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Entry version 116 (17 Jun 2020)
Sequence version 3 (03 Sep 2014)
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Protein

Probable maltase-glucoamylase 2

Gene

MGAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although it belongs to the glycosyl hydrolase 31 family, it lacks one active site residue, thus suggesting it may lack some enzyme activity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. EC:3.2.1.3

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei478NucleophilePROSITE-ProRule annotation1
Active sitei481By similarity1
Active sitei1375NucleophilePROSITE-ProRule annotation1
Active sitei1378By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH31 Glycoside Hydrolase Family 31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable maltase-glucoamylase 2Curated
Alternative name(s):
Maltase-glucoamylase (alpha-glucosidase) pseudogene
Including the following 1 domains:
Glucoamylase (EC:3.2.1.3)
Alternative name(s):
Glucan 1,4-alpha-glucosidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGAM2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000257743.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28101 MGAM2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M2H8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 482LumenalSequence analysisAdd BLAST452

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000257743

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2M2H8 Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3833502

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGAM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190359876

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413801 – 2515Probable maltase-glucoamylase 2Add BLAST2515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 72PROSITE-ProRule annotation
Disulfide bondi54 ↔ 71PROSITE-ProRule annotation
Disulfide bondi65 ↔ 84PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei371SulfotyrosineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi608 ↔ 619PROSITE-ProRule annotation
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi916 ↔ 933PROSITE-ProRule annotation
Disulfide bondi928 ↔ 946PROSITE-ProRule annotation
Modified residuei1238SulfotyrosineSequence analysis1
Glycosylationi2249N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2M2H8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2M2H8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q2M2H8

PeptideAtlas

More...
PeptideAtlasi
Q2M2H8

PRoteomics IDEntifications database

More...
PRIDEi
Q2M2H8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10955
61352 [Q2M2H8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M2H8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M2H8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000257743 Expressed in intestine and 36 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2M2H8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000257743 Group enriched (intestine, pancreas, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q2M2H8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000447431

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2M2H8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2M2H8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 88P-type 1PROSITE-ProRule annotationAdd BLAST48
Domaini904 – 950P-type 2PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 865MaltaseBy similarityAdd BLAST714
Regioni1023 – 1766GlucoamylaseBy similarityAdd BLAST744

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 31Poly-Leu7
Compositional biasi979 – 983Poly-Ala5
Compositional biasi1789 – 2503Thr-richAdd BLAST715

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000631_3_0_1

KEGG Orthology (KO)

More...
KOi
K12047

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVNSTYV

Database of Orthologous Groups

More...
OrthoDBi
151244at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00111 Trefoil, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR000519 P_trefoil_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00018 PD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 1 hit
PS00092 N6_MTASE, 1 hit
PS51448 P_TREFOIL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2M2H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARKLSVLEV LLIIFCLIVV TIDILLLLLV LEETSDTSFT PECPEIPQSE
60 70 80 90 100
RIDCTPDQEV TEDICRWQYK CCWSPVADAN VPRCFFPWNW GYEASNGHTN
110 120 130 140 150
TSTGFTAQLK RLPSPSLFGN DVATTLFTAE YQTSNRFHFK ITDFNNIRYE
160 170 180 190 200
VSHENINLVD GIADASNLSY YVEVTDKPFS IKIMRTSNRR VLLDTSIGPL
210 220 230 240 250
QFAQQYLQLS FRLPSANVYG LGEHVHQQYR HNMTWKTWPI FTRDATPTEG
260 270 280 290 300
MINLYGAHTF FLCLEDARGS SFGVFLMNSN AMEVTLQPAP AITYRTIGGI
310 320 330 340 350
LDFYVFLGNT PEQVVQEYLE LVGRPFFPPY WSLGFQLSRR DYGGINKLKE
360 370 380 390 400
VVSRNRLAEI PYDVQYSDID YMDGKKDFTV DEVAYSGLPD FVKELHDNGQ
410 420 430 440 450
KYLIIMNPGI SKNSNYEPYN NGSLKRVWIL GSNGFAVGEG YPGPTVFPDY
460 470 480 490 500
TNPVCTEWWT DQVAKFHDHL EFDGVWIEMN EVSSLLQASN NQCESNNLNF
510 520 530 540 550
PPFLPRVLDH LLFARTLCMD TEFHGGLHYD IHSLYGHSMA RTTNLALETI
560 570 580 590 600
FMNNRSFILS RSTFAGSGKF AAHWLGDNAA TWDDLRWSIP TILEFNLFGI
610 620 630 640 650
PMVGANICGY NNNVTEELCR RWMQLGAFYP LPRNHNGPGF RDQDPAAFGV
660 670 680 690 700
DSLLLKSSRH YLNIRYTLLP YLYTLFYHAH TRGETVARPL VHEFYQDSAT
710 720 730 740 750
WDVHEQFLWG PGLLITPVLY EGVDEVKAYI PDATWYDYET GVAISWRKQL
760 770 780 790 800
VNMLLPGDKI GLHLRGGYIF PTQKPNTTTE ASRRNSLGLI IALDYKREAK
810 820 830 840 850
GELYWDDGVS KDAVTEKKYI LYDFSVTSNH LQAKIINNNY MDTDNLMFTD
860 870 880 890 900
ITILGMDKQP ANFIVLLNNV ATSSPSVVYN ASTKVVTITD LQGLVLGQEF
910 920 930 940 950
SIRWNLPVSD LEKFNCYPDD PTASEESCRQ RGCLWEDTST PGVPTCYYDT
960 970 980 990 1000
IPNYVASDIQ YLNTSITADL SLPMAPESAA AAASDSLSAK ISFLHLKVIY
1010 1020 1030 1040 1050
HTATMLQVKI YDPTNKRYEV PVPLNTPPQP VGDPENRLYD VRIQNNPFGI
1060 1070 1080 1090 1100
QIQRKNSSTV IWDSQLPGFI FNDMFLSIST RLPSQYIYGF GETEHTTFRR
1110 1120 1130 1140 1150
NMNWNTWGMF AHDEPPAYKK NSYGVHPYYM ALEEDGSAHG VLLLNSNAMD
1160 1170 1180 1190 1200
VTLQPTPALT YRTTGGILDF YIVLGPTPEL VTQQYTELIG RPAMIPYWAL
1210 1220 1230 1240 1250
GFHLSRYGYQ NDAEISSLYD AMVAAQIPYD VQHVDIDYMN RKLDFTLSAN
1260 1270 1280 1290 1300
FQNLSLLIEQ MKKNGMRFIL ILDPAISGNE TQYLPFIRGQ ENNVFIKWPD
1310 1320 1330 1340 1350
TNDIVWGKVW PDLPNVIVDG SLDHETQVKL YRAYVAFPDF FRNSTAAWWK
1360 1370 1380 1390 1400
KEIEELYANP REPEKSLKFD GLWIDMNEPS NFVDGSVRGC SNEMLNNPPY
1410 1420 1430 1440 1450
MPYLESRDKG LSSKTLCMES QQILPDSSPV EHYNVHNLYG WSQTRPTYEA
1460 1470 1480 1490 1500
VQEVTGQRGV IITRSTFPSS GRWGGHRLGN NTAAWDQLGK SIIGMMEFSL
1510 1520 1530 1540 1550
FGIPYTGADI CGFFGDAEYE MCVRWMQLGA FYPFSRNHNN IGTRRQDPVA
1560 1570 1580 1590 1600
WNSTFEMLSR KVLETRYTLL PYLYTLMHKA HVEGSTVVRP LLHEFTDDRT
1610 1620 1630 1640 1650
TWDIDRQFML GPAILISPVL ETSTFEISAY FPRARWYDYS TGTSSTSTGQ
1660 1670 1680 1690 1700
RKILKAPLDH INLHVRGGYI LPWQEPAMNT HSSRQNFMGL IVALDDNGTA
1710 1720 1730 1740 1750
EGQVFWDDGQ SIDTYENGNY FLANFIAAQN ILQIQTIHNK YLSDSNPLKV
1760 1770 1780 1790 1800
GYIRIWGVNT YVTQVSFTYD NRQFMETNFK SEPYNQILTI QLTDKTINLE
1810 1820 1830 1840 1850
KLTEVTWIDG GPVLPTPTKT STIPMSSHPS PSTTNATSSE TITSSASANT
1860 1870 1880 1890 1900
TTGTTDTVPI TTTSFPSTTS VTTNTTVPDT TSPFPTSTTN ASTNATVPIT
1910 1920 1930 1940 1950
TTPFPTSTIG VTTNATVPNT TAPFPTNAST ASTNATVPIT TTCFATSTIG
1960 1970 1980 1990 2000
VTTNATVPDT TAPFPTNTTT ASTNATIPIT TTPFATSTIS VTTSTTVPDT
2010 2020 2030 2040 2050
TAPFPTSTTS ASTNATPVPI TTTLFATSTI GVTTGTTVPD TTAPFPTSTT
2060 2070 2080 2090 2100
STSTSATVPI TTTPSPTNTA DANTSNTVPN TTMPSPTSST TVSTIATVPI
2110 2120 2130 2140 2150
SVTPSLTSTA DATISTTVLI ATTSSLTGTT DVSTSTTINN ISTPVQTNTT
2160 2170 2180 2190 2200
NASTSTNVAN ITATSHTSTD DTVPNNTVPV TAIPSLANTG VDTTSNSFSI
2210 2220 2230 2240 2250
MTTSFSESTN AMNTTVIMAT TSPTSTDVAS TNNDASMTNF LLATMSAGNI
2260 2270 2280 2290 2300
TSNSISITTT SFGNSVPFVT TPSPSTDATT TSNNTNPGMT TYYQTSPTIP
2310 2320 2330 2340 2350
THTLTSIPSS ITSILSMFPT SNTFTTDKIT NFTTPTNANT IIFNTLDTKS
2360 2370 2380 2390 2400
TMVIDATVTT TSTKDNTMSP DTTVTSIDKF TTHITQFATP HSATTTTLAL
2410 2420 2430 2440 2450
SHTSLAPTNL SNLGTMDITD ADNSSSVTGN TTHISVSNLT TASVTITATG
2460 2470 2480 2490 2500
LDSQTPHMVI NSVATYLPIT ATSATTDTTN ITKYALNTTT PDSTVHTSAT
2510
APTYIANAIN ATQVP
Length:2,515
Mass (Da):277,990
Last modified:September 3, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6E8F08987335A4F
GO
Isoform 2 (identifier: Q2M2H8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-482: EMNEV → VSYYS
     483-2515: Missing.

Show »
Length:482
Mass (Da):55,146
Checksum:i94EF4964B0B4E4AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti327F → L in BC111973 (PubMed:15489334).Curated1
Sequence conflicti327F → L in BC111975 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055415478 – 482EMNEV → VSYYS in isoform 2. 1 Publication5
Alternative sequenceiVSP_055416483 – 2515Missing in isoform 2. 1 PublicationAdd BLAST2033

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC091742 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23771.1
CH471198 Genomic DNA Translation: EAW51984.1
BC111973 mRNA No translation available.
BC111975 mRNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001280555.1, NM_001293626.1 [Q2M2H8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000477922; ENSP00000420449; ENSG00000257743 [Q2M2H8-1]
ENST00000550469; ENSP00000447431; ENSG00000257743 [Q2M2H8-3]
ENST00000622623; ENSP00000484330; ENSG00000278563 [Q2M2H8-3]
ENST00000632823; ENSP00000488423; ENSG00000278563 [Q2M2H8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93432

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:93432

UCSC genome browser

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UCSCi
uc064isf.1 human [Q2M2H8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091742 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23771.1
CH471198 Genomic DNA Translation: EAW51984.1
BC111973 mRNA No translation available.
BC111975 mRNA No translation available.
RefSeqiNP_001280555.1, NM_001293626.1 [Q2M2H8-1]

3D structure databases

SMRiQ2M2H8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ2M2H8, 1 interactor
STRINGi9606.ENSP00000447431

Chemistry databases

ChEMBLiCHEMBL3833502

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

PTM databases

iPTMnetiQ2M2H8
PhosphoSitePlusiQ2M2H8

Polymorphism and mutation databases

BioMutaiMGAM2
DMDMi190359876

Proteomic databases

EPDiQ2M2H8
jPOSTiQ2M2H8
MassIVEiQ2M2H8
PeptideAtlasiQ2M2H8
PRIDEiQ2M2H8
ProteomicsDBi10955
61352 [Q2M2H8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
70894 4 antibodies

Genome annotation databases

EnsembliENST00000477922; ENSP00000420449; ENSG00000257743 [Q2M2H8-1]
ENST00000550469; ENSP00000447431; ENSG00000257743 [Q2M2H8-3]
ENST00000622623; ENSP00000484330; ENSG00000278563 [Q2M2H8-3]
ENST00000632823; ENSP00000488423; ENSG00000278563 [Q2M2H8-1]
GeneIDi93432
KEGGihsa:93432
UCSCiuc064isf.1 human [Q2M2H8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93432
EuPathDBiHostDB:ENSG00000257743.8

GeneCards: human genes, protein and diseases

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GeneCardsi
MGAM2
HGNCiHGNC:28101 MGAM2
HPAiENSG00000257743 Group enriched (intestine, pancreas, salivary gland)
neXtProtiNX_Q2M2H8
OpenTargetsiENSG00000257743

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163091
HOGENOMiCLU_000631_3_0_1
KOiK12047
OMAiGVNSTYV
OrthoDBi151244at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
93432 0 hits in 2 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MGAM2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93432
PharosiQ2M2H8 Tdark

Protein Ontology

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PROi
PR:Q2M2H8
RNActiQ2M2H8 protein

Gene expression databases

BgeeiENSG00000257743 Expressed in intestine and 36 other tissues
GenevisibleiQ2M2H8 HS

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 1 hit
PS00092 N6_MTASE, 1 hit
PS51448 P_TREFOIL_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGAL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M2H8
Secondary accession number(s): A4D2I3, C9JNC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 3, 2014
Last modified: June 17, 2020
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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