UniProtKB - Q2M204 (Q2M204_HUMAN)
Protein
RING-type E3 ubiquitin transferase
Gene
TRIM50
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
GO - Molecular functioni
- transferase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- regulation of establishment of protein localization Source: Ensembl
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TRIM50Imported ORF Names:hCG_1642804Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000146755.10 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSG00000146755, Expressed in body of stomach and 93 other tissues |
ExpressionAtlasi | Q2M204, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 57 | RING-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 84 – 125 | B box-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 276 – 475 | B30.2/SPRYInterPro annotationAdd BLAST | 200 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 468 – 487 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 129 – 163 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 205 – 225 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_013137_0_3_1 |
OMAi | DVCWHER |
OrthoDBi | 574602at2759 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2M204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAWQVSLPEL EDRLQCPICL EVFKEPLMLQ CGHSYCKGCL VSLSCHLDAE
60 70 80 90 100
LRCPVCRQAV DGSSSLPNVS LARVIEALRL PGDPEPKVCV HHRNPLSLFC
110 120 130 140 150
EKDQELICGL CGLLGSHQHH PVTPVSTVYS RMKEELAALI SELKQEQKKV
160 170 180 190 200
DELIAKLVNN RTRIVNESDV FSWVIRREFQ ELHHLVDEEK ARCLEGIGGH
210 220 230 240 250
TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHKF IRKFHSMASR
260 270 280 290 300
AEMPQARPLE GAFSPISFKP GLHQADIKLT VWKRLFRKVL PAPEPLKLDP
310 320 330 340 350
ATAHPLLELS KGNTVVQCGL LAQRRASQPE RFDYSTCVLA SRGFSCGRHY
360 370 380 390 400
WEVVVGSKSD WRLGVIKGTA SRKGKLNRSP EHGVWLIGLK EGRVYEAFAC
410 420 430 440 450
PRVPLPVAGH PHRIGLYLHY EQGELTFFDA DRPDDLRPLY TFQADFQGKL
460 470 480
YPILDTCWHE RGSNSLPMVL PPPSGPGPLS PEQPTKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112152 mRNA Translation: AAI12153.1 BC112154 mRNA Translation: AAI12155.1 AK292074 mRNA Translation: BAF84763.1 CH471200 Genomic DNA Translation: EAW69688.1 CH471200 Genomic DNA Translation: EAW69691.1 |
RefSeqi | NP_001268380.1, NM_001281451.1 NP_835226.2, NM_178125.3 |
Genome annotation databases
GeneIDi | 135892 |
KEGGi | hsa:135892 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112152 mRNA Translation: AAI12153.1 BC112154 mRNA Translation: AAI12155.1 AK292074 mRNA Translation: BAF84763.1 CH471200 Genomic DNA Translation: EAW69688.1 CH471200 Genomic DNA Translation: EAW69691.1 |
RefSeqi | NP_001268380.1, NM_001281451.1 NP_835226.2, NM_178125.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 14287, 130 antibodies |
Genome annotation databases
GeneIDi | 135892 |
KEGGi | hsa:135892 |
Organism-specific databases
CTDi | 135892 |
VEuPathDBi | HostDB:ENSG00000146755.10 |
Phylogenomic databases
HOGENOMi | CLU_013137_0_3_1 |
OMAi | DVCWHER |
OrthoDBi | 574602at2759 |
Miscellaneous databases
BioGRID-ORCSi | 135892, 7 hits in 871 CRISPR screens |
ChiTaRSi | TRIM50, human |
GenomeRNAii | 135892 |
Gene expression databases
Bgeei | ENSG00000146755, Expressed in body of stomach and 93 other tissues |
ExpressionAtlasi | Q2M204, baseline and differential |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2M204_HUMAN | |
Accessioni | Q2M204Primary (citable) accession number: Q2M204 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 21, 2006 |
Last sequence update: | February 21, 2006 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |