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Protein

Cytospin-A

Gene

specc1la

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).By similarity

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • face morphogenesis Source: MGI

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
SPECC1-like protein
Sperm antigen with calponin homology and coiled-coil domains 1-like
Gene namesi
Name:specc1la
Synonyms:cytsa, cytsaa, specc1l
ORF Names:im:7159316, si:dkey-118g10.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-060810-139 specc1la

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002310231 – 1132Cytospin-AAdd BLAST1132

Proteomic databases

PaxDbiQ2KN93
PRIDEiQ2KN93

Expressioni

Gene expression databases

BgeeiENSDARG00000006719 Expressed in 18 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ2KN93 baseline

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010292

Structurei

3D structure databases

ProteinModelPortaliQ2KN93
SMRiQ2KN93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1026 – 1131Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili226 – 268Sequence analysisAdd BLAST43
Coiled coili385 – 440Sequence analysisAdd BLAST56
Coiled coili478 – 798Sequence analysisAdd BLAST321

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 211Poly-Glu7
Compositional biasi322 – 383Ser-richAdd BLAST62
Compositional biasi848 – 865Ala-richAdd BLAST18
Compositional biasi992 – 996Poly-Ser5

Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000015307
HOVERGENiHBG056096
InParanoidiQ2KN93
OMAiERPDWQN
PhylomeDBiQ2KN93
TreeFamiTF316716

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q2KN93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKAGRPVGN KAASGGGKGD SVTAGNCAGK NTVKSPTSAP LSKVKSNDDL
60 70 80 90 100
LAAMAGSSAG TNNSVAKGKK STSTHSTSCG TNTNNPDTKT KTTSGPSGKR
110 120 130 140 150
TTSMTSKESN SSRERLRNSR NSSSKKQSST GASDRAQPKH SRALAQTSDS
160 170 180 190 200
ESRMSKSKSD GQLSDKVALE AKVKNLLGLA KSKDVEILQL RGELRDMRVQ
210 220 230 240 250
LGLPEEDEEE ERPPEREAAA VITAADVEST LLLLQEQNQA IRGELNLLKN
260 270 280 290 300
ENRMLKDRLN ALGFSLEQRL DGADKTFGFP STSPELSSGG AGAHGDCATV
310 320 330 340 350
ASSVEGSAPG SMEDLLTGGQ RSGSTDNLDS ESSEVYQAVT SSDDALDAPS
360 370 380 390 400
GCGSSSSSES EGGPPACRSS SRKGSSGNTS EVSVACLTER IHQMEENQHS
410 420 430 440 450
TSEELQATLQ ELADLQQITQ ELNGENERLG EEKVLLMDSL CQQSDKLEHC
460 470 480 490 500
GRQIEYFRSL LDEHGVAYSV DEDIKSGRYM ELEQRYVELA ENARFEREQL
510 520 530 540 550
LGVQQHLSNT LKMAEQDNAE AQNVIAALKE RNHHMERLLD VERQERASMA
560 570 580 590 600
AVLEECKAAV NNDQAELSRC RVLLEQERQK VAELYSIHNA GDKSDIHQLL
610 620 630 640 650
EGVRLDKEEA EAKASKLQDD LGHARSEVAC LQDTLNKLDA EYRDFQSVVQ
660 670 680 690 700
KELAEQKRAI EKQREDLQEK ETEIGDMKET IFELEDEVEQ HRAVKLHDNL
710 720 730 740 750
IISDLENSMK KLQDQKHDME REIKILHRRL REESAEWRQF QADLQTAVVI
760 770 780 790 800
ANDIKSEAQE EIGDLRRRLQ EAQEKNEKLG KEIEEVKNRK QDEERGRVYN
810 820 830 840 850
YMNAVERDLA ALRQGMGLSR RPSTSSEPSP TVKTLIKSFD SASQGPGANA
860 870 880 890 900
TAVAAAAAAA AAAAAVTVTS TTPTAPLPRT PLSPSPMKTP PAAAVSPIQR
910 920 930 940 950
HSITGSMAAA KPLSSLADKR PSYTDISMPA EHLLRAANSR PASALQRVSN
960 970 980 990 1000
MDTSKTITVS RRSSEEPKRD ISTPDGGPAS SLISMSSAAA LSSSSSPTAS
1010 1020 1030 1040 1050
VNPTARSRLR EERKDPLSAL AREYGGSKRN ALLRWCQKKT EGYQNIDITN
1060 1070 1080 1090 1100
FSSSWNDGLA FCAVLHTYLP AHIPYQELNS QDKRRNFTLA FQAAESVGIK
1110 1120 1130
STLDITDMVH TERPDWQSVM TYVTSIYKYF ET
Length:1,132
Mass (Da):123,627
Last modified:February 10, 2009 - v2
Checksum:iD981C97E55FFF321
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YBD4A0A286YBD4_DANRE
Cytospin-A
specc1la
1,132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40P → S in AAX84193 (Ref. 1) Curated1
Sequence conflicti1106T → N in AAX84193 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884302 mRNA Translation: AAX84193.1
CR547121 Genomic DNA Translation: CAQ15300.1
RefSeqiNP_001034905.1, NM_001039816.1
XP_005167234.1, XM_005167177.3
UniGeneiDr.79058

Genome annotation databases

EnsembliENSDART00000014046; ENSDARP00000010292; ENSDARG00000006719
ENSDART00000164976; ENSDARP00000135296; ENSDARG00000006719
GeneIDi561775
KEGGidre:561775

Similar proteinsi

Entry informationi

Entry nameiCYTSA_DANRE
AccessioniPrimary (citable) accession number: Q2KN93
Secondary accession number(s): B0UYP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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