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UniProtKB - Q2KIJ2 (MET18_BOVIN)
Protein
Histidine protein methyltransferase 1 homolog
Gene
METTL18
Organism
Bos taurus (Bovine)
Status
Functioni
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3. Through the methylation of RPL3 regulates the dynamics of pre-rRNA processing, ribosome biogenesis, and translation.
By similarityCatalytic activityi
- L-histidyl-[protein] + S-adenosyl-L-methionine = H+ + Nτ-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteineBy similarityEC:2.1.1.85By similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 195 | S-adenosyl-L-methionine; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 294 | S-adenosyl-L-methionineBy similarity | 1 |
GO - Molecular functioni
- protein-L-histidine N-tele-methyltransferase activity Source: UniProtKB
GO - Biological processi
- peptidyl-histidine methylation, to form tele-methylhistidine Source: GO_Central
- peptidyl-lysine monomethylation Source: UniProtKB
- regulation of ribosome biogenesis Source: UniProtKB
- regulation of rRNA processing Source: UniProtKB
- regulation of translation Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Histidine protein methyltransferase 1 homologCurated (EC:2.1.1.85By similarity)Alternative name(s): Methyltransferase-like protein 18 |
Gene namesi | Name:METTL18 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247198 | 1 – 373 | Histidine protein methyltransferase 1 homologAdd BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Modified residuei | 154 | Tele-methylhistidineBy similarity | 1 |
Post-translational modificationi
Monomethylated at His-154 through automethylation. Automethylation at His-154 positively regulates the methyltransferase activity toward RPL3. Probably methylated on other residues.By similarity
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | Q2KIJ2 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000021671, Expressed in spleen and 98 other tissues |
Interactioni
Subunit structurei
Interacts with GRWD1 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000028878 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 52 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 64 – 94 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 168 – 172 | S-adenosyl-L-methionine bindingBy similarity | 5 | |
Regioni | 216 – 218 | S-adenosyl-L-methionine bindingBy similarity | 3 | |
Regioni | 269 – 271 | S-adenosyl-L-methionine bindingBy similarity | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 247 – 253 | Nuclear localization signalBy similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 52 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 72 – 90 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2920, Eukaryota |
HOGENOMi | CLU_038704_0_1_1 |
InParanoidi | Q2KIJ2 |
OrthoDBi | 803097at2759 |
TreeFami | TF320884 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR019410, Methyltransf_16 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR14614, PTHR14614, 1 hit |
Pfami | View protein in Pfam PF10294, Methyltransf_16, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2KIJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFQFNFTIE DHLEDELTSL GDGALALHSS KESLVSERQK GTHRDKKCST
60 70 80 90 100
EQSDLLQDHL WEHKSERNEA PSQDPDSSFG AANSSSNLEP HEEKPCLKVA
110 120 130 140 150
KEHAVPKDLK KVLENKVTET LPGLQHVNIS IMKTTLLKEN FPGENIISKS
160 170 180 190 200
FSSHSDLISG VYEGGLKIWE CTFDLLAYLT KAKVKFAGKK VLDLGCGSGL
210 220 230 240 250
LGIMALKGGA KEIHFQDYNS VVIDEVTLPN VVANSTLEDE ENDVNEPDVK
260 270 280 290 300
RLRRSTVAQE LCKCRFFSGE WSEFCKLVLS SEKLFEKYDL ILTSETIYNP
310 320 330 340 350
DYYVPLHQTF LRLLDKNGQV LLASKVHYFG VGGGTHLFQK FVEERNVFET
360 370
RTLEIIDEGL KRCLIEMTFK YPT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112618 mRNA Translation: AAI12619.1 |
RefSeqi | NP_001073825.1, NM_001080356.2 XP_005216978.1, XM_005216921.1 XP_005216979.1, XM_005216922.3 |
Genome annotation databases
GeneIDi | 783955 |
KEGGi | bta:783955 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112618 mRNA Translation: AAI12619.1 |
RefSeqi | NP_001073825.1, NM_001080356.2 XP_005216978.1, XM_005216921.1 XP_005216979.1, XM_005216922.3 |
3D structure databases
AlphaFoldDBi | Q2KIJ2 |
SMRi | Q2KIJ2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000028878 |
Proteomic databases
PaxDbi | Q2KIJ2 |
Genome annotation databases
GeneIDi | 783955 |
KEGGi | bta:783955 |
Organism-specific databases
CTDi | 92342 |
Phylogenomic databases
eggNOGi | KOG2920, Eukaryota |
HOGENOMi | CLU_038704_0_1_1 |
InParanoidi | Q2KIJ2 |
OrthoDBi | 803097at2759 |
TreeFami | TF320884 |
Gene expression databases
Bgeei | ENSBTAG00000021671, Expressed in spleen and 98 other tissues |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR019410, Methyltransf_16 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR14614, PTHR14614, 1 hit |
Pfami | View protein in Pfam PF10294, Methyltransf_16, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MET18_BOVIN | |
Accessioni | Q2KIJ2Primary (citable) accession number: Q2KIJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families