UniProtKB - Q2L6I0 (Q2L6I0_HUMAN)
Protein
MHC class I region proline-rich protein CAT53
Gene
PPP1R10
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 906 – 934 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein phosphatase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protein phosphatase inhibitorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: MHC class I region proline-rich protein CAT53ARBA annotationAlternative name(s): Serine/threonine-protein phosphatase 1 regulatory subunit 10ARBA annotation |
Gene namesi | Name:PPP1R10Imported Synonyms:FB19Imported ORF Names:hCG_26006Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204569.9 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Other locations
- chromatin Source: Ensembl
- PTW/PP1 phosphatase complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, MethylationARBA annotation, Ubl conjugationARBA annotationProteomic databases
PRIDEi | Q2L6I0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204569, Expressed in sural nerve and 225 other tissues |
ExpressionAtlasi | Q2L6I0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 147 | TFIIS N-terminalInterPro annotationAdd BLAST | 75 | |
Domaini | 906 – 934 | C3H1-typeInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 210 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 248 – 270 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 304 – 400 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 533 – 580 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 617 – 905 | DisorderedSequence analysisAdd BLAST | 289 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 151 – 200 | PolyampholyteSequence analysisAdd BLAST | 50 | |
Compositional biasi | 320 – 334 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 627 – 679 | Pro-richSequence analysisAdd BLAST | 53 | |
Compositional biasi | 850 – 903 | PolyampholyteSequence analysisAdd BLAST | 54 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 906 – 934 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_019410_0_0_1 |
OMAi | DHGRGHP |
OrthoDBi | 999354at2759 |
Family and domain databases
Gene3Di | 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF08711, Med26, 1 hit PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00509, TFS2N, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS51319, TFIIS_N, 1 hit PS50103, ZF_C3H1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2L6I0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY
60 70 80 90 100
LNILLQTRSP EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH
110 120 130 140 150
LPLTVDHLKQ NNTAKLVKQL SKSSEDEELR KLASVLVSDW MAVIRSQSST
160 170 180 190 200
QPAEKDKKKR KDEGKSRTTL PERPLTEVKA ETRAEEAPEK KREKPKSLRT
210 220 230 240 250
TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP IPLKRQSNVA
260 270 280 290 300
APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV
310 320 330 340 350
PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD
360 370 380 390 400
RPGTPVPPVE VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT
410 420 430 440 450
WPEEGKLREY FYFELDETER VNVNKIKDFG EAAKREILSD RHAFETARRL
460 470 480 490 500
SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS QERYIQAERE KGILQELFLN
510 520 530 540 550
KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG GSGGSPDGAG
560 570 580 590 600
GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL
610 620 630 640 650
LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP
660 670 680 690 700
MPGPHGGPGG PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP
710 720 730 740 750
GPYHRGRGGR GGNEPPPPPP PFRGARGGRS GGGPPNGRGG PGGGMVGGGG
760 770 780 790 800
HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG HRPHEGPGGS MGGGGGHRPH
810 820 830 840 850
EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG GSGGHRPHEG
860 870 880 890 900
PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH
910 920 930 940
SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC136294 mRNA Translation: AAI36295.1 HM005690 mRNA Translation: AEE61287.1 KY500561 Genomic DNA Translation: AQY77033.1 KY500562 Genomic DNA Translation: AQY77034.1 KY500563 Genomic DNA Translation: AQY77035.1 KY500564 Genomic DNA Translation: AQY77036.2 KY500565 Genomic DNA Translation: AQY77037.1 KY500566 Genomic DNA Translation: AQY77038.1 KY500567 Genomic DNA Translation: AQY77039.1 AB202094 Genomic DNA Translation: BAE78613.1 AB103603 Genomic DNA Translation: BAF31264.1 CH471081 Genomic DNA Translation: EAX03303.1 |
RefSeqi | NP_002705.2, NM_002714.3 XP_006715193.1, XM_006715130.2 XP_011513024.1, XM_011514722.1 XP_016866484.1, XM_017010995.1 |
Genome annotation databases
GeneIDi | 5514 |
KEGGi | hsa:5514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC136294 mRNA Translation: AAI36295.1 HM005690 mRNA Translation: AEE61287.1 KY500561 Genomic DNA Translation: AQY77033.1 KY500562 Genomic DNA Translation: AQY77034.1 KY500563 Genomic DNA Translation: AQY77035.1 KY500564 Genomic DNA Translation: AQY77036.2 KY500565 Genomic DNA Translation: AQY77037.1 KY500566 Genomic DNA Translation: AQY77038.1 KY500567 Genomic DNA Translation: AQY77039.1 AB202094 Genomic DNA Translation: BAE78613.1 AB103603 Genomic DNA Translation: BAF31264.1 CH471081 Genomic DNA Translation: EAX03303.1 |
RefSeqi | NP_002705.2, NM_002714.3 XP_006715193.1, XM_006715130.2 XP_011513024.1, XM_011514722.1 XP_016866484.1, XM_017010995.1 |
3D structure databases
SMRi | Q2L6I0 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q2L6I0 |
Protocols and materials databases
Antibodypediai | 26382, 135 antibodies |
Genome annotation databases
GeneIDi | 5514 |
KEGGi | hsa:5514 |
Organism-specific databases
CTDi | 5514 |
EuPathDBi | HostDB:ENSG00000204569.9 |
PharmGKBi | PA33612 |
Phylogenomic databases
HOGENOMi | CLU_019410_0_0_1 |
OMAi | DHGRGHP |
OrthoDBi | 999354at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5514, 653 hits in 853 CRISPR screens |
ChiTaRSi | PPP1R10, human |
GenomeRNAii | 5514 |
Gene expression databases
Bgeei | ENSG00000204569, Expressed in sural nerve and 225 other tissues |
ExpressionAtlasi | Q2L6I0, baseline and differential |
Family and domain databases
Gene3Di | 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF08711, Med26, 1 hit PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00509, TFS2N, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS51319, TFIIS_N, 1 hit PS50103, ZF_C3H1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2L6I0_HUMAN | |
Accessioni | Q2L6I0Primary (citable) accession number: Q2L6I0 Secondary accession number(s): A0A1U9X8C5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 7, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |