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Protein
Submitted name:

Tumor necrosis factor alpha

Gene
N/A
Organism
Diceros bicornis (Black rhinoceros)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
OrganismiDiceros bicornis (Black rhinoceros)Imported
Taxonomic identifieri9805 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaRhinocerotidaeDiceros

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 55HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ2LAH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 233TNF_2InterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012516

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2LAH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEELARK AGGPQSSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EELPNGFPFN NPLAQTLRSS SRNPSDKPVA HVVANPQAEG
110 120 130 140 150
QLQWLSGRAN ALLANGVELT DNQLVVPVDG LYLIYSQVLF RGQGCSSTHV
160 170 180 190 200
LLTHTISRFA VSYQTKVNLL SAIKSPCQTE TPEGAEAKPW YEPIYLGGVF
210 220 230
KLEKGDRLSA EINLPDYLDF AESGQVYFGI IAL
Length:233
Mass (Da):25,460
Last modified:February 21, 2006 - v1
Checksum:iC42BD327A3804BC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ340435 mRNA Translation: ABC68489.1

Similar proteinsi

Entry informationi

Entry nameiQ2LAH3_DICBI
AccessioniPrimary (citable) accession number: Q2LAH3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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