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Entry version 126 (11 Dec 2019)
Sequence version 1 (21 Feb 2006)
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Protein

Zinc finger protein 630

Gene

ZNF630

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri263 – 285C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 630
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF630
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000221994.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28855 ZNF630

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300819 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M218

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000221994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134889031

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2M218 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF630

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97219357

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346031 – 657Zinc finger protein 630Add BLAST657

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2M218

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q2M218

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2M218

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2M218

PeptideAtlas

More...
PeptideAtlasi
Q2M218

PRoteomics IDEntifications database

More...
PRIDEi
Q2M218

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30492
61344 [Q2M218-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M218

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M218

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000221994 Expressed in 132 organ(s), highest expression level in left ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2M218 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2M218 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001053
HPA068130

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393163

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2M218 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2M218

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2M218

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
YECFECQ

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2M218

TreeFam database of animal gene trees

More...
TreeFami
TF337898

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2M218-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIESQEPVTF EDVAVDFTQE EWQQLNPAQK TLHRDVMLET YNHLVSVGCS
60 70 80 90 100
GIKPDVIFKL EHGKDPWIIE SELSRWIYPD RVKGLESSQQ IISGELLFQR
110 120 130 140 150
EILERAPKDN SLYSVLKIWH IDNQMDRYQG NQDRVLRQVT VISRETLTDE
160 170 180 190 200
MGSKYSAFGK MFNRCTDLAP LSQKFHKFDS CENSLKSNSD LLNYNRSYAR
210 220 230 240 250
KNPTKRFRCG RPPKYNASCS VPEKEGFIHT GMEPYGDSQC EKVLSHKQAH
260 270 280 290 300
VQYKKFQARE KPNVCSMCGK AFIKKSQLII HQRIHTGEKP YVCGDCRKAF
310 320 330 340 350
SEKSHLIVHQ RIHTGEKPYE CTKYGRAFSR KSPFTVHQRV HTGEKPYECF
360 370 380 390 400
ECPKAFSQKS HLIIHQRVHT REKPFECSEC RKAFCEMSHL FIHQITHTGK
410 420 430 440 450
KPYECTECGK TFPRKTQLII HQRTHTGEKP YKCGECGKTF CQQSHLIGHQ
460 470 480 490 500
RIHTGEKPYV CTDCGKAFSQ KSHLTGHQRL HTGEKPYMCT ECGKSFSQKS
510 520 530 540 550
PLIIHQRIHT GEKPYQCGEC GKTFSQKSLL IIHLRVHTGE KPYECTECGR
560 570 580 590 600
AFSLKSHLIL HQRGHTGEKP YECSECGKAF CGKSPLIIHQ KTHPREKTPE
610 620 630 640 650
CAESGMTFFW KSQMITYQRR HTGEKPSRCS DCGKAFCQHV YFTGHQNPYR

KDTLYIC
Length:657
Mass (Da):76,094
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0902CC9CE709EE7B
GO
Isoform 2 (identifier: Q2M218-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-20: Missing.

Show »
Length:643
Mass (Da):74,515
Checksum:i4BE547F926940384
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXA8A0A087WXA8_HUMAN
Zinc finger protein 630
ZNF630
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2ZWG8B2ZWG8_HUMAN
Zinc finger protein 630
ZNF630
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCH7F8WCH7_HUMAN
Zinc finger protein 630
ZNF630
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SER6A0A0D9SER6_HUMAN
Zinc finger protein 630
ZNF630
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2ZWH0B2ZWH0_HUMAN
HCG1771495, isoform CRA_b
ZNF630 hCG_1771495
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2ZWG9B2ZWG9_HUMAN
Zinc finger protein 630
ZNF630
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146T → H in BX419623 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468557 – 20Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z98304 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59337.1
BC112139 mRNA Translation: AAI12140.3
BX419623 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35237.2 [Q2M218-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001032824.2, NM_001037735.3 [Q2M218-1]
NP_001177184.1, NM_001190255.2 [Q2M218-2]
NP_001269130.1, NM_001282201.1 [Q2M218-1]
NP_001269131.1, NM_001282202.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409324; ENSP00000386393; ENSG00000221994 [Q2M218-1]
ENST00000442455; ENSP00000393163; ENSG00000221994 [Q2M218-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57232

UCSC genome browser

More...
UCSCi
uc004div.5 human [Q2M218-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98304 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59337.1
BC112139 mRNA Translation: AAI12140.3
BX419623 mRNA No translation available.
CCDSiCCDS35237.2 [Q2M218-1]
RefSeqiNP_001032824.2, NM_001037735.3 [Q2M218-1]
NP_001177184.1, NM_001190255.2 [Q2M218-2]
NP_001269130.1, NM_001282201.1 [Q2M218-1]
NP_001269131.1, NM_001282202.1

3D structure databases

SMRiQ2M218
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393163

PTM databases

iPTMnetiQ2M218
PhosphoSitePlusiQ2M218

Polymorphism and mutation databases

BioMutaiZNF630
DMDMi97219357

Proteomic databases

jPOSTiQ2M218
MassIVEiQ2M218
MaxQBiQ2M218
PaxDbiQ2M218
PeptideAtlasiQ2M218
PRIDEiQ2M218
ProteomicsDBi30492
61344 [Q2M218-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57232

Genome annotation databases

EnsembliENST00000409324; ENSP00000386393; ENSG00000221994 [Q2M218-1]
ENST00000442455; ENSP00000393163; ENSG00000221994 [Q2M218-1]
GeneIDi57232
KEGGihsa:57232
UCSCiuc004div.5 human [Q2M218-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57232
EuPathDBiHostDB:ENSG00000221994.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF630
HGNCiHGNC:28855 ZNF630
HPAiHPA001053
HPA068130
MIMi300819 gene
neXtProtiNX_Q2M218
OpenTargetsiENSG00000221994
PharmGKBiPA134889031

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163698
HOGENOMiHOG000234617
InParanoidiQ2M218
KOiK09228
OMAiYECFECQ
OrthoDBi1318335at2759
PhylomeDBiQ2M218
TreeFamiTF337898

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57232
PharosiQ2M218 Tdark

Protein Ontology

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PROi
PR:Q2M218
RNActiQ2M218 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000221994 Expressed in 132 organ(s), highest expression level in left ovary
ExpressionAtlasiQ2M218 baseline and differential
GenevisibleiQ2M218 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN630_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M218
Secondary accession number(s): F8WAG4, Q5H8Z5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 21, 2006
Last modified: December 11, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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