UniProtKB - Q2KIC5 (ITPA_BOVIN)
Inosine triphosphate pyrophosphatase
ITPA
Functioni
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
UniRule annotationCatalytic activityi
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H+UniRule annotationEC:3.6.1.9UniRule annotationThis reaction proceeds in the forwardUniRule annotation direction.
- a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H+UniRule annotationEC:3.6.1.9UniRule annotationThis reaction proceeds in the forwardUniRule annotation direction.
- EC:3.6.1.9UniRule annotationThis reaction proceeds in the forwardUniRule annotation direction.
- EC:3.6.1.9UniRule annotationThis reaction proceeds in the forwardUniRule annotation direction.
- EC:3.6.1.9UniRule annotationThis reaction proceeds in the forwardUniRule annotation direction.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 44 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 56 | ITPUniRule annotation | 1 | |
Binding sitei | 89 | ITPUniRule annotation | 1 | |
Binding sitei | 172 | ITPUniRule annotation | 1 |
GO - Molecular functioni
- dTTP diphosphatase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- NADH pyrophosphatase activity Source: UniProtKB-EC
- nucleotide binding Source: UniProtKB-KW
GO - Biological processi
- deoxyribonucleoside triphosphate catabolic process Source: UniProtKB-UniRule
- nucleotide metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Nucleotide metabolism |
Ligand | Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Inosine triphosphate pyrophosphataseUniRule annotation (EC:3.6.1.9UniRule annotation)Short name: ITPaseUniRule annotation Short name: Inosine triphosphataseUniRule annotation Alternative name(s): Non-canonical purine NTP pyrophosphataseUniRule annotation Non-standard purine NTP pyrophosphataseUniRule annotation Nucleoside-triphosphate diphosphataseUniRule annotation Nucleoside-triphosphate pyrophosphataseUniRule annotation Short name: NTPaseUniRule annotation |
Gene namesi | Name:ITPAUniRule annotation |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000013776 |
VGNCi | VGNC:30342, ITPA |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotation | |||
ChainiPRO_0000306869 | 2 – 208 | Inosine triphosphate pyrophosphataseAdd BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineUniRule annotationBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q2KIC5 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000013776, Expressed in testis and 97 other tissues |
ExpressionAtlasi | Q2KIC5, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000018301 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 19 | ITP bindingUniRule annotation | 6 | |
Regioni | 72 – 73 | ITP bindingUniRule annotation | 2 | |
Regioni | 149 – 152 | ITP bindingUniRule annotation | 4 | |
Regioni | 177 – 178 | ITP bindingUniRule annotation | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3222, Eukaryota |
GeneTreei | ENSGT00390000015399 |
HOGENOMi | CLU_082080_1_1_1 |
InParanoidi | Q2KIC5 |
OrthoDBi | 1298391at2759 |
TreeFami | TF105614 |
Family and domain databases
CDDi | cd00515, HAM1, 1 hit |
Gene3Di | 3.90.950.10, 1 hit |
HAMAPi | MF_03148, HAM1_NTPase, 1 hit |
InterProi | View protein in InterPro IPR002637, Ham1p-like IPR027502, ITPase IPR029001, ITPase-like_fam |
PANTHERi | PTHR11067, PTHR11067, 1 hit |
Pfami | View protein in Pfam PF01725, Ham1p_like, 1 hit |
SUPFAMi | SSF52972, SSF52972, 1 hit |
TIGRFAMsi | TIGR00042, TIGR00042, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAASLAGKKI VFVTGNAKKL EEVIQILGDK FPCTLVAQKI DLPEYQGEPD
60 70 80 90 100
EISIRKCQEA ARQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL
110 120 130 140 150
HQLLEGFQDK SAYALCTFAF STGDPNEPVR LFRGRTMGRI VVPRGCRDFG
160 170 180 190 200
WDPCFQPDGY EQTYAEMPKA EKNTISHRFR ALLALQEYFS SLTPGVGDDH
PSWGSGEG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MQA8 | A0A3Q1MQA8_BOVIN | Inosine triphosphate pyrophosphatas... | ITPA | 216 | Annotation score: | ||
A0A3Q1MNG0 | A0A3Q1MNG0_BOVIN | Inosine triphosphate pyrophosphatas... | ITPA | 304 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112688 mRNA Translation: AAI12689.1 |
RefSeqi | NP_001069750.1, NM_001076282.2 |
Genome annotation databases
Ensembli | ENSBTAT00000018301; ENSBTAP00000018301; ENSBTAG00000013776 |
GeneIDi | 613653 |
KEGGi | bta:613653 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112688 mRNA Translation: AAI12689.1 |
RefSeqi | NP_001069750.1, NM_001076282.2 |
3D structure databases
AlphaFoldDBi | Q2KIC5 |
SMRi | Q2KIC5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000018301 |
Proteomic databases
PaxDbi | Q2KIC5 |
Genome annotation databases
Ensembli | ENSBTAT00000018301; ENSBTAP00000018301; ENSBTAG00000013776 |
GeneIDi | 613653 |
KEGGi | bta:613653 |
Organism-specific databases
CTDi | 3704 |
VEuPathDBi | HostDB:ENSBTAG00000013776 |
VGNCi | VGNC:30342, ITPA |
Phylogenomic databases
eggNOGi | KOG3222, Eukaryota |
GeneTreei | ENSGT00390000015399 |
HOGENOMi | CLU_082080_1_1_1 |
InParanoidi | Q2KIC5 |
OrthoDBi | 1298391at2759 |
TreeFami | TF105614 |
Gene expression databases
Bgeei | ENSBTAG00000013776, Expressed in testis and 97 other tissues |
ExpressionAtlasi | Q2KIC5, baseline and differential |
Family and domain databases
CDDi | cd00515, HAM1, 1 hit |
Gene3Di | 3.90.950.10, 1 hit |
HAMAPi | MF_03148, HAM1_NTPase, 1 hit |
InterProi | View protein in InterPro IPR002637, Ham1p-like IPR027502, ITPase IPR029001, ITPase-like_fam |
PANTHERi | PTHR11067, PTHR11067, 1 hit |
Pfami | View protein in Pfam PF01725, Ham1p_like, 1 hit |
SUPFAMi | SSF52972, SSF52972, 1 hit |
TIGRFAMsi | TIGR00042, TIGR00042, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ITPA_BOVIN | |
Accessioni | Q2KIC5Primary (citable) accession number: Q2KIC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | March 7, 2006 | |
Last modified: | May 25, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families