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Protein

Phospholipase D3

Gene

PLD3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in APP processing.By similarity

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei201PROSITE-ProRule annotation1
Active sitei203PROSITE-ProRule annotation1
Active sitei208PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-2029485 Role of phospholipids in phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D3 (EC:3.1.4.4)
Short name:
PLD 3
Alternative name(s):
Choline phosphatase 3
Phosphatidylcholine-hydrolyzing phospholipase D3
Gene namesi
Name:PLD3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:32997 PLD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 490LumenalSequence analysisAdd BLAST431

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803251 – 490Phospholipase D3Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KJJ8
PRIDEiQ2KJJ8

Expressioni

Gene expression databases

BgeeiENSBTAG00000019150

Interactioni

Subunit structurei

Interacts with APP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041666

Structurei

3D structure databases

ProteinModelPortaliQ2KJJ8
SMRiQ2KJJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 223PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini411 – 437PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
HOVERGENiHBG052880
InParanoidiQ2KJJ8
KOiK16860
OMAiTHFIPNT
OrthoDBiEOG091G07LR
TreeFamiTF313378

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q2KJJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKLMYQEL KVPAEEPASE LPMNEIEAWK AAEKKARWVL LVLILAVVGF
60 70 80 90 100
GALMTQLFLW EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST
110 120 130 140 150
SNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEAS AQQGEEVLRQ
160 170 180 190 200
LQTLAPRGVK VRIAVSKPNG PQPQADLQAL LQSGAQVRMV DMQKLTHGVL
210 220 230 240 250
HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL ARDLTKIFEA
260 270 280 290 300
YWFLGQAGSS IPSTWPRPYD TRYNQETPME ICLNGTPALA YLASAPPPLC
310 320 330 340 350
PSGRTPDLKA LLNVVDNARS FIYIAVMNYL PIMEFSHPRR FWPAIDDGLR
360 370 380 390 400
RAAYERGVKV RLLISCWGHS DPSMRAFLLS LAALRDNHTH SDIQVKLFVV
410 420 430 440 450
PADDAQARIP YARVNHNKYM VTERATYIGT SNWSGSYFTE TAGTSLLVTQ
460 470 480 490
NGRGGLRSQL EAVFLRDWDS PYSHDLDAAA DSVGNACRLL
Length:490
Mass (Da):54,619
Last modified:March 7, 2006 - v1
Checksum:i8D5F78A548AD3BE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105309 mRNA Translation: AAI05310.1
RefSeqiNP_001071509.1, NM_001078041.2
XP_005219060.1, XM_005219003.3
XP_005219061.1, XM_005219004.3
XP_005219062.1, XM_005219005.2
UniGeneiBt.16204

Genome annotation databases

EnsembliENSBTAT00000044153; ENSBTAP00000041666; ENSBTAG00000019150
GeneIDi613932
KEGGibta:613932

Similar proteinsi

Entry informationi

Entry nameiPLD3_BOVIN
AccessioniPrimary (citable) accession number: Q2KJJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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