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Protein

Essential MCU regulator, mitochondrial

Gene

SMDT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling.By similarity

GO - Biological processi

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-BTA-8949215 Mitochondrial calcium ion transport
R-BTA-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Essential MCU regulator, mitochondrialBy similarity
Alternative name(s):
Single-pass membrane protein with aspartate-rich tail 1, mitochondrialBy similarity
Gene namesi
Name:SMDT1By similarity
Synonyms:EMREBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:35009 SMDT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 64Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei65 – 84HelicalSequence analysisAdd BLAST20
Topological domaini85 – 107Mitochondrial intermembraneBy similarityAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 47MitochondrionSequence analysisAdd BLAST47
ChainiPRO_000029632248 – 107Essential MCU regulator, mitochondrialAdd BLAST60

Post-translational modificationi

Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU.By similarity

Proteomic databases

PaxDbiQ2M2S2
PRIDEiQ2M2S2

Expressioni

Gene expression databases

BgeeiENSBTAG00000009508 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct. Interacts (via the poly-Asp region) with MICU1 (via polybasic region); the interaction is direct. Interacts (via its C-terminal poly-Asp tail) with MCUR1; the interaction is direct. Unprocessed form interacts (via transit peptide) with MAIP1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012511

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 85GXXXX[G/A/S]By similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 107Poly-AspSequence analysis6

Domaini

The GXXXX[G/A/S] motif at the C-terminal part of the transmembrane region mediates interaction with MCU and is required to activate the calcium-conducting pore in the uniporter complex.By similarity
The poly-Asp region at the C-terminus mediates interaction with the polybasic region of MICU1.By similarity

Sequence similaritiesi

Belongs to the SMDT1/EMRE family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4542 Eukaryota
ENOG4112ABK LUCA
GeneTreeiENSGT00390000017489
HOGENOMiHOG000018296
HOVERGENiHBG095170
InParanoidiQ2M2S2
KOiK22830
OMAiGPNLRKG
OrthoDBiEOG091G13VT
TreeFamiTF314649

Family and domain databases

InterProiView protein in InterPro
IPR018782 MCU_reg
PANTHERiPTHR33904 PTHR33904, 1 hit
PfamiView protein in Pfam
PF10161 DDDD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2M2S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGAARWLA LVRVGSGASR SWLSLRKGGD VSAGRSCSGQ SLVPTRSVIV
60 70 80 90 100
TRSGAILPKP VKMSFGLLRV FSIVIPFLYV GTLISKNFAA LLEEHDIFVP

EDDDDDD
Length:107
Mass (Da):11,450
Last modified:February 21, 2006 - v1
Checksum:iD0678EAC1B8178F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111682 mRNA Translation: AAI11683.1
RefSeqiNP_001039402.1, NM_001045937.1
UniGeneiBt.111482

Genome annotation databases

EnsembliENSBTAT00000012511; ENSBTAP00000012511; ENSBTAG00000009508
GeneIDi506149
KEGGibta:506149

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111682 mRNA Translation: AAI11683.1
RefSeqiNP_001039402.1, NM_001045937.1
UniGeneiBt.111482

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012511

Proteomic databases

PaxDbiQ2M2S2
PRIDEiQ2M2S2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012511; ENSBTAP00000012511; ENSBTAG00000009508
GeneIDi506149
KEGGibta:506149

Organism-specific databases

CTDi91689
VGNCiVGNC:35009 SMDT1

Phylogenomic databases

eggNOGiKOG4542 Eukaryota
ENOG4112ABK LUCA
GeneTreeiENSGT00390000017489
HOGENOMiHOG000018296
HOVERGENiHBG095170
InParanoidiQ2M2S2
KOiK22830
OMAiGPNLRKG
OrthoDBiEOG091G13VT
TreeFamiTF314649

Enzyme and pathway databases

ReactomeiR-BTA-8949215 Mitochondrial calcium ion transport
R-BTA-8949664 Processing of SMDT1

Gene expression databases

BgeeiENSBTAG00000009508 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR018782 MCU_reg
PANTHERiPTHR33904 PTHR33904, 1 hit
PfamiView protein in Pfam
PF10161 DDDD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMRE_BOVIN
AccessioniPrimary (citable) accession number: Q2M2S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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