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Protein

Transmembrane emp24 domain-containing protein 5

Gene

TMED5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 5
Alternative name(s):
p24 family protein gamma 2
Short name:
p24gamma2
Gene namesi
Name:TMED5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:35938 TMED5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 193LumenalSequence analysisAdd BLAST169
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 226CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000024034725 – 226Transmembrane emp24 domain-containing protein 5Add BLAST202

Proteomic databases

PaxDbiQ2KJ84
PRIDEiQ2KJ84

Expressioni

Gene expression databases

BgeeiENSBTAG00000020180

Interactioni

Subunit structurei

Interacts with TMED9 and TMED10.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032097

Structurei

3D structure databases

SMRiQ2KJ84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 123GOLDPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 218Mediates export from ERSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ2KJ84
KOiK14825
OMAiYDMKVQD
OrthoDBiEOG091G0RNG
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015717 TMED5
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PTHR22811:SF41 PTHR22811:SF41, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKTWLPFP VVLLAALLLP RAAGFTPSLD SDFTFTLPAG QKECFYQPMP
60 70 80 90 100
LKASLEIEYQ VLDGAGLDID FHLASPEGKT LVFEQRKSDG VHTIETEVGD
110 120 130 140 150
YMFCFDNTFS TISEKVIFFE LILDNMGEQE QEQEDWKKYI TGTDMLDMKL
160 170 180 190 200
EDILESINSI KSRLSKSGHI QTLLRAFEAR DRNIQESNFD RVNFWSMVNL
210 220
VVMVVVSAIQ VYMLKSLFED KRKSRT
Length:226
Mass (Da):25,875
Last modified:March 7, 2006 - v1
Checksum:i36E306A97489647E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030528 mRNA Translation: ABQ12968.1
BC105474 mRNA Translation: AAI05475.1
RefSeqiNP_001039842.1, NM_001046377.1
UniGeneiBt.27858

Genome annotation databases

EnsembliENSBTAT00000032159; ENSBTAP00000032097; ENSBTAG00000020180
GeneIDi534351
KEGGibta:534351

Similar proteinsi

Entry informationi

Entry nameiTMED5_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ84
Secondary accession number(s): A5D9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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