTTIVVA HRLSTIRSAD LIVTLKDGML
610 620 630 640 650
AEKGAHAELM AKRGLYYSLV MSQDIKKADE QMESMTYSTE RKTNSLPLHS
660 670 680 690 700
VKSIKSDFID KAEESTQSKE ISLPEVSLLK ILKLNKPEWP FVVLGTLASV
710 720 730 740 750
LNGTVHPVFS IIFAKIITMF GNNDKTTLKH DAEIYSMIFV ILGVICFVSY
760 770 780 790 800
FMQGLFYGRA GEILTMRLRH LAFKAMLYQD IAWFDEKENS TGGLTTILAI
810 820 830 840 850
DIAQIQGATG SRIGVLTQNA TNMGLSVIIS FIYGWEMTFL ILSIAPVLAV
860 870 880 890 900
TGMIETAAMT GFANKDKQEL KHAGKIATEA LENIRTIVSL TREKAFEQMY
910 920 930 940 950
EEMLQTQHRN TSKKAQIIGS CYAFSHAFIY FAYAAGFRFG AYLIQAGRMT
960 970 980 990 1000
PEGMFIVFTA IAYGAMAIGE TLVLAPEYSK AKSGAAHLFA LLEKKPNIDS
1010 1020 1030 1040 1050
RSQEGKKPDT CEGNLEFREV SFFYPCRPDV FILRGLSLSI ERGKTVAFVG
1060 1070 1080 1090 1100
SSGCGKSTSV QLLQRLYDPV QGQVLFDGVD AKELNVQWLR SQIAIVPQEP
1110 1120 1130 1140 1150
VLFNCSIAEN IAYGDNSRVV PLDEIKEAAN AANIHSFIEG LPEKYNTQVG
1160 1170 1180 1190 1200
LKGAQLSGGQ KQRLAIARAL LQKPKILLLD EATSALDNDS EKVVQHALDK
1210 1220 1230 1240 1250
ARTGRTCLVV THRLSAIQNA DLIVVLHNGK IKEQGTHQEL LRNRDIYFKL
VNAQSVQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C165 | H7C165_HUMAN | ATP-binding cassette sub-family B m... | ABCB5 | 314 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 577 | I → M in AAN76500 (PubMed:12960149).Curated | 1 | |
Sequence conflicti | 1141 | L → P in AAW31630 (PubMed:15760339).Curated | 1 | |
Sequence conflicti | 1186 | L → I in ADV32637 (PubMed:21652540).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028387 | 560 | K → E1 PublicationCorresponds to variant dbSNP:rs2301641Ensembl. | 1 | |
Natural variantiVAR_028388 | 669 | K → R. Corresponds to variant dbSNP:rs13222448Ensembl. | 1 | |
Natural variantiVAR_035731 | 675 | E → V in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_062662 | 880 | A → T in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1187237313Ensembl. | 1 | |
Natural variantiVAR_033456 | 905 | Q → H. Corresponds to variant dbSNP:rs35885925EnsemblClinVar. | 1 | |
Natural variantiVAR_028389 | 915 | A → T. Corresponds to variant dbSNP:rs17143304Ensembl. | 1 | |
Natural variantiVAR_028390 | 970 | E → K5 PublicationsCorresponds to variant dbSNP:rs6461515Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056752 | 1 – 445 | Missing in isoform 1, isoform 2 and isoform 3. 4 PublicationsAdd BLAST | 445 | |
Alternative sequenceiVSP_056753 | 570 – 576 | ASKGRTT → DTPRYSF in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_056754 | 570 – 571 | AS → KK in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_056755 | 572 – 1257 | Missing in isoform 3. 1 PublicationAdd BLAST | 686 | |
Alternative sequenceiVSP_056756 | 577 – 1257 | Missing in isoform 2. 1 PublicationAdd BLAST | 681 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF319622 mRNA Translation: AAN76500.1 Different initiation. AF399931 mRNA Translation: AAQ03033.1 Different initiation. AY090613 mRNA Translation: AAM09027.1 AY234788 mRNA Translation: AAO73470.1 AY851364 mRNA Translation: AAW31629.1 AY851365 mRNA Translation: AAW31630.1 GU437216 mRNA Translation: ADV32636.1 GU437217 mRNA Translation: ADV32637.1 AB353947 mRNA Translation: BAF75364.1 AY230001 mRNA Translation: AAP55848.1 AC002486 Genomic DNA No translation available. AC005060 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24273.1 CH471073 Genomic DNA Translation: EAW93726.1 BC104894 mRNA Translation: AAI04895.2 BC104920 mRNA Translation: AAI04921.1 BC110370 mRNA No translation available. |
CCDSi | CCDS5371.1 [Q2M3G0-1] CCDS55090.1 [Q2M3G0-4] CCDS55091.1 [Q2M3G0-2] CCDS55092.1 [Q2M3G0-3] |
RefSeqi | NP_001157413.1, NM_001163941.1 [Q2M3G0-4] NP_001157414.1, NM_001163942.1 [Q2M3G0-2] NP_001157465.1, NM_001163993.2 [Q2M3G0-3] NP_848654.3, NM_178559.5 [Q2M3G0-1] XP_011513669.1, XM_011515367.2 [Q2M3G0-1] |
Genome annotation databases
Ensembli | ENST00000258738; ENSP00000258738; ENSG00000004846 [Q2M3G0-1] ENST00000404938; ENSP00000384881; ENSG00000004846 ENST00000406935; ENSP00000383899; ENSG00000004846 [Q2M3G0-3] ENST00000443026; ENSP00000406730; ENSG00000004846 [Q2M3G0-2] |
GeneIDi | 340273 |
KEGGi | hsa:340273 |
MANE-Selecti | ENST00000404938.7; ENSP00000384881.2; NM_001163941.2; NP_001157413.1 |
UCSCi | uc003suv.4, human [Q2M3G0-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF319622 mRNA Translation: AAN76500.1 Different initiation. AF399931 mRNA Translation: AAQ03033.1 Different initiation. AY090613 mRNA Translation: AAM09027.1 AY234788 mRNA Translation: AAO73470.1 AY851364 mRNA Translation: AAW31629.1 AY851365 mRNA Translation: AAW31630.1 GU437216 mRNA Translation: ADV32636.1 GU437217 mRNA Translation: ADV32637.1 AB353947 mRNA Translation: BAF75364.1 AY230001 mRNA Translation: AAP55848.1 AC002486 Genomic DNA No translation available. AC005060 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24273.1 CH471073 Genomic DNA Translation: EAW93726.1 BC104894 mRNA Translation: AAI04895.2 BC104920 mRNA Translation: AAI04921.1 BC110370 mRNA No translation available. |
CCDSi | CCDS5371.1 [Q2M3G0-1] CCDS55090.1 [Q2M3G0-4] CCDS55091.1 [Q2M3G0-2] CCDS55092.1 [Q2M3G0-3] |
RefSeqi | NP_001157413.1, NM_001163941.1 [Q2M3G0-4] NP_001157414.1, NM_001163942.1 [Q2M3G0-2] NP_001157465.1, NM_001163993.2 [Q2M3G0-3] NP_848654.3, NM_178559.5 [Q2M3G0-1] XP_011513669.1, XM_011515367.2 [Q2M3G0-1] |
3D structure databases
SMRi | Q2M3G0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131028, 11 interactors |
IntActi | Q2M3G0, 2 interactors |
STRINGi | 9606.ENSP00000384881 |
Chemistry databases
ChEMBLi | CHEMBL1772928 |
DrugBanki | DB06263, Amrubicin DB13997, Baloxavir marboxil DB11591, Bilastine DB04851, Biricodar DB08870, Brentuximab vedotin DB12267, Brigatinib DB09183, Dasabuvir DB11943, Delafloxacin DB14067, Dofequidar DB00254, Doxycycline DB12010, Fostamatinib DB00598, Labetalol DB04948, Lofexidine DB11691, Naldemedine DB11641, Vinflunine |
Protein family/group databases
TCDBi | 3.A.1.201.13, the atp-binding cassette (abc) superfamily 3.A.1.209.4, the atp-binding cassette (abc) superfamily |
PTM databases
GlyGeni | Q2M3G0, 11 sites |
iPTMneti | Q2M3G0 |
PhosphoSitePlusi | Q2M3G0 |
Genetic variation databases
BioMutai | ABCB5 |
DMDMi | 308153645 |
Proteomic databases
EPDi | Q2M3G0 |
jPOSTi | Q2M3G0 |
MassIVEi | Q2M3G0 |
MaxQBi | Q2M3G0 |
PaxDbi | Q2M3G0 |
PeptideAtlasi | Q2M3G0 |
PRIDEi | Q2M3G0 |
ProteomicsDBi | 61374 [Q2M3G0-4] 61375 [Q2M3G0-2] 6148 |
Protocols and materials databases
Antibodypediai | 11940, 420 antibodies from 37 providers |
DNASUi | 340273 |
Genome annotation databases
Ensembli | ENST00000258738; ENSP00000258738; ENSG00000004846 [Q2M3G0-1] ENST00000404938; ENSP00000384881; ENSG00000004846 ENST00000406935; ENSP00000383899; ENSG00000004846 [Q2M3G0-3] ENST00000443026; ENSP00000406730; ENSG00000004846 [Q2M3G0-2] |
GeneIDi | 340273 |
KEGGi | hsa:340273 |
MANE-Selecti | ENST00000404938.7; ENSP00000384881.2; NM_001163941.2; NP_001157413.1 |
UCSCi | uc003suv.4, human [Q2M3G0-4] |
Organism-specific databases
CTDi | 340273 |
DisGeNETi | 340273 |
GeneCardsi | ABCB5 |
HGNCi | HGNC:46, ABCB5 |
HPAi | ENSG00000004846, Tissue enriched (epididymis) |
MIMi | 611785, gene |
neXtProti | NX_Q2M3G0 |
OpenTargetsi | ENSG00000004846 |
PharmGKBi | PA24387 |
VEuPathDBi | HostDB:ENSG00000004846 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000161340 |
HOGENOMi | CLU_000604_1_9_1 |
InParanoidi | Q2M3G0 |
OMAi | FGYMQIS |
OrthoDBi | 186078at2759 |
PhylomeDBi | Q2M3G0 |
TreeFami | TF105193 |
Enzyme and pathway databases
BRENDAi | 7.6.2.2, 2681 |
PathwayCommonsi | Q2M3G0 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport |
SignaLinki | Q2M3G0 |
Miscellaneous databases
BioGRID-ORCSi | 340273, 10 hits in 1033 CRISPR screens |
ChiTaRSi | ABCB5, human |
GeneWikii | ABCB5 |
GenomeRNAii | 340273 |
Pharosi | Q2M3G0, Tbio |
PROi | PR:Q2M3G0 |
RNActi | Q2M3G0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000004846, Expressed in cauda epididymis and 79 other tissues |
ExpressionAtlasi | Q2M3G0, baseline and differential |
Genevisiblei | Q2M3G0, HS |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCB5_HUMAN | |
Accessioni | Q2M3G0Primary (citable) accession number: Q2M3G0 Secondary accession number(s): A4D131 Q8IXA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 1, 2014 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families