UniProtKB - Q2LC84 (NUMB_RAT)
Protein numb homolog
Numb
Functioni
GO - Molecular functioni
- alpha-catenin binding Source: RGD
- beta-catenin binding Source: RGD
- cadherin binding Source: RGD
GO - Biological processi
- adherens junction organization Source: RGD
- axonogenesis Source: RGD
- cell differentiation Source: RGD
- cell population proliferation Source: RGD
- forebrain development Source: RGD
- lateral ventricle development Source: RGD
- lung epithelial cell differentiation Source: RGD
- negative regulation of Notch signaling pathway Source: RGD
- negative regulation of protein localization to plasma membrane Source: RGD
- nervous system development Source: RGD
- neuroblast division in subventricular zone Source: RGD
- neuroblast proliferation Source: RGD
- positive regulation of cell migration Source: RGD
- positive regulation of dendrite morphogenesis Source: RGD
- positive regulation of neurogenesis Source: RGD
- positive regulation of polarized epithelial cell differentiation Source: RGD
- regulation of neuron differentiation Source: RGD
- regulation of postsynaptic neurotransmitter receptor internalization Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Enzyme and pathway databases
Reactomei | R-RNO-437239, Recycling pathway of L1 R-RNO-5610780, Degradation of GLI1 by the proteasome R-RNO-5632684, Hedgehog 'on' state |
Names & Taxonomyi
Protein namesi | Recommended name: Protein numb homolog |
Gene namesi | Name:Numb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620107, Numb |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Endosome
- Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Localizes to perinuclear endosomes in an AAK1-dependent manner.By similarity
Endosome
- early endosome Source: RGD
- endosome membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: RGD
Plasma Membrane
- basolateral plasma membrane Source: RGD
- clathrin-coated pit Source: RGD
- extrinsic component of plasma membrane Source: RGD
Other locations
- apical part of cell Source: RGD
- clathrin-coated vesicle Source: RGD
- cytoplasm Source: RGD
- cytoplasmic vesicle Source: RGD
- glutamatergic synapse Source: RGD
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 275 | S → A: Loss of phosphorylation by CaMK1. 1 Publication | 1 | |
Mutagenesisi | 294 | S → A: Loss of phosphorylation by CaMK1. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412901 | 1 – 652 | Protein numb homologAdd BLAST | 652 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 102 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineBy similarity | 1 | |
Modified residuei | 242 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 243 | PhosphoserineBy similarity | 1 | |
Modified residuei | 275 | Phosphoserine; by CaMK11 Publication | 1 | |
Modified residuei | 294 | Phosphoserine; by CaMK11 Publication | 1 | |
Modified residuei | 426 | PhosphoserineBy similarity | 1 | |
Modified residuei | 437 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineCombined sources | 1 | |
Modified residuei | 635 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PRIDEi | Q2LC84 |
PTM databases
iPTMneti | Q2LC84 |
PhosphoSitePlusi | Q2LC84 |
Interactioni
Subunit structurei
Interacts with SIAH1 (By similarity).
Interacts with LNX (By similarity).
Interacts with CDH1 (By similarity).
Interacts with TFAP2A and TFAP2B (PubMed:17022975).
Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (By similarity).
Interacts with AAK1 (By similarity). May interact with DUOXA1 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- alpha-catenin binding Source: RGD
- beta-catenin binding Source: RGD
- cadherin binding Source: RGD
Protein-protein interaction databases
IntActi | Q2LC84, 20 interactors |
MINTi | Q2LC84 |
STRINGi | 10116.ENSRNOP00000048410 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 173 | PIDPROSITE-ProRule annotationAdd BLAST | 137 |
Phylogenomic databases
eggNOGi | KOG3537, Eukaryota |
InParanoidi | Q2LC84 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016698, Numb/numb-like IPR010449, Numb_domain IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF06311, NumbF, 1 hit PF00640, PID, 1 hit |
PIRSFi | PIRSF017607, Numb/numb-like, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD
60 70 80 90 100
ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE
110 120 130 140 150
KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT
160 170 180 190 200
GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA
210 220 230 240 250
TEQAEREEIM KQLQDAKKAE TDKTVGPSVA PGNSAPSPSS PTSPTLDPTA
260 270 280 290 300
SLEMNNPHAI PRRHAPIEQL ARQGSFRGFP ALSQKMSPFK RQLSLRINEL
310 320 330 340 350
PSTMQRKTDF PIKNTVPEVE GEAESISSLC SQITSAFSTP CEDPFSSAPM
360 370 380 390 400
TKPVTLVAPQ SPVLQANGTD SALHVLTAKP ASTALAPVAM PVRETNPWAH
410 420 430 440 450
APDAANKEIA AIHSGTEWGQ SSGAASPGLF QAGHRRTPSE ADRWLEEVSK
460 470 480 490 500
SVRAQQPQAS AAPLQPVLQP PPPAAIAPPA PPFQGHAFLT SQPVPVGVVP
510 520 530 540 550
PLQPAFVSTQ SYPVANGMPY PASNVPVVGI TPSQMVANVF GTAGHPQATH
560 570 580 590 600
PHQSPSLAKQ QTFPQYETSS ATTSPFFKPS AQHLNGSAAF NGVDNSGLVS
610 620 630 640 650
GNRPAQVPPG TCPVDPFEAQ WAALESKPKQ RTNPSPTNPF SSDAQKAFEI
EL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LNZ2 | F1LNZ2_RAT | Protein numb homolog | Numb | 653 | Annotation score: | ||
H9KVE4 | H9KVE4_RAT | Protein numb homolog | Numb | 604 | Annotation score: | ||
F1LRS4 | F1LRS4_RAT | Protein numb homolog | Numb | 642 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 459 | A → V in ABC69737 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041811 | 68 – 78 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC166596 mRNA Translation: AAI66596.1 DQ336705 mRNA Translation: ABC69737.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC166596 mRNA Translation: AAI66596.1 DQ336705 mRNA Translation: ABC69737.1 |
3D structure databases
SMRi | Q2LC84 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q2LC84, 20 interactors |
MINTi | Q2LC84 |
STRINGi | 10116.ENSRNOP00000048410 |
PTM databases
iPTMneti | Q2LC84 |
PhosphoSitePlusi | Q2LC84 |
Proteomic databases
PRIDEi | Q2LC84 |
Organism-specific databases
RGDi | 620107, Numb |
Phylogenomic databases
eggNOGi | KOG3537, Eukaryota |
InParanoidi | Q2LC84 |
Enzyme and pathway databases
Reactomei | R-RNO-437239, Recycling pathway of L1 R-RNO-5610780, Degradation of GLI1 by the proteasome R-RNO-5632684, Hedgehog 'on' state |
Miscellaneous databases
PROi | PR:Q2LC84 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016698, Numb/numb-like IPR010449, Numb_domain IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
Pfami | View protein in Pfam PF06311, NumbF, 1 hit PF00640, PID, 1 hit |
PIRSFi | PIRSF017607, Numb/numb-like, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUMB_RAT | |
Accessioni | Q2LC84Primary (citable) accession number: Q2LC84 Secondary accession number(s): B2GVA9, F1MAI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |