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Protein

LIM and senescent cell antigen-like-containing domain protein 2

Gene

LIMS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain protein 2
Alternative name(s):
Particularly interesting new Cys-His protein 2
Short name:
PINCH-2
Gene namesi
Name:LIMS2
Synonyms:PINCH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:30891 LIMS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002660101 – 341LIM and senescent cell antigen-like-containing domain protein 2Add BLAST341

Proteomic databases

PaxDbiQ2KJ33
PRIDEiQ2KJ33

Expressioni

Gene expression databases

BgeeiENSBTAG00000006262 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with TGFB1I1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008216

Structurei

3D structure databases

ProteinModelPortaliQ2KJ33
SMRiQ2KJ33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 74LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini76 – 133LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini138 – 195LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST58
Domaini196 – 255LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST60
Domaini256 – 315LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
InParanoidiQ2KJ33
OMAiDHFSCTH
OrthoDBiEOG091G08K3
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q2KJ33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGSNMSNAL ANAVCQRCQA RFAPAERIVN SNGELYHEHC FVCAQCFRPF
60 70 80 90 100
PEGLFYEFEG RKYCEHDFQM LFAPCCGSCG EFIIGRVIKA MNNNWHPGCF
110 120 130 140 150
RCELCDVELA DLGFVKNAGR HLCRPCHNRE KAKGLGKYIC QRCHLVIDEQ
160 170 180 190 200
PLMFKNDAYH PDHFSCTHCG KELTAEAREL KGELYCLPCH DKMGVPICGA
210 220 230 240 250
CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK GLAYCETHYN
260 270 280 290 300
QLFGDVCYTC SHVIEGDVVS ALNKAWCVHC FSCSTCNSRL TLKNKFVEFD
310 320 330 340
MKPVCKRCYE KFPLELKKRL KKLSELAARR AQPKSSGLHP A
Length:341
Mass (Da):38,895
Last modified:December 12, 2006 - v2
Checksum:iD7B217FCC8D6792B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105544 mRNA Translation: AAI05545.2
RefSeqiNP_001124223.1, NM_001130751.1
UniGeneiBt.32348

Genome annotation databases

EnsembliENSBTAT00000008216; ENSBTAP00000008216; ENSBTAG00000006262
GeneIDi515401
KEGGibta:515401

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105544 mRNA Translation: AAI05545.2
RefSeqiNP_001124223.1, NM_001130751.1
UniGeneiBt.32348

3D structure databases

ProteinModelPortaliQ2KJ33
SMRiQ2KJ33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008216

Proteomic databases

PaxDbiQ2KJ33
PRIDEiQ2KJ33

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008216; ENSBTAP00000008216; ENSBTAG00000006262
GeneIDi515401
KEGGibta:515401

Organism-specific databases

CTDi55679
VGNCiVGNC:30891 LIMS2

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
InParanoidiQ2KJ33
OMAiDHFSCTH
OrthoDBiEOG091G08K3
TreeFamiTF314113

Gene expression databases

BgeeiENSBTAG00000006262 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIMS2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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