UniProtKB - Q2LGB3 (IRAK1_BOVIN)
Interleukin-1 receptor-associated kinase 1
IRAK1
Functioni
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 239 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 340 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 358 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 218 – 226 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 342 – 345 | ATPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- activation of NF-kappaB-inducing kinase activity Source: Ensembl
- cellular response to lipopolysaccharide Source: GO_Central
- cytokine-mediated signaling pathway Source: GO_Central
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: GO_Central
- intracellular signal transduction Source: GO_Central
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: Ensembl
- positive regulation of MAP kinase activity Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: GO_Central
- positive regulation of type I interferon production Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of cytokine-mediated signaling pathway Source: Ensembl
- toll-like receptor 2 signaling pathway Source: GO_Central
- toll-like receptor 4 signaling pathway Source: GO_Central
- type I interferon signaling pathway Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Immunity, Innate immunity |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:IRAK1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:30264, IRAK1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
- Lipid droplet By similarity
Note: Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity).By similarity
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- lipid droplet Source: UniProtKB
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269708 | 1 – 718 | Interleukin-1 receptor-associated kinase 1Add BLAST | 718 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | Phosphothreonine; by PKC/PRKCIBy similarity | 1 | |
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 180 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 209 | Phosphothreonine; by IRAK4By similarity | 1 | |
Modified residuei | 375 | PhosphoserineBy similarity | 1 | |
Modified residuei | 387 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 556 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q2LGB3 |
PRIDEi | Q2LGB3 |
Interactioni
Subunit structurei
Homodimer (By similarity).
Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (By similarity). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (By similarity). The TRAF6-PELI1-IRAK1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (By similarity). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (By similarity).
Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (By similarity).
Interacts with IL1RL1 (By similarity).
Interacts (when polyubiquitinated) with IKBKG/NEMO (By similarity).
Interacts with RSAD2/viperin (By similarity).
Interacts with IRAK1BP1 (By similarity).
Interacts with PELI2 (By similarity).
Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity).
Interacts with IRAK4 (By similarity).
Interacts with PELI3 (By similarity).
Interacts with PELI1 and TRAF6 (By similarity).
Interacts with INAVA; the interaction takes place upon PRR stimulation (By similarity).
Interacts (via C-terminus) with NFATC4 (via N-terminus) (By similarity).
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021407 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 106 | DeathAdd BLAST | 80 | |
Domaini | 212 – 521 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 310 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 211 | ProST regionBy similarityAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 194 | Pro-richAdd BLAST | 91 | |
Compositional biasi | 693 – 696 | Poly-Ser | 4 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
InParanoidi | Q2LGB3 |
OrthoDBi | 684563at2759 |
Family and domain databases
CDDi | cd08794, Death_IRAK1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035533, Death_IRAK1 IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAGGPGPGDP AVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
60 70 80 90 100
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVRILTHL QLLRARDIIT
110 120 130 140 150
AWHPPAPLLP PSTTSLTPSS ISAPSEAAVP GHRKLPSLAS TFLSPAFPGS
160 170 180 190 200
QTHSDPELCP GPSPAAHQPP LPSPAPSSTK PSPESPMSLL PGAPSSSFCW
210 220 230 240 250
PLHEICQGTH DFSEELKIGE GGFGCVYRAV MRNTVYAVKR LKEEADLEWT
260 270 280 290 300
TVKQSFQTEV QQLSRFRHPN IVDFAGYCAQ SGFYCLVYGF LPNGSLEDRL
310 320 330 340 350
HVQTQAWPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD VKSSNVLLDE
360 370 380 390 400
RLMPKLGDFG LARLSRFTGA NPGQSSSVAR TRTVRGTLAY LPEEYVKTGR
410 420 430 440 450
LAVDTDTFSF GVVLLETLAG QRAVRMHGAQ PKYLKDLVEE EAEEAGVTLK
460 470 480 490 500
GTQTAVQGGP AADTWAALVA AQIYKKHLDP RPGPCPPQLG LALGQLACCC
510 520 530 540 550
LHRRAKRRPP MTQVYQTLEE LQVVVAGPCL ELEAASRSPP SPQENSYVST
560 570 580 590 600
SGSALSRASP WQPLAAPLGA QAQATDWPQK GANQPVESDE SVSDLSAALH
610 620 630 640 650
SWHLSPSCPA GPGAPSWVPA PFGQAACTQG GAARESSCGS GPGLQPTAVE
660 670 680 690 700
GPLLGSSMSS RPPQIVINPA RRKMLQKLAL YEDGVLDSLQ LLSSSSLPDS
710
GQDLQDRQGP EERDEFRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ319075 mRNA Translation: ABC47878.2 |
RefSeqi | NP_001035645.1, NM_001040555.1 |
Genome annotation databases
Ensembli | ENSBTAT00000021407; ENSBTAP00000021407; ENSBTAG00000016085 |
GeneIDi | 533953 |
KEGGi | bta:533953 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ319075 mRNA Translation: ABC47878.2 |
RefSeqi | NP_001035645.1, NM_001040555.1 |
3D structure databases
SMRi | Q2LGB3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021407 |
Proteomic databases
PaxDbi | Q2LGB3 |
PRIDEi | Q2LGB3 |
Genome annotation databases
Ensembli | ENSBTAT00000021407; ENSBTAP00000021407; ENSBTAG00000016085 |
GeneIDi | 533953 |
KEGGi | bta:533953 |
Organism-specific databases
CTDi | 3654 |
VGNCi | VGNC:30264, IRAK1 |
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
InParanoidi | Q2LGB3 |
OrthoDBi | 684563at2759 |
Gene expression databases
ExpressionAtlasi | Q2LGB3, baseline and differential |
Family and domain databases
CDDi | cd08794, Death_IRAK1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035533, Death_IRAK1 IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IRAK1_BOVIN | |
Accessioni | Q2LGB3Primary (citable) accession number: Q2LGB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | March 21, 2006 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families