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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi384 – 391ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:SYNAS_22440
ORF Names:SYN_01564
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei150 – 170HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei286 – 306HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716601 – 601Lipid A export ATP-binding/permease protein MsbAAdd BLAST601

Proteomic databases

PRIDEiQ2LVL0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_01564

Structurei

3D structure databases

ProteinModelPortaliQ2LVL0
SMRiQ2LVL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 318ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini352 – 585ABC transporterUniRule annotationAdd BLAST234

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiGDLMNRI
OrthoDBiPOG091H00DB

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2LVL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNRGCKPR RFEGNQRMDI FKRLLKLARP HAPRFAVAMV CMLIAGALTS
60 70 80 90 100
SLAFLVKPAL DDIFLDRNAE MLKWIPLAII LIYLVKGGCS YFQAILMSFI
110 120 130 140 150
GQRIVADLRN RLYEQIQKQS LSFFSKNPTG VLMSRITNDV NSIQGTVSDA
160 170 180 190 200
VTSLMKDSFT LICLVFVIFY RDWQLAIIAM IVFPLTIYPI AKFGQKMRSV
210 220 230 240 250
ATRTQVTMGS LTTLLQETIS GTRIVRAFCM EAHENQRFAR ENEKLMHLAL
260 270 280 290 300
KSVSINALSS PFMEFLGGIG IAAIIFYGGY QVIKGSSTPG TFFSFLTALI
310 320 330 340 350
MLYEPVKRLT NVNNTIQQGI AGAQRVFSII DLVPDIVDRD EAVELPRISE
360 370 380 390 400
KIEIRNISFA YDDTPVLRNI NLTIRAGEVV AFVGMSGGGK TTLVNLIPRF
410 420 430 440 450
YDVTAGQILI DGHDIRDVSL ISLRRQIGIV TQQTILFNDT VRNNIAYGSQ
460 470 480 490 500
GCSEKEIIEA ARAANAHDFI VNLPEGYDTV IGELGTKLSG GERQRISIAR
510 520 530 540 550
ALLKNAPILI LDEATSSLDT EAEMEVQEAL ERLMKGRTTL VIAHRLSTIR
560 570 580 590 600
NADRIVVLVK GEIVEEGAHE TLLARRGEYY KLHQLQFKED KVGEEVGRND

S
Length:601
Mass (Da):66,909
Last modified:February 21, 2006 - v1
Checksum:i68D656D9AEBBC23D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA Translation: ABC78123.1

Genome annotation databases

EnsemblBacteriaiABC78123; ABC78123; SYN_01564
KEGGisat:SYN_01564

Similar proteinsi

Entry informationi

Entry nameiMSBA_SYNAS
AccessioniPrimary (citable) accession number: Q2LVL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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