UniProtKB - Q2L6I2 (Q2L6I2_HUMAN)
Protein
Submitted name:
ABC50 protein
Gene
ABCF1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 298 – 305 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 620 – 627 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationImportedARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ABC50 proteinImportedSubmitted name: ATP-binding cassette, sub-family F (GCN20), member 1ImportedSubmitted name: ATP-binding cassette, sub-family F (GCN20), member 1, isoform CRA_aImported |
Gene namesi | Name:ABCF1Imported Synonyms:ABC50Imported ORF Names:hCG_26012Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204574.12 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000204574, Expressed in sural nerve and 233 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 266 – 510 | ABC transporterInterPro annotationAdd BLAST | 245 | |
Domaini | 587 – 802 | ABC transporterInterPro annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 221 | DisorderedSequence analysisAdd BLAST | 221 | |
Regioni | 521 – 564 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 63 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 83 – 121 | PolyampholyteSequence analysisAdd BLAST | 39 | |
Compositional biasi | 145 – 198 | PolyampholyteSequence analysisAdd BLAST | 54 | |
Compositional biasi | 207 – 221 | PolyampholyteSequence analysisAdd BLAST | 15 |
Phylogenomic databases
HOGENOMi | CLU_000604_36_5_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q2L6I2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK
60 70 80 90 100
QAGEEEKVLK EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER
110 120 130 140 150
LKKLSVPTSD EEDEVPAPKP RGGKKTKGGN VFAALIQDQS EEEEEEEKHP
160 170 180 190 200
PKPAKPEKNR INKAVSEEQQ PALKGKKGKE EKSKGKAKPQ NKFAALDNEE
210 220 230 240 250
EDKEEEIIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN AAENDFSVSQ
260 270 280 290 300
AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN
310 320 330 340 350
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL
360 370 380 390 400
KLLEEERRLQ GQLEQGDDTA AERLEKVYEE LRATGAAAAE AKARRILAGL
410 420 430 440 450
GFDPEMQNRP TQKFSGGWRM RVSLARALFM EPTLLMLDEP TNHLDLNAVI
460 470 480 490 500
WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI IHLDAQRLHY YRGNYMTFKK
510 520 530 540 550
MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA LTRKQQKCRR
560 570 580 590 600
KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYQGQK
610 620 630 640 650
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT HGEMRKNHRL
660 670 680 690 700
KIGFFNQQYA EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI
710 720 730 740 750
QICKLSGGQK ARVVFAELAC REPDVLILDE PTNNLDIESI DALGEAINEY
760 770 780 790 800
KGAVIVVSHD ARLITETNCQ LWVVEEQSVS QIDGDFEDYK REVLEALGEV
MVSRPRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB202093 Genomic DNA Translation: BAE78612.1 AB103602 Genomic DNA Translation: BAF31263.1 CH471081 Genomic DNA Translation: EAX03300.1 CH471081 Genomic DNA Translation: EAX03301.1 |
RefSeqi | NP_001081.1, NM_001090.2 |
Genome annotation databases
GeneIDi | 23 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB202093 Genomic DNA Translation: BAE78612.1 AB103602 Genomic DNA Translation: BAF31263.1 CH471081 Genomic DNA Translation: EAX03300.1 CH471081 Genomic DNA Translation: EAX03301.1 |
RefSeqi | NP_001081.1, NM_001090.2 |
3D structure databases
SMRi | Q2L6I2 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q2L6I2 |
Protocols and materials databases
Antibodypediai | 2796, 285 antibodies |
DNASUi | 23 |
Genome annotation databases
GeneIDi | 23 |
Organism-specific databases
CTDi | 23 |
EuPathDBi | HostDB:ENSG00000204574.12 |
PharmGKBi | PA24405 |
Phylogenomic databases
HOGENOMi | CLU_000604_36_5_1 |
Miscellaneous databases
BioGRID-ORCSi | 23, 652 hits in 855 CRISPR screens |
ChiTaRSi | ABCF1, human |
GenomeRNAii | 23 |
Gene expression databases
Bgeei | ENSG00000204574, Expressed in sural nerve and 233 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2L6I2_HUMAN | |
Accessioni | Q2L6I2Primary (citable) accession number: Q2L6I2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 7, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |