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Protein

Coiled-coil domain-containing protein 27

Gene

CCDC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 27
Gene namesi
Name:CCDC27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162592.8
HGNCiHGNC:26546 CCDC27
neXtProtiNX_Q2M243

Pathology & Biotechi

Organism-specific databases

DisGeNETi148870
OpenTargetsiENSG00000162592
PharmGKBiPA142672185

Polymorphism and mutation databases

BioMutaiCCDC27
DMDMi94707506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340201 – 656Coiled-coil domain-containing protein 27Add BLAST656

Proteomic databases

EPDiQ2M243
MaxQBiQ2M243
PaxDbiQ2M243
PeptideAtlasiQ2M243
PRIDEiQ2M243
ProteomicsDBi61346

PTM databases

iPTMnetiQ2M243
PhosphoSitePlusiQ2M243

Expressioni

Gene expression databases

BgeeiENSG00000162592 Expressed in 32 organ(s), highest expression level in right testis
CleanExiHS_CCDC27
ExpressionAtlasiQ2M243 baseline and differential
GenevisibleiQ2M243 HS

Interactioni

Protein-protein interaction databases

BioGridi127177, 6 interactors
IntActiQ2M243, 1 interactor
STRINGi9606.ENSP00000294600

Structurei

3D structure databases

ProteinModelPortaliQ2M243
SMRiQ2M243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili241 – 278Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi310 – 419Glu-richAdd BLAST110

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKJN Eukaryota
ENOG410YUWN LUCA
GeneTreeiENSGT00510000049355
HOGENOMiHOG000049243
HOVERGENiHBG058590
InParanoidiQ2M243
OMAiMPWYISV
OrthoDBiEOG091G0EFZ
PhylomeDBiQ2M243
TreeFamiTF335685

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q2M243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEAIFPSTP QARLKRDPRE KPGLSSFRST FRQQSSLGLC IPRLMLPKEA
60 70 80 90 100
SPSQRHSSMS SSMARALVLL QSMASRDARC PEWKPHQKPR TLSKSVQTIS
110 120 130 140 150
RYYRKTSEPK DAASLTGFMS KMELRRVFPT HPDCPQFSTR ATSMSHCGSP
160 170 180 190 200
TEADLSGEID NSSETWRGTQ DLFLARRGSD TNVDGYLLPF SKSICEFDYL
210 220 230 240 250
RKRRKSQTLS PVTSSSVASQ SCLRKRMPWY LSVIHEKDHC LSELEIQVQK
260 270 280 290 300
KDEEILLLQE EREALKMQLK CLLKGKGQET SMSPGRREQL SDASLKLGRL
310 320 330 340 350
SLLKAFSRHE EELQHWWQMQ EESAAPERGK EPDLGGGEED EGLEGEPDGV
360 370 380 390 400
EDTGAWGGVS QMGSVHEEGS EEEEEEEGDR DEDSEERELP EEEEIPRRRA
410 420 430 440 450
SSLAESFEEE LLAQLEEYEQ VILDFQFNLE ATRTRYSLAT GVIASLQQQV
460 470 480 490 500
DFQETQLRKI NTENETLQKE LRERRQQLQA MTDKFSNLRE DKKHQEMMGL
510 520 530 540 550
IEKDNQLLRQ QVSELERKLT KRDCVISELD TKVSQLQEQV ELDQNHLQRW
560 570 580 590 600
KQLQEDLQSK KEMIQQAEQH TRVALESSQS RLERLRNKII QATFSISGTK
610 620 630 640 650
SLANEISDND ILEALQRIIS ERSDYYNQLK QKGVKVPPLQ QSEAFLTSKS

KKGTSK
Length:656
Mass (Da):75,354
Last modified:May 2, 2006 - v2
Checksum:i08F4420F767498F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKX2J3QKX2_HUMAN
Coiled-coil domain-containing prote...
CCDC27
202Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43R → C in BAB71462 (PubMed:14702039).Curated1
Sequence conflicti380R → K in BAB71462 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02615954Q → E2 PublicationsCorresponds to variant dbSNP:rs10910021Ensembl.1
Natural variantiVAR_026160267M → T2 PublicationsCorresponds to variant dbSNP:rs1181883Ensembl.1
Natural variantiVAR_026161353T → M1 PublicationCorresponds to variant dbSNP:rs10910024Ensembl.1
Natural variantiVAR_056777390P → L. Corresponds to variant dbSNP:rs11806371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057387 mRNA Translation: BAB71462.1
AL136528 Genomic DNA No translation available.
AL365330 Genomic DNA No translation available.
BC112108 mRNA Translation: AAI12109.1
BC112112 mRNA Translation: AAI12113.1
CCDSiCCDS50.1
RefSeqiNP_689705.2, NM_152492.2
UniGeneiHs.348700

Genome annotation databases

EnsembliENST00000294600; ENSP00000294600; ENSG00000162592
GeneIDi148870
KEGGihsa:148870
UCSCiuc001akv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057387 mRNA Translation: BAB71462.1
AL136528 Genomic DNA No translation available.
AL365330 Genomic DNA No translation available.
BC112108 mRNA Translation: AAI12109.1
BC112112 mRNA Translation: AAI12113.1
CCDSiCCDS50.1
RefSeqiNP_689705.2, NM_152492.2
UniGeneiHs.348700

3D structure databases

ProteinModelPortaliQ2M243
SMRiQ2M243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127177, 6 interactors
IntActiQ2M243, 1 interactor
STRINGi9606.ENSP00000294600

PTM databases

iPTMnetiQ2M243
PhosphoSitePlusiQ2M243

Polymorphism and mutation databases

BioMutaiCCDC27
DMDMi94707506

Proteomic databases

EPDiQ2M243
MaxQBiQ2M243
PaxDbiQ2M243
PeptideAtlasiQ2M243
PRIDEiQ2M243
ProteomicsDBi61346

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294600; ENSP00000294600; ENSG00000162592
GeneIDi148870
KEGGihsa:148870
UCSCiuc001akv.3 human

Organism-specific databases

CTDi148870
DisGeNETi148870
EuPathDBiHostDB:ENSG00000162592.8
GeneCardsiCCDC27
HGNCiHGNC:26546 CCDC27
neXtProtiNX_Q2M243
OpenTargetsiENSG00000162592
PharmGKBiPA142672185
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJN Eukaryota
ENOG410YUWN LUCA
GeneTreeiENSGT00510000049355
HOGENOMiHOG000049243
HOVERGENiHBG058590
InParanoidiQ2M243
OMAiMPWYISV
OrthoDBiEOG091G0EFZ
PhylomeDBiQ2M243
TreeFamiTF335685

Miscellaneous databases

GenomeRNAii148870
PROiPR:Q2M243

Gene expression databases

BgeeiENSG00000162592 Expressed in 32 organ(s), highest expression level in right testis
CleanExiHS_CCDC27
ExpressionAtlasiQ2M243 baseline and differential
GenevisibleiQ2M243 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD27_HUMAN
AccessioniPrimary (citable) accession number: Q2M243
Secondary accession number(s): Q5TBV3, Q96M50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: September 12, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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