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Protein

Arginase-1

Gene

ARG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (ARG2), Arginase-1 (ARG1), Arginase-2, mitochondrial (ARG2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 2PROSITE-ProRule annotation1
Metal bindingi126Manganese 2PROSITE-ProRule annotation1
Metal bindingi128Manganese 1PROSITE-ProRule annotation1
Binding sitei183SubstrateBy similarity1
Metal bindingi232Manganese 1PROSITE-ProRule annotation1
Metal bindingi232Manganese 2PROSITE-ProRule annotation1
Metal bindingi234Manganese 2PROSITE-ProRule annotation1
Binding sitei246SubstrateBy similarity1
Binding sitei277SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism, Urea cycle
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-70635 Urea cycle
SABIO-RKiQ2KJ64
UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1By similarity)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:ARG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:26070 ARG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075060

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002403391 – 322Arginase-1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei75N6-succinyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJ64
PeptideAtlasiQ2KJ64
PRIDEiQ2KJ64

Expressioni

Gene expression databases

BgeeiENSBTAG00000012403

Interactioni

Subunit structurei

Homotrimer (By similarity). Interacts with CMTM6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016461

Chemistry databases

BindingDBiQ2KJ64

Structurei

3D structure databases

ProteinModelPortaliQ2KJ64
SMRiQ2KJ64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 130Substrate bindingBy similarity5
Regioni137 – 139Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA
GeneTreeiENSGT00530000063082
HOGENOMiHOG000204319
HOVERGENiHBG003030
InParanoidiQ2KJ64
KOiK01476
OMAiEQECDVK
OrthoDBiEOG091G0A38
TreeFamiTF300034

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KJ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY
60 70 80 90 100
GDLSFADNLD DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD
110 120 130 140 150
HSLAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK
160 170 180 190 200
ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM
210 220 230 240 250
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVQG
260 270 280 290 300
GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT
310 320
MACFGVAREG NHKPIDYLSP PK
Length:322
Mass (Da):35,009
Last modified:March 7, 2006 - v1
Checksum:iB71BE758F1AB83CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105497 mRNA Translation: AAI05498.1
RefSeqiNP_001039619.1, NM_001046154.1
XP_005210981.1, XM_005210924.3
XP_010806852.1, XM_010808550.2
UniGeneiBt.97117

Genome annotation databases

EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403
GeneIDi513608
KEGGibta:513608

Similar proteinsi

Entry informationi

Entry nameiARGI1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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