UniProtKB - Q2KJH6 (SERPH_BOVIN)
Protein
Serpin H1
Gene
SERPINH1
Organism
Bos taurus (Bovine)
Status
Functioni
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 377 – 378 | Reactive bond homologBy similarity | 2 |
GO - Molecular functioni
- collagen binding Source: InterPro
- serine-type endopeptidase inhibitor activity Source: GO_Central
- unfolded protein binding Source: Ensembl
GO - Biological processi
- chondrocyte development involved in endochondral bone morphogenesis Source: Ensembl
- collagen biosynthetic process Source: Ensembl
- collagen fibril organization Source: GO_Central
- negative regulation of endopeptidase activity Source: GO_Central
- protein maturation Source: Ensembl
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
Reactomei | R-BTA-1650814, Collagen biosynthesis and modifying enzymes |
Protein family/group databases
MEROPSi | I04.035 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin H1Alternative name(s): Collagen-binding protein Short name: Colligin |
Gene namesi | Name:SERPINH1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:34480, SERPINH1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: InterPro
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
- membrane raft Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000253604 | 19 – 418 | Serpin H1Add BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | N6-succinyllysineBy similarity | 1 | |
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 141 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 296 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 319 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q2KJH6 |
PeptideAtlasi | Q2KJH6 |
PRIDEi | Q2KJH6 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000001027, Expressed in placenta and 18 other tissues |
Interactioni
GO - Molecular functioni
- unfolded protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000039506 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 415 – 418 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 29 | Poly-Ala | 5 |
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000156163 |
HOGENOMi | CLU_023330_2_0_1 |
InParanoidi | Q2KJH6 |
OMAi | NMPLGQK |
OrthoDBi | 1124079at2759 |
TreeFami | TF343094 |
Family and domain databases
CDDi | cd02046, serpinH1_CBP1, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR033830, Serpin_H1_serpin_dom IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 IPR033547, SERPINH1 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF27, PTHR11461:SF27, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q2KJH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL
60 70 80 90 100
AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE
110 120 130 140 150
QLRDDEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS
160 170 180 190 200
KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL
210 220 230 240 250
VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK
260 270 280 290 300
EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK
310 320 330 340 350
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS
360 370 380 390 400
VFHATAFEWD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL
410
LFIGRLVRPK GDKMRDEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC105338 mRNA Translation: AAI05339.1 |
RefSeqi | NP_001039528.1, NM_001046063.1 XP_005216304.1, XM_005216247.2 XP_005216305.1, XM_005216248.3 |
Genome annotation databases
Ensembli | ENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027 ENSBTAT00000083385; ENSBTAP00000072322; ENSBTAG00000001027 |
GeneIDi | 510850 |
KEGGi | bta:510850 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC105338 mRNA Translation: AAI05339.1 |
RefSeqi | NP_001039528.1, NM_001046063.1 XP_005216304.1, XM_005216247.2 XP_005216305.1, XM_005216248.3 |
3D structure databases
SMRi | Q2KJH6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000039506 |
Protein family/group databases
MEROPSi | I04.035 |
Proteomic databases
PaxDbi | Q2KJH6 |
PeptideAtlasi | Q2KJH6 |
PRIDEi | Q2KJH6 |
Genome annotation databases
Ensembli | ENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027 ENSBTAT00000083385; ENSBTAP00000072322; ENSBTAG00000001027 |
GeneIDi | 510850 |
KEGGi | bta:510850 |
Organism-specific databases
CTDi | 871 |
VGNCi | VGNC:34480, SERPINH1 |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000156163 |
HOGENOMi | CLU_023330_2_0_1 |
InParanoidi | Q2KJH6 |
OMAi | NMPLGQK |
OrthoDBi | 1124079at2759 |
TreeFami | TF343094 |
Enzyme and pathway databases
Reactomei | R-BTA-1650814, Collagen biosynthesis and modifying enzymes |
Gene expression databases
Bgeei | ENSBTAG00000001027, Expressed in placenta and 18 other tissues |
Family and domain databases
CDDi | cd02046, serpinH1_CBP1, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR033830, Serpin_H1_serpin_dom IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 IPR033547, SERPINH1 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF27, PTHR11461:SF27, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SERPH_BOVIN | |
Accessioni | Q2KJH6Primary (citable) accession number: Q2KJH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families