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Protein

Hairy/enhancer-of-split related with YRPW motif protein 1

Gene

HEY1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Gene namesi
Name:HEY1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:29828 HEY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691761 – 304Hairy/enhancer-of-split related with YRPW motif protein 1Add BLAST304

Proteomic databases

PaxDbiQ2KIN4
PRIDEiQ2KIN4

Expressioni

Gene expression databases

BgeeiENSBTAG00000015717 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020864

Structurei

3D structure databases

ProteinModelPortaliQ2KIN4
SMRiQ2KIN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 104bHLHPROSITE-ProRule annotationAdd BLAST56
Domaini122 – 158OrangePROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 117Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi294 – 297YRPW motif4

Sequence similaritiesi

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ2KIN4
KOiK09091
OMAiHPHVAHP
OrthoDBiEOG091G0HWC
TreeFamiTF323617

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KIN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRAHPEYSS SESELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR
60 70 80 90 100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH
110 120 130 140 150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL
160 170 180 190 200
RVRLVSHLNN YASQREAASG AHAGLGHIPW GSAFGHHPHV AHPLLLSQST
210 220 230 240 250
HGNTGTSASP TESHHQGRLA TAHPEASALR APPSGGLGPV LPVVTSASKL
260 270 280 290 300
SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE

IGAF
Length:304
Mass (Da):32,572
Last modified:March 7, 2006 - v1
Checksum:i0D1DDF3D0F8E2D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112574 mRNA Translation: AAI12575.1
RefSeqiNP_001001172.2, NM_001001172.3
UniGeneiBt.59697

Genome annotation databases

EnsembliENSBTAT00000020864; ENSBTAP00000020864; ENSBTAG00000015717
GeneIDi408005
KEGGibta:408005

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112574 mRNA Translation: AAI12575.1
RefSeqiNP_001001172.2, NM_001001172.3
UniGeneiBt.59697

3D structure databases

ProteinModelPortaliQ2KIN4
SMRiQ2KIN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020864

Proteomic databases

PaxDbiQ2KIN4
PRIDEiQ2KIN4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020864; ENSBTAP00000020864; ENSBTAG00000015717
GeneIDi408005
KEGGibta:408005

Organism-specific databases

CTDi23462
VGNCiVGNC:29828 HEY1

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ2KIN4
KOiK09091
OMAiHPHVAHP
OrthoDBiEOG091G0HWC
TreeFamiTF323617

Gene expression databases

BgeeiENSBTAG00000015717 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEY1_BOVIN
AccessioniPrimary (citable) accession number: Q2KIN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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