We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q2KIA4 (SCD5_BOVIN)
Protein
Stearoyl-CoA desaturase 5
Gene
SCD5
Organism
Bos taurus (Bovine)
Status
Functioni
Stearoyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways.
By similarityMiscellaneous
This protein has no ortholog in rodents.Curated
Catalytic activityi
- 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OBy similarityEC:1.14.19.1By similarity
- 2 Fe(II)-[cytochrome b5] + 2 H+ + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OBy similarity
Cofactori
Fe2+By similarityNote: Expected to bind 2 Fe2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | SubstrateBy similarity | 1 | |
Metal bindingi | 99 | Iron 1By similarity | 1 | |
Metal bindingi | 104 | Iron 1By similarity | 1 | |
Binding sitei | 127 | SubstrateBy similarity | 1 | |
Binding sitei | 134 | SubstrateBy similarity | 1 | |
Binding sitei | 135 | SubstrateBy similarity | 1 | |
Metal bindingi | 136 | Iron 1By similarity | 1 | |
Metal bindingi | 139 | Iron 2By similarity | 1 | |
Metal bindingi | 140 | Iron 1By similarity | 1 | |
Binding sitei | 167 | SubstrateBy similarity | 1 | |
Binding sitei | 168 | SubstrateBy similarity | 1 | |
Binding sitei | 241 | SubstrateBy similarity | 1 | |
Metal bindingi | 248 | Iron 2By similarity | 1 | |
Metal bindingi | 277 | Iron 2By similarity | 1 | |
Metal bindingi | 280 | Iron 1By similarity | 1 | |
Metal bindingi | 281 | Iron 2By similarity | 1 |
GO - Molecular functioni
- iron ion binding Source: GO_Central
- oxidoreductase activity Source: UniProtKB
- stearoyl-CoA 9-desaturase activity Source: UniProtKB
GO - Biological processi
- monounsaturated fatty acid biosynthetic process Source: GO_Central
- unsaturated fatty acid biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.19.1, 908 |
Reactomei | R-BTA-75105, Fatty acyl-CoA biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Stearoyl-CoA desaturase 5 (EC:1.14.19.1By similarity)Alternative name(s): Acyl-CoA-desaturase 4 Stearoyl-CoA 9-desaturase |
Gene namesi | Name:SCD5 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000022449 |
VGNCi | VGNC:34328, SCD5 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 54 | CytoplasmicCuratedAdd BLAST | 54 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 77 | LumenalCurated | 2 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 198 | CytoplasmicCuratedAdd BLAST | 100 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 227 | LumenalCurated | 8 | |
Transmembranei | 228 – 247 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 248 – 335 | CytoplasmicCuratedAdd BLAST | 88 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312652 | 1 – 335 | Stearoyl-CoA desaturase 5Add BLAST | 335 |
Proteomic databases
PaxDbi | Q2KIA4 |
Expressioni
Tissue specificityi
Detected in brain.1 Publication
Gene expression databases
Bgeei | ENSBTAG00000022449, Expressed in hypothalamus and 90 other tissues |
Interactioni
Subunit structurei
May self-associate and form homodimers.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025820 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 44 | DisorderedSequence analysisAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 99 – 104 | Histidine box-1Curated | 6 | |
Motifi | 136 – 140 | Histidine box-2Curated | 5 | |
Motifi | 277 – 281 | Histidine box-3Curated | 5 |
Domaini
The histidine box domains are involved in binding the catalytic metal ions.By similarity
Sequence similaritiesi
Belongs to the fatty acid desaturase type 1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1600, Eukaryota |
GeneTreei | ENSGT00940000162090 |
HOGENOMi | CLU_027359_0_0_1 |
InParanoidi | Q2KIA4 |
OMAi | CQHGPID |
OrthoDBi | 971318at2759 |
TreeFami | TF313251 |
Family and domain databases
CDDi | cd03505, Delta9-FADS-like, 1 hit |
InterProi | View protein in InterPro IPR015876, Acyl-CoA_DS IPR005804, FA_desaturase_dom IPR001522, FADS-1_CS |
PANTHERi | PTHR11351, PTHR11351, 1 hit |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
PRINTSi | PR00075, FACDDSATRASE |
PROSITEi | View protein in PROSITE PS00476, FATTY_ACID_DESATUR_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2KIA4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPAVDAEK VPFRSAKEEI RAGVGVEGSE GGGGGGGRER PGARGHRQDI
60 70 80 90 100
VWRNVFLMSL LHLAAVYSLV LIPKAQPLTL LWAYFCFLLT ALGVTAGAHR
110 120 130 140 150
LWSHRSYKAK LPLRIFLAAA NSMAFQNDIF EWSRDHRVHH KYSETDADPH
160 170 180 190 200
NARRGFFFSH IGWLFVRKHR DVIEKGRKLD VTDLLADPVV RFQRKYYKIT
210 220 230 240 250
VVLMCFVVPT LVPWYIWGES LWNSYFLASI LRYTISLNVT WLVNSVAHMY
260 270 280 290 300
GNRPYDKHIS PRQNPLVTLG AIGEGFHNYH HTFPFDYSAS EFGLNFNPTT
310 320 330
WFIDFMCWLG LATDRKRATK QMIEARKART GDGSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF014951 mRNA Translation: ABJ99757.1 BC112711 mRNA Translation: AAI12712.1 |
RefSeqi | NP_001070413.1, NM_001076945.1 |
Genome annotation databases
Ensembli | ENSBTAT00000025820; ENSBTAP00000025820; ENSBTAG00000022449 |
GeneIDi | 617419 |
KEGGi | bta:617419 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF014951 mRNA Translation: ABJ99757.1 BC112711 mRNA Translation: AAI12712.1 |
RefSeqi | NP_001070413.1, NM_001076945.1 |
3D structure databases
SMRi | Q2KIA4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025820 |
Proteomic databases
PaxDbi | Q2KIA4 |
Genome annotation databases
Ensembli | ENSBTAT00000025820; ENSBTAP00000025820; ENSBTAG00000022449 |
GeneIDi | 617419 |
KEGGi | bta:617419 |
Organism-specific databases
CTDi | 79966 |
VEuPathDBi | HostDB:ENSBTAG00000022449 |
VGNCi | VGNC:34328, SCD5 |
Phylogenomic databases
eggNOGi | KOG1600, Eukaryota |
GeneTreei | ENSGT00940000162090 |
HOGENOMi | CLU_027359_0_0_1 |
InParanoidi | Q2KIA4 |
OMAi | CQHGPID |
OrthoDBi | 971318at2759 |
TreeFami | TF313251 |
Enzyme and pathway databases
BRENDAi | 1.14.19.1, 908 |
Reactomei | R-BTA-75105, Fatty acyl-CoA biosynthesis |
Gene expression databases
Bgeei | ENSBTAG00000022449, Expressed in hypothalamus and 90 other tissues |
Family and domain databases
CDDi | cd03505, Delta9-FADS-like, 1 hit |
InterProi | View protein in InterPro IPR015876, Acyl-CoA_DS IPR005804, FA_desaturase_dom IPR001522, FADS-1_CS |
PANTHERi | PTHR11351, PTHR11351, 1 hit |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
PRINTSi | PR00075, FACDDSATRASE |
PROSITEi | View protein in PROSITE PS00476, FATTY_ACID_DESATUR_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCD5_BOVIN | |
Accessioni | Q2KIA4Primary (citable) accession number: Q2KIA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families