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Entry version 110 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

WASH complex subunit 4

Gene

WASHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.1 Publication2 Publications

Caution

One study reported a nucleation-promoting factor (NPF) activity towards the Arp2/3 complex using partially purified samples of the WASH complex (PubMed:19922875). In another study, the in vitro reconstituted and purified recombinant WASH core complex, consisting of WASHC3, WASHC4, WASHC5, WASHC1 and the N-terminal residues 1-356 of WASHC2, did not show activity toward Arp2/3 complex (PubMed:20498093).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q2M389

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.3.1.2, the sorting nexin27 (snx27)-retromer assembly apparatus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WASH complex subunit 4Imported
Alternative name(s):
Strumpellin and WASH-interacting protein1 Publication
Short name:
SWIP1 Publication
WASH complex subunit SWIPCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WASHC4Imported
Synonyms:KIAA1033Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136051.13

Human Gene Nomenclature Database

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HGNCi
HGNC:29174, WASHC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615748, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M389

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 43 (MRT43)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0713841019P → R in MRT43; reduced expression of the protein; alters the WASH complex. 1 PublicationCorresponds to variant dbSNP:rs587777411EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23325

MalaCards human disease database

More...
MalaCardsi
WASHC4
MIMi615817, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136051

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616, Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394626

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2M389, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WASHC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452861

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002825752 – 1173WASH complex subunit 4Add BLAST1172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei1154PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2M389

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q2M389

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q2M389

MaxQB - The MaxQuant DataBase

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MaxQBi
Q2M389

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2M389

PeptideAtlas

More...
PeptideAtlasi
Q2M389

PRoteomics IDEntifications database

More...
PRIDEi
Q2M389

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61366 [Q2M389-1]
61367 [Q2M389-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M389

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M389

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136051, Expressed in oviduct epithelium and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q2M389, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q2M389, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136051, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex.

1 Publication2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116913, 44 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1163, WASH complex, variant WASHC1/WASHC2C
CPX-1168, WASH complex, variant WASH2P/WASHC2C
CPX-1169, WASH complex, variant WASH3P/WASHC2C
CPX-1170, WASH complex, variant WASH4P/WASHC2C
CPX-1171, WASH complex, variant WASH6P/WASHC2C
CPX-1172, WASH complex, variant WASHC1/WASHC2A
CPX-1173, WASH complex, variant WASH2P/WASHC2A
CPX-1174, WASH complex, variant WASH3P/WASHC2A
CPX-1175, WASH complex, variant WASH4P/WASHC2A
CPX-1176, WASH complex, variant WASH6P/WASHC2A

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q2M389

Protein interaction database and analysis system

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IntActi
Q2M389, 20 interactors

Molecular INTeraction database

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MINTi
Q2M389

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2M389, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q2M389

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni705 – 1173Sufficient for interaction with WASHC51 PublicationAdd BLAST469

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1135 – 1161Sequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SWIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3578, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002524

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2M389

KEGG Orthology (KO)

More...
KOi
K18465

Database of Orthologous Groups

More...
OrthoDBi
186054at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2M389

TreeFam database of animal gene trees

More...
TreeFami
TF324604

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028283, WASH-7_C
IPR028282, WASH-7_central
IPR028191, WASH-7_N
IPR027307, WASH7

The PANTHER Classification System

More...
PANTHERi
PTHR31409, PTHR31409, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14746, WASH-7_C, 1 hit
PF14744, WASH-7_mid, 1 hit
PF14745, WASH-7_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2M389-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVETLSPDW EFDRVDDGSQ KIHAEVQLKN YGKFLEEYTS QLRRIEDALD
60 70 80 90 100
DSIGDVWDFN LDPIALKLLP YEQSSLLELI KTENKVLNKV ITVYAALCCE
110 120 130 140 150
IKKLKYEAET KFYNGLLFYG EGATDASMVE GDCQIQMGRF ISFLQELSCF
160 170 180 190 200
VTRCYEVVMN VVHQLAALYI SNKIAPKIIE TTGVHFQTMY EHLGELLTVL
210 220 230 240 250
LTLDEIIDNH ITLKDHWTMY KRLLKSVHHN PSKFGIQEEK LKPFEKFLLK
260 270 280 290 300
LEGQLLDGMI FQACIEQQFD SLNGGVSVSK NSTFAEEFAH SIRSIFANVE
310 320 330 340 350
AKLGEPSEID QRDKYVGICG LFVLHFQIFR TIDKKFYKSL LDICKKVPAI
360 370 380 390 400
TLTANIIWFP DNFLIQKIPA AAKLLDRKSL QAIKIHRDTF LQQKAQSLTK
410 420 430 440 450
DVQSYYVFVS SWMMKMESIL SKEQRMDKFA EDLTNRCNVF IQGFLYAYSI
460 470 480 490 500
STIIKTTMNL YMSMQKPMTK TSVKALCRLV ELLKAIEHMF YRRSMVVADS
510 520 530 540 550
VSHITQHLQH QALHSISVAK KRVISDKKYS EQRLDVLSAL VLAENTLNGP
560 570 580 590 600
STKQRRLIVS LALSVGTQMK TFKDEELFPL QVVMKKLDLI SELRERVQTQ
610 620 630 640 650
CDCCFLYWHR AVFPIYLDDV YENAVDAARL HYMFSALRDC VPAMMHARHL
660 670 680 690 700
ESYEILLDCY DKEIMEILNE HLLDKLCKEI EKDLRLSVHT HLKLDDRNPF
710 720 730 740 750
KVGMKDLALF FSLNPIRFFN RFIDIRAYVT HYLDKTFYNL TTVALHDWAT
760 770 780 790 800
YSEMRNLATQ RYGLVMTEAH LPSQTLEQGL DVLEIMRNIH IFVSRYLYNL
810 820 830 840 850
NNQIFIERTS NNKHLNTINI RHIANSIRTH GTGIMNTTVN FTYQFLKKKF
860 870 880 890 900
YIFSQFMYDE HIKSRLIKDI RFFREIKDQN DHKYPFDRAE KFNRGIRKLG
910 920 930 940 950
VTPEGQSYLD QFRQLISQIG NAMGYVRMIR SGGLHCSSNA IRFVPDLEDI
960 970 980 990 1000
VNFEELVKEE GLAEETLKAA RHLDSVLSDH TRNSAEGTEY FKMLVDVFAP
1010 1020 1030 1040 1050
EFRRPKNIHL RNFYIIVPPL TLNFVEHSIS CKEKLNKKNK IGAAFTDDGF
1060 1070 1080 1090 1100
AMGVAYILKL LDQYREFDSL HWFQSVREKY LKEIRAVAKQ QNVQSASQDE
1110 1120 1130 1140 1150
KLLQTMNLTQ KRLDVYLQEF ELLYFSLSSA RIFFRADKTA AEENQEKKEK
1160 1170
EEETKTSNGD LSDSTVSADP VVK
Length:1,173
Mass (Da):136,403
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD073D5F21127DED
GO
Isoform 2 (identifier: Q2M389-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-851: VNFTYQFLKKKFY → KWAFTAWRGGPRL
     852-1173: Missing.

Show »
Length:851
Mass (Da):98,765
Checksum:iD68E00F5406CC64D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X256A0A087X256_HUMAN
WASH complex subunit 4
WASHC4
1,174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYH7F8VYH7_HUMAN
WASH complex subunit 4
WASHC4
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNZ5F8VNZ5_HUMAN
WASH complex subunit 4
WASHC4
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1W1F8W1W1_HUMAN
WASH complex subunit 4
WASHC4
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMM5R4GMM5_HUMAN
WASH complex subunit 4
WASHC4
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQX3F8VQX3_HUMAN
WASH complex subunit 4
WASHC4
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10851 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA82985 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293R → Q in BAA91816 (PubMed:14702039).Curated1
Sequence conflicti608W → R in BAA91816 (PubMed:14702039).Curated1
Sequence conflicti759T → A in BAA91816 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031417323V → L. Corresponds to variant dbSNP:rs34434425Ensembl.1
Natural variantiVAR_057825599T → S. Corresponds to variant dbSNP:rs1345092Ensembl.1
Natural variantiVAR_031418901V → ICombined sources2 PublicationsCorresponds to variant dbSNP:rs1663564Ensembl.1
Natural variantiVAR_0713841019P → R in MRT43; reduced expression of the protein; alters the WASH complex. 1 PublicationCorresponds to variant dbSNP:rs587777411EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024208839 – 851VNFTY…KKKFY → KWAFTAWRGGPRL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_024209852 – 1173Missing in isoform 2. 1 PublicationAdd BLAST322

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB028956 mRNA Translation: BAA82985.1 Different initiation.
AK001657 mRNA Translation: BAA91816.1
BC031358 mRNA Translation: AAH31358.1
AC016257 Genomic DNA No translation available.
BC040936 mRNA Translation: AAH40936.1
BC104992 mRNA Translation: AAI04993.1
BC104994 mRNA Translation: AAI04995.1
BC110850 mRNA Translation: AAI10851.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS41826.1 [Q2M389-1]

NCBI Reference Sequences

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RefSeqi
NP_001280569.1, NM_001293640.1
NP_056090.1, NM_015275.2 [Q2M389-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000332180; ENSP00000328062; ENSG00000136051 [Q2M389-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23325

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23325

UCSC genome browser

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UCSCi
uc001tld.4, human [Q2M389-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028956 mRNA Translation: BAA82985.1 Different initiation.
AK001657 mRNA Translation: BAA91816.1
BC031358 mRNA Translation: AAH31358.1
AC016257 Genomic DNA No translation available.
BC040936 mRNA Translation: AAH40936.1
BC104992 mRNA Translation: AAI04993.1
BC104994 mRNA Translation: AAI04995.1
BC110850 mRNA Translation: AAI10851.1 Sequence problems.
CCDSiCCDS41826.1 [Q2M389-1]
RefSeqiNP_001280569.1, NM_001293640.1
NP_056090.1, NM_015275.2 [Q2M389-1]

3D structure databases

SMRiQ2M389
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116913, 44 interactors
ComplexPortaliCPX-1163, WASH complex, variant WASHC1/WASHC2C
CPX-1168, WASH complex, variant WASH2P/WASHC2C
CPX-1169, WASH complex, variant WASH3P/WASHC2C
CPX-1170, WASH complex, variant WASH4P/WASHC2C
CPX-1171, WASH complex, variant WASH6P/WASHC2C
CPX-1172, WASH complex, variant WASHC1/WASHC2A
CPX-1173, WASH complex, variant WASH2P/WASHC2A
CPX-1174, WASH complex, variant WASH3P/WASHC2A
CPX-1175, WASH complex, variant WASH4P/WASHC2A
CPX-1176, WASH complex, variant WASH6P/WASHC2A
CORUMiQ2M389
IntActiQ2M389, 20 interactors
MINTiQ2M389
STRINGi9606.ENSP00000484713

Protein family/group databases

TCDBi9.A.3.1.2, the sorting nexin27 (snx27)-retromer assembly apparatus

PTM databases

iPTMnetiQ2M389
PhosphoSitePlusiQ2M389

Polymorphism and mutation databases

BioMutaiWASHC4
DMDMi296452861

Proteomic databases

EPDiQ2M389
jPOSTiQ2M389
MassIVEiQ2M389
MaxQBiQ2M389
PaxDbiQ2M389
PeptideAtlasiQ2M389
PRIDEiQ2M389
ProteomicsDBi61366 [Q2M389-1]
61367 [Q2M389-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56699, 33 antibodies

Genome annotation databases

EnsembliENST00000332180; ENSP00000328062; ENSG00000136051 [Q2M389-1]
GeneIDi23325
KEGGihsa:23325
UCSCiuc001tld.4, human [Q2M389-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23325
DisGeNETi23325
EuPathDBiHostDB:ENSG00000136051.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WASHC4
HGNCiHGNC:29174, WASHC4
HPAiENSG00000136051, Low tissue specificity
MalaCardsiWASHC4
MIMi615748, gene
615817, phenotype
neXtProtiNX_Q2M389
OpenTargetsiENSG00000136051
Orphaneti88616, Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA128394626

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3578, Eukaryota
GeneTreeiENSGT00390000002524
InParanoidiQ2M389
KOiK18465
OrthoDBi186054at2759
PhylomeDBiQ2M389
TreeFamiTF324604

Enzyme and pathway databases

PathwayCommonsiQ2M389

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23325, 24 hits in 853 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA1033, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23325
PharosiQ2M389, Tbio

Protein Ontology

More...
PROi
PR:Q2M389
RNActiQ2M389, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136051, Expressed in oviduct epithelium and 248 other tissues
ExpressionAtlasiQ2M389, baseline and differential
GenevisibleiQ2M389, HS

Family and domain databases

InterProiView protein in InterPro
IPR028283, WASH-7_C
IPR028282, WASH-7_central
IPR028191, WASH-7_N
IPR027307, WASH7
PANTHERiPTHR31409, PTHR31409, 1 hit
PfamiView protein in Pfam
PF14746, WASH-7_C, 1 hit
PF14744, WASH-7_mid, 1 hit
PF14745, WASH-7_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWASC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M389
Secondary accession number(s): Q2NL83
, Q8IW61, Q8N5W7, Q9NVD6, Q9UPW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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