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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

UBLCP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:UBLCP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:36609 UBLCP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002426392 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJD7
PRIDEiQ2KJD7

Expressioni

Gene expression databases

BgeeiENSBTAG00000009103 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011999

Structurei

3D structure databases

ProteinModelPortaliQ2KJD7
SMRiQ2KJD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
KOG1872 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000010107
HOGENOMiHOG000231279
HOVERGENiHBG080207
InParanoidiQ2KJD7
KOiK17618
OMAiFKLMMVG
OrthoDBiEOG091G0CRH
TreeFamiTF323786

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR011943 HAD-SF_hydro_IIID
IPR023214 HAD_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF03031 NIF, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02245 HAD_IIID1, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD
110 120 130 140 150
IEDEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF
310
LDLNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,805
Last modified:March 7, 2006 - v1
Checksum:i21CB4DB22C3B0E0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105394 mRNA Translation: AAI05395.1
RefSeqiNP_001039459.1, NM_001045994.1
XP_010805865.1, XM_010807563.2
UniGeneiBt.1089

Genome annotation databases

EnsembliENSBTAT00000011999; ENSBTAP00000011999; ENSBTAG00000009103
GeneIDi508163
KEGGibta:508163

Similar proteinsi

Entry informationi

Entry nameiUBCP1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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