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Entry version 100 (07 Oct 2020)
Sequence version 1 (21 Feb 2006)
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Protein
Submitted name:

ROBO1 protein

Gene

ROBO1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ROBO1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROBO1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q2M1J3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q2M1J3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2M1J3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 125Ig-likeInterPro annotationAdd BLAST97
Domaini131 – 218Ig-likeInterPro annotationAdd BLAST88
Domaini223 – 307Ig-likeInterPro annotationAdd BLAST85
Domaini315 – 410Ig-likeInterPro annotationAdd BLAST96
Domaini419 – 505Ig-likeInterPro annotationAdd BLAST87
Domaini527 – 621Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini640 – 737Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini742 – 838Fibronectin type-IIIInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1079 – 1158DisorderedSequence analysisAdd BLAST80
Regioni1180 – 1293DisorderedSequence analysisAdd BLAST114
Regioni1308 – 1353DisorderedSequence analysisAdd BLAST46
Regioni1376 – 1607DisorderedSequence analysisAdd BLAST232

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1088 – 1121PolarSequence analysisAdd BLAST34
Compositional biasi1207 – 1227PolarSequence analysisAdd BLAST21
Compositional biasi1249 – 1264Pro-richSequence analysisAdd BLAST16
Compositional biasi1313 – 1353PolarSequence analysisAdd BLAST41
Compositional biasi1394 – 1411PolarSequence analysisAdd BLAST18
Compositional biasi1472 – 1495PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1510 – 1533PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1546 – 1577PolarSequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Immunoglobulin domainARBA annotation, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR032986, Robo1

The PANTHER Classification System

More...
PANTHERi
PTHR12231:SF243, PTHR12231:SF243, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2M1J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC
60 70 80 90 100
KAEGRPTPTI EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR
110 120 130 140 150
PDEGVYVCVA RNYLGEAVSH NASLEVAILR DDFRQNPSDV MVAVGEPAVM
160 170 180 190 200
ECQPPRGHPE PTISWKKDGS PLDDKDERIT IRGGKLMITY TRKSDAGKYV
210 220 230 240 250
CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA EFKCEARGDP
260 270 280 290 300
VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA
310 320 330 340 350
EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR
360 370 380 390 400
EGSQNLLFSY QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS
410 420 430 440 450
IITKAYLEVT DVIADRPPPV IRQGPVNQTV AVDGTFVLSC VATGSPVPTI
460 470 480 490 500
LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK LGDTGRYTCI ASTPSGEATW
510 520 530 540 550
SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT VTLSWQPNLN
560 570 580 590 600
SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA
610 620 630 640 650
ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL
660 670 680 690 700
SSSSIEVHWT VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV
710 720 730 740 750
VIPDLRKGVN YEIKARPFFN EFQGADSEIK FAKTLEEAPS APPQGVTVSK
760 770 780 790 800
NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW CLGNETRYHI NKTVDGSTFS
810 820 830 840 850
VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN PVSPEDQVSL
860 870 880 890 900
AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR
910 920 930 940 950
KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC
960 970 980 990 1000
TAGNGNSDSN LTTYSRPADC IANYNNQLDN KQTNLMLPES TVYGDVDLSN
1010 1020 1030 1040 1050
KINEMKTFNS PNLKDGRFVN PSGQPTPYAT TQLIQSNLSN NMNNGSGDSG
1060 1070 1080 1090 1100
EKHWKPLGQQ KQEVAPVQYN IVEQNKLNKD YRANDTVPPT IPYNQSYDQN
1110 1120 1130 1140 1150
TGGSYNSSDR GSSTSGSQGH KKGGARTPKV PKQGGMNWAD LLPPPPAHPP
1160 1170 1180 1190 1200
PHSNSEEYNI SVDESYDQEM PCPVPPARMY LQQDELEEEE DERGPTPPVR
1210 1220 1230 1240 1250
GAASSPAAVS YSHQSTATLT PSPQEELQPM LQDCPEETGH MQHQPDRRRQ
1260 1270 1280 1290 1300
PVSPPPPPRP ISPPHTYGYI SGPLVSDMDT DAPEEEEDEA DMEVAKMQTR
1310 1320 1330 1340 1350
RLLLRGLEQT PASSVGDLES SVTGSMINGW GSASEEDNIS SGRSSVSSSD
1360 1370 1380 1390 1400
GSFFTDADFA QAVAAAAEYA GLKVARRQMQ DAAGRRHFHA SQCPRPTSPV
1410 1420 1430 1440 1450
STDSNMSAAV MQKTRPAKKL KHQPGHLRRE TYTDDLPPPP VPPPAIKSPT
1460 1470 1480 1490 1500
AQSKTQLEVR PVVVPKLPSM DARTDRSSDR KGSSYKGREV LDGRQVVDMR
1510 1520 1530 1540 1550
TNPGDPREAQ EQQNDGKGRG NKAAKRDLPP AKTHLIQEDI LPYCRPTFPT
1560 1570 1580 1590 1600
SNNPRDPSSS SSMSSRGSGS RQREQANVGR RNIAEMQVLG GYERGEDNNE

ELEETES
Length:1,607
Mass (Da):175,893
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19F15DB1F218810B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC112336 mRNA Translation: AAI12337.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112336 mRNA Translation: AAI12337.1

3D structure databases

SMRiQ2M1J3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ2M1J3, 1 interactor

Proteomic databases

PeptideAtlasiQ2M1J3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ROBO1, human

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR032986, Robo1
PANTHERiPTHR12231:SF243, PTHR12231:SF243, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 2 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2M1J3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M1J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 7, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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