UniProtKB - Q2M2E3 (ODFP4_HUMAN)
Protein
Outer dense fiber protein 4
Gene
ODF4
Organism
Homo sapiens (Human)
Status
Functioni
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.By similarity
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q2M2E3 |
Names & Taxonomyi
Protein namesi | Recommended name: Outer dense fiber protein 4Alternative name(s): Outer dense fiber of sperm tails protein 4 Testis-specific protein oppo 1 Short name: hOPPO1 |
Gene namesi | Name:ODF4 Synonyms:OPPO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19056, ODF4 |
MIMi | 610097, gene |
neXtProti | NX_Q2M2E3 |
VEuPathDBi | HostDB:ENSG00000184650.9 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 80 – 100 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146852 |
OpenTargetsi | ENSG00000184650 |
PharmGKBi | PA134978853 |
Miscellaneous databases
Pharosi | Q2M2E3, Tdark |
Genetic variation databases
BioMutai | ODF4 |
DMDMi | 158564291 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304722 | 1 – 257 | Outer dense fiber protein 4Add BLAST | 257 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q2M2E3 |
PRIDEi | Q2M2E3 |
ProteomicsDBi | 61350 |
PTM databases
iPTMneti | Q2M2E3 |
PhosphoSitePlusi | Q2M2E3 |
Expressioni
Tissue specificityi
Expressed in testis and sperm; especially localized to sperm tail (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000184650, Expressed in left testis and 45 other tissues |
ExpressionAtlasi | Q2M2E3, baseline and differential |
Genevisiblei | Q2M2E3, HS |
Organism-specific databases
HPAi | ENSG00000184650, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ2M2E3
Protein-protein interaction databases
BioGRIDi | 127017, 26 interactors |
IntActi | Q2M2E3, 23 interactors |
STRINGi | 9606.ENSP00000331086 |
Miscellaneous databases
RNActi | Q2M2E3, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SXVG, Eukaryota |
GeneTreei | ENSGT00940000163675 |
HOGENOMi | CLU_062754_1_0_1 |
InParanoidi | Q2M2E3 |
OMAi | RWPVDVS |
OrthoDBi | 1432634at2759 |
PhylomeDBi | Q2M2E3 |
TreeFami | TF338228 |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q2M2E3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL
60 70 80 90 100
SLSSNRSLGQ RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF
110 120 130 140 150
SKKWLDLSRS LFYQRWPVDV SNRIHTSAHV MSMGLLHFYK SRSCSDLENG
160 170 180 190 200
KVTFIFSTLM LFPINIWIFE LERNVSIPIG WSYFIGWLVL ILYFTCAILC
210 220 230 240 250
YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT PITQEGVLDP
EQKDTHV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC3TX97 | C3TX97_HUMAN | Outer dense fiber 4 | ODF4 | 142 | Annotation score: | ||
A0A1B0GUG5 | A0A1B0GUG5_HUMAN | Outer dense fiber protein 4 | ODF4 | 52 | Annotation score: | ||
A0A1B0GUE2 | A0A1B0GUE2_HUMAN | Outer dense fiber protein 4 | ODF4 | 32 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035060 | 34 | W → R1 PublicationCorresponds to variant dbSNP:rs12943505Ensembl. | 1 | |
Natural variantiVAR_035061 | 98 | V → M3 PublicationsCorresponds to variant dbSNP:rs12601097Ensembl. | 1 | |
Natural variantiVAR_035062 | 139 | Y → C3 PublicationsCorresponds to variant dbSNP:rs12936935Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB081120 mRNA Translation: BAC15594.1 AY237799 mRNA Translation: AAO89569.1 BC112010 mRNA Translation: AAI12011.1 BC112014 mRNA Translation: AAI12015.1 |
CCDSi | CCDS11140.1 |
RefSeqi | NP_694552.2, NM_153007.4 |
Genome annotation databases
Ensembli | ENST00000328248; ENSP00000331086; ENSG00000184650 |
GeneIDi | 146852 |
KEGGi | hsa:146852 |
UCSCi | uc002gle.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB081120 mRNA Translation: BAC15594.1 AY237799 mRNA Translation: AAO89569.1 BC112010 mRNA Translation: AAI12011.1 BC112014 mRNA Translation: AAI12015.1 |
CCDSi | CCDS11140.1 |
RefSeqi | NP_694552.2, NM_153007.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127017, 26 interactors |
IntActi | Q2M2E3, 23 interactors |
STRINGi | 9606.ENSP00000331086 |
PTM databases
iPTMneti | Q2M2E3 |
PhosphoSitePlusi | Q2M2E3 |
Genetic variation databases
BioMutai | ODF4 |
DMDMi | 158564291 |
Proteomic databases
PaxDbi | Q2M2E3 |
PRIDEi | Q2M2E3 |
ProteomicsDBi | 61350 |
Protocols and materials databases
Antibodypediai | 42968, 54 antibodies |
Genome annotation databases
Ensembli | ENST00000328248; ENSP00000331086; ENSG00000184650 |
GeneIDi | 146852 |
KEGGi | hsa:146852 |
UCSCi | uc002gle.2, human |
Organism-specific databases
CTDi | 146852 |
DisGeNETi | 146852 |
GeneCardsi | ODF4 |
HGNCi | HGNC:19056, ODF4 |
HPAi | ENSG00000184650, Tissue enriched (testis) |
MIMi | 610097, gene |
neXtProti | NX_Q2M2E3 |
OpenTargetsi | ENSG00000184650 |
PharmGKBi | PA134978853 |
VEuPathDBi | HostDB:ENSG00000184650.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SXVG, Eukaryota |
GeneTreei | ENSGT00940000163675 |
HOGENOMi | CLU_062754_1_0_1 |
InParanoidi | Q2M2E3 |
OMAi | RWPVDVS |
OrthoDBi | 1432634at2759 |
PhylomeDBi | Q2M2E3 |
TreeFami | TF338228 |
Enzyme and pathway databases
PathwayCommonsi | Q2M2E3 |
Miscellaneous databases
BioGRID-ORCSi | 146852, 5 hits in 864 CRISPR screens |
GenomeRNAii | 146852 |
Pharosi | Q2M2E3, Tdark |
PROi | PR:Q2M2E3 |
RNActi | Q2M2E3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184650, Expressed in left testis and 45 other tissues |
ExpressionAtlasi | Q2M2E3, baseline and differential |
Genevisiblei | Q2M2E3, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ODFP4_HUMAN | |
Accessioni | Q2M2E3Primary (citable) accession number: Q2M2E3 Secondary accession number(s): Q8J021 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot