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Protein

Mitochondrial inner membrane protease subunit 2

Gene

IMMP2L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43By similarity1
Active sitei91By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 2 (EC:3.4.21.-)
Alternative name(s):
IMP2-like protein
Gene namesi
Name:IMMP2L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 37HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595761 – 177Mitochondrial inner membrane protease subunit 2Add BLAST177

Proteomic databases

PaxDbiQ2KI92
PRIDEiQ2KI92

Expressioni

Gene expression databases

BgeeiENSBTAG00000004398 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005770

Structurei

3D structure databases

ProteinModelPortaliQ2KI92
SMRiQ2KI92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1568 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00550000075044
HOGENOMiHOG000168496
HOVERGENiHBG081792
InParanoidiQ2KI92
OMAiYVFLSRW
OrthoDBiEOG091G0XJX
TreeFamiTF315065

Family and domain databases

InterProiView protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF3 PTHR12383:SF3, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KI92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQSQGWVRR YFKAFCKGFF VAVPVAVTFL DRVACVARVE GASMQPSLNP
60 70 80 90 100
GGSQSSDVVL LNHWKVRNFE VQRGDIVSLV SPKNPEQKII KRVIALEGDI
110 120 130 140 150
VKTMGHKNRY VKVPRGHIWV EGDHHGHSFD SNSFGPVSLG LLHAHATHIL
160 170
WPPKRWQKLE SVLPPERLLV QSEEDCL
Length:177
Mass (Da):19,937
Last modified:March 7, 2006 - v1
Checksum:i501C3D77692D3C5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112723 mRNA Translation: AAI12724.1
UniGeneiBt.5921

Genome annotation databases

EnsembliENSBTAT00000005770; ENSBTAP00000005770; ENSBTAG00000004398

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112723 mRNA Translation: AAI12724.1
UniGeneiBt.5921

3D structure databases

ProteinModelPortaliQ2KI92
SMRiQ2KI92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005770

Proteomic databases

PaxDbiQ2KI92
PRIDEiQ2KI92

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005770; ENSBTAP00000005770; ENSBTAG00000004398

Phylogenomic databases

eggNOGiKOG1568 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00550000075044
HOGENOMiHOG000168496
HOVERGENiHBG081792
InParanoidiQ2KI92
OMAiYVFLSRW
OrthoDBiEOG091G0XJX
TreeFamiTF315065

Gene expression databases

BgeeiENSBTAG00000004398 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF3 PTHR12383:SF3, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00761 SPASE_I_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP2L_BOVIN
AccessioniPrimary (citable) accession number: Q2KI92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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