UniProtKB - Q2L6J1 (Q2L6J1_HUMAN)
Protein
RING-type E3 ubiquitin transferase
Gene
TRIM31
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
GO - Molecular functioni
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TRIM31Imported ORF Names:DASS-211F20.2-001Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204616.10 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues |
Interactioni
Binary interactionsi
Hide detailsQ2L6J1
With | #Exp. | IntAct |
---|---|---|
MAGEA1 [P43355] | 3 | EBI-10239267,EBI-740978 |
MAGEA2B [Q96E03] | 3 | EBI-10239267,EBI-10239285 |
Protein-protein interaction databases
IntActi | Q2L6J1, 2 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 57 | RING-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 90 – 131 | B box-typeInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 328 – 360 | DisorderedSequence analysisAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 135 – 155 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_013137_6_1_1 |
OMAi | YFCEQDG |
OrthoDBi | 661340at2759 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000315, Znf_B-box IPR020457, Znf_B-box_chordata IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit |
PRINTSi | PR01406, BBOXZNFINGER |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2L6J1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF
60 70 80 90 100
FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE
110 120 130 140 150
MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ
160 170 180 190 200
QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL
210 220 230 240 250
SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI
260 270 280 290 300
KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD
310 320 330 340 350
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP
360 370 380 390 400
NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL
410 420
SEELHAALSE WLTAIRAWFC EVPSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500700 Genomic DNA Translation: AQY77172.1 KY500701 Genomic DNA Translation: AQY77173.1 KY500705 Genomic DNA Translation: AQY77177.2 KY500706 Genomic DNA Translation: AQY77178.1 KY500710 Genomic DNA Translation: AQY77181.1 KY500711 Genomic DNA Translation: AQY77182.1 KY500715 Genomic DNA Translation: AQY77185.1 AB202083 Genomic DNA Translation: BAE78603.1 AK290270 mRNA Translation: BAF82959.1 BX897730, BX005441, BX088647 Genomic DNA Translation: CAM26290.1 |
RefSeqi | NP_008959.3, NM_007028.4 |
Genome annotation databases
GeneIDi | 11074 |
KEGGi | hsa:11074 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500700 Genomic DNA Translation: AQY77172.1 KY500701 Genomic DNA Translation: AQY77173.1 KY500705 Genomic DNA Translation: AQY77177.2 KY500706 Genomic DNA Translation: AQY77178.1 KY500710 Genomic DNA Translation: AQY77181.1 KY500711 Genomic DNA Translation: AQY77182.1 KY500715 Genomic DNA Translation: AQY77185.1 AB202083 Genomic DNA Translation: BAE78603.1 AK290270 mRNA Translation: BAF82959.1 BX897730, BX005441, BX088647 Genomic DNA Translation: CAM26290.1 |
RefSeqi | NP_008959.3, NM_007028.4 |
3D structure databases
SMRi | Q2L6J1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q2L6J1, 2 interactors |
Protocols and materials databases
Antibodypediai | 11702, 179 antibodies |
DNASUi | 11074 |
Genome annotation databases
GeneIDi | 11074 |
KEGGi | hsa:11074 |
Organism-specific databases
CTDi | 11074 |
EuPathDBi | HostDB:ENSG00000204616.10 |
PharmGKBi | PA38117 |
Phylogenomic databases
HOGENOMi | CLU_013137_6_1_1 |
OMAi | YFCEQDG |
OrthoDBi | 661340at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11074, 2 hits in 843 CRISPR screens |
ChiTaRSi | TRIM31, human |
GenomeRNAii | 11074 |
Gene expression databases
Bgeei | ENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000315, Znf_B-box IPR020457, Znf_B-box_chordata IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit |
PRINTSi | PR01406, BBOXZNFINGER |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2L6J1_HUMAN | |
Accessioni | Q2L6J1Primary (citable) accession number: Q2L6J1 Secondary accession number(s): A0A1U9X8Q7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 7, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |