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Entry version 92 (13 Feb 2019)
Sequence version 2 (02 May 2006)
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Protein

Coiled-coil domain-containing protein 27

Gene

CCDC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162592.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26546 CCDC27

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M243

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
148870

Open Targets

More...
OpenTargetsi
ENSG00000162592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672185

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
94707506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340201 – 656Coiled-coil domain-containing protein 27Add BLAST656

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2M243

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2M243

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2M243

PeptideAtlas

More...
PeptideAtlasi
Q2M243

PRoteomics IDEntifications database

More...
PRIDEi
Q2M243

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61346

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162592 Expressed in 32 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2M243 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2M243 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127177, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q2M243, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q2M243

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2M243

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili241 – 278Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi310 – 419Glu-richAdd BLAST110

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKJN Eukaryota
ENOG410YUWN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154171

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049243

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058590

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2M243

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPWYISV

Database of Orthologous Groups

More...
OrthoDBi
814498at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2M243

TreeFam database of animal gene trees

More...
TreeFami
TF335685

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q2M243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEAIFPSTP QARLKRDPRE KPGLSSFRST FRQQSSLGLC IPRLMLPKEA
60 70 80 90 100
SPSQRHSSMS SSMARALVLL QSMASRDARC PEWKPHQKPR TLSKSVQTIS
110 120 130 140 150
RYYRKTSEPK DAASLTGFMS KMELRRVFPT HPDCPQFSTR ATSMSHCGSP
160 170 180 190 200
TEADLSGEID NSSETWRGTQ DLFLARRGSD TNVDGYLLPF SKSICEFDYL
210 220 230 240 250
RKRRKSQTLS PVTSSSVASQ SCLRKRMPWY LSVIHEKDHC LSELEIQVQK
260 270 280 290 300
KDEEILLLQE EREALKMQLK CLLKGKGQET SMSPGRREQL SDASLKLGRL
310 320 330 340 350
SLLKAFSRHE EELQHWWQMQ EESAAPERGK EPDLGGGEED EGLEGEPDGV
360 370 380 390 400
EDTGAWGGVS QMGSVHEEGS EEEEEEEGDR DEDSEERELP EEEEIPRRRA
410 420 430 440 450
SSLAESFEEE LLAQLEEYEQ VILDFQFNLE ATRTRYSLAT GVIASLQQQV
460 470 480 490 500
DFQETQLRKI NTENETLQKE LRERRQQLQA MTDKFSNLRE DKKHQEMMGL
510 520 530 540 550
IEKDNQLLRQ QVSELERKLT KRDCVISELD TKVSQLQEQV ELDQNHLQRW
560 570 580 590 600
KQLQEDLQSK KEMIQQAEQH TRVALESSQS RLERLRNKII QATFSISGTK
610 620 630 640 650
SLANEISDND ILEALQRIIS ERSDYYNQLK QKGVKVPPLQ QSEAFLTSKS

KKGTSK
Length:656
Mass (Da):75,354
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08F4420F767498F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKX2J3QKX2_HUMAN
Coiled-coil domain-containing prote...
CCDC27
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43R → C in BAB71462 (PubMed:14702039).Curated1
Sequence conflicti380R → K in BAB71462 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02615954Q → E2 PublicationsCorresponds to variant dbSNP:rs10910021Ensembl.1
Natural variantiVAR_026160267M → T2 PublicationsCorresponds to variant dbSNP:rs1181883Ensembl.1
Natural variantiVAR_026161353T → M1 PublicationCorresponds to variant dbSNP:rs10910024Ensembl.1
Natural variantiVAR_056777390P → L. Corresponds to variant dbSNP:rs11806371Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057387 mRNA Translation: BAB71462.1
AL136528 Genomic DNA No translation available.
AL365330 Genomic DNA No translation available.
BC112108 mRNA Translation: AAI12109.1
BC112112 mRNA Translation: AAI12113.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50.1

NCBI Reference Sequences

More...
RefSeqi
NP_689705.2, NM_152492.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.348700

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294600; ENSP00000294600; ENSG00000162592

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148870

UCSC genome browser

More...
UCSCi
uc001akv.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057387 mRNA Translation: BAB71462.1
AL136528 Genomic DNA No translation available.
AL365330 Genomic DNA No translation available.
BC112108 mRNA Translation: AAI12109.1
BC112112 mRNA Translation: AAI12113.1
CCDSiCCDS50.1
RefSeqiNP_689705.2, NM_152492.2
UniGeneiHs.348700

3D structure databases

ProteinModelPortaliQ2M243
SMRiQ2M243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127177, 6 interactors
IntActiQ2M243, 2 interactors
STRINGi9606.ENSP00000294600

PTM databases

iPTMnetiQ2M243
PhosphoSitePlusiQ2M243

Polymorphism and mutation databases

BioMutaiCCDC27
DMDMi94707506

Proteomic databases

EPDiQ2M243
MaxQBiQ2M243
PaxDbiQ2M243
PeptideAtlasiQ2M243
PRIDEiQ2M243
ProteomicsDBi61346

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294600; ENSP00000294600; ENSG00000162592
GeneIDi148870
KEGGihsa:148870
UCSCiuc001akv.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148870
DisGeNETi148870
EuPathDBiHostDB:ENSG00000162592.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC27
HGNCiHGNC:26546 CCDC27
neXtProtiNX_Q2M243
OpenTargetsiENSG00000162592
PharmGKBiPA142672185

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKJN Eukaryota
ENOG410YUWN LUCA
GeneTreeiENSGT00940000154171
HOGENOMiHOG000049243
HOVERGENiHBG058590
InParanoidiQ2M243
OMAiMPWYISV
OrthoDBi814498at2759
PhylomeDBiQ2M243
TreeFamiTF335685

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
148870

Protein Ontology

More...
PROi
PR:Q2M243

Gene expression databases

BgeeiENSG00000162592 Expressed in 32 organ(s), highest expression level in right testis
ExpressionAtlasiQ2M243 baseline and differential
GenevisibleiQ2M243 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M243
Secondary accession number(s): Q5TBV3, Q96M50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: February 13, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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