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Protein

Histone H2B

Gene

HIST1H2BI

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-201722 Formation of the beta-catenin:TCF transactivating complex
R-BTA-212300 PRC2 methylates histones and DNA
R-BTA-2299718 Condensation of Prophase Chromosomes
R-BTA-2559580 Oxidative Stress Induced Senescence
R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-BTA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-BTA-3214847 HATs acetylate histones
R-BTA-427359 SIRT1 negatively regulates rRNA expression
R-BTA-427413 NoRC negatively regulates rRNA expression
R-BTA-5250924 B-WICH complex positively regulates rRNA expression
R-BTA-5578749 Transcriptional regulation by small RNAs
R-BTA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-BTA-5689880 Ub-specific processing proteases
R-BTA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-BTA-5693571 Nonhomologous End-Joining (NHEJ)
R-BTA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-BTA-69473 G2/M DNA damage checkpoint
R-BTA-73728 RNA Polymerase I Promoter Opening
R-BTA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-BTA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-BTA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BIImported
Synonyms:HIST1H2BDImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ2KII5

Expressioni

Gene expression databases

BgeeiENSBTAG00000031778 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027308

Structurei

3D structure databases

SMRiQ2KII5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 101HistoneInterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOGENOMiHOG000231213
HOVERGENiHBG007774
KOiK11252
OMAiTMAANDI
OrthoDBiEOG091G0XGD
TreeFamiTF300212

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KII5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEPTKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,936
Last modified:March 7, 2006 - v1
Checksum:iFAE8378A44BE7028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055497 Genomic DNA No translation available.
BC112625 mRNA Translation: AAI12626.1
RefSeqiNP_001039711.1, NM_001046246.2
XP_005223819.1, XM_005223762.2
UniGeneiBt.92794

Genome annotation databases

EnsembliENSBTAT00000027308; ENSBTAP00000027308; ENSBTAG00000031778
GeneIDi519935
KEGGibta:519935

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055497 Genomic DNA No translation available.
BC112625 mRNA Translation: AAI12626.1
RefSeqiNP_001039711.1, NM_001046246.2
XP_005223819.1, XM_005223762.2
UniGeneiBt.92794

3D structure databases

SMRiQ2KII5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027308

Proteomic databases

PRIDEiQ2KII5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027308; ENSBTAP00000027308; ENSBTAG00000031778
GeneIDi519935
KEGGibta:519935

Organism-specific databases

CTDi3017

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOGENOMiHOG000231213
HOVERGENiHBG007774
KOiK11252
OMAiTMAANDI
OrthoDBiEOG091G0XGD
TreeFamiTF300212

Enzyme and pathway databases

ReactomeiR-BTA-201722 Formation of the beta-catenin:TCF transactivating complex
R-BTA-212300 PRC2 methylates histones and DNA
R-BTA-2299718 Condensation of Prophase Chromosomes
R-BTA-2559580 Oxidative Stress Induced Senescence
R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-BTA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-BTA-3214847 HATs acetylate histones
R-BTA-427359 SIRT1 negatively regulates rRNA expression
R-BTA-427413 NoRC negatively regulates rRNA expression
R-BTA-5250924 B-WICH complex positively regulates rRNA expression
R-BTA-5578749 Transcriptional regulation by small RNAs
R-BTA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-BTA-5689880 Ub-specific processing proteases
R-BTA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-BTA-5693571 Nonhomologous End-Joining (NHEJ)
R-BTA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-BTA-69473 G2/M DNA damage checkpoint
R-BTA-73728 RNA Polymerase I Promoter Opening
R-BTA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-BTA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-BTA-9018519 Estrogen-dependent gene expression

Gene expression databases

BgeeiENSBTAG00000031778 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ2KII5_BOVIN
AccessioniPrimary (citable) accession number: Q2KII5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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