UniProtKB - Q2KI78 (NDP_BOVIN)
Norrin
NDP
Functioni
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- extracellular matrix-cell signaling Source: Ensembl
- Norrin signaling pathway Source: Ensembl
- placenta development Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- retina vasculature morphogenesis in camera-type eye Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: NorrinAlternative name(s): Norrie disease protein homolog |
Gene namesi | Name:NDP |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000012623 |
VGNCi | VGNC:31939, NDP |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cell surface Source: Ensembl
- collagen-containing extracellular matrix Source: Ensembl
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000247542 | 25 – 133 | NorrinAdd BLAST | 109 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 39 ↔ 96 | By similarity | ||
Disulfide bondi | 55 ↔ 110 | By similarity | ||
Disulfide bondi | 65 ↔ 126 | By similarity | ||
Disulfide bondi | 69 ↔ 128 | By similarity | ||
Disulfide bondi | 93 | Interchain (with C-95)By similarity | ||
Disulfide bondi | 95 | Interchain (with C-93)By similarity | ||
Disulfide bondi | 131 | InterchainBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q2KI78 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012623, Expressed in uterine cervix and 62 other tissues |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity.
Interacts with LRP6 (via Beta-propellers 1 and 2).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016757 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 132 | CTCKPROSITE-ProRule annotationAdd BLAST | 94 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT00390000004304 |
HOGENOMi | CLU_153977_0_0_1 |
InParanoidi | Q2KI78 |
OMAi | DPGRCMR |
OrthoDBi | 1589857at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR003064, Norrie_dis |
PANTHERi | PTHR28611, PTHR28611, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
PRINTSi | PR01304, NORRIEDSEASE |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRNHVLAASF SMLSLLALMG DTDSKTESSF MMDSDPQRCM RHHYVDSISH
60 70 80 90 100
PLYKCSSKMV LLARCEGHCS QASRSEPLVS FSTVLKQPFR SSCHCCRPQT
110 120 130
SKLKALRLRC SGGMRLTATY RYILSCHCEE CSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112738 mRNA Translation: AAI12739.1 |
RefSeqi | NP_001039555.1, NM_001046090.2 XP_005228345.1, XM_005228288.3 XP_005228346.1, XM_005228289.3 XP_005228347.1, XM_005228290.3 XP_010820371.1, XM_010822069.2 |
Genome annotation databases
Ensembli | ENSBTAT00000016757; ENSBTAP00000016757; ENSBTAG00000012623 ENSBTAT00000072339; ENSBTAP00000066041; ENSBTAG00000012623 |
GeneIDi | 511596 |
KEGGi | bta:511596 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC112738 mRNA Translation: AAI12739.1 |
RefSeqi | NP_001039555.1, NM_001046090.2 XP_005228345.1, XM_005228288.3 XP_005228346.1, XM_005228289.3 XP_005228347.1, XM_005228290.3 XP_010820371.1, XM_010822069.2 |
3D structure databases
SMRi | Q2KI78 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016757 |
Proteomic databases
PaxDbi | Q2KI78 |
Genome annotation databases
Ensembli | ENSBTAT00000016757; ENSBTAP00000016757; ENSBTAG00000012623 ENSBTAT00000072339; ENSBTAP00000066041; ENSBTAG00000012623 |
GeneIDi | 511596 |
KEGGi | bta:511596 |
Organism-specific databases
CTDi | 4693 |
VEuPathDBi | HostDB:ENSBTAG00000012623 |
VGNCi | VGNC:31939, NDP |
Phylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT00390000004304 |
HOGENOMi | CLU_153977_0_0_1 |
InParanoidi | Q2KI78 |
OMAi | DPGRCMR |
OrthoDBi | 1589857at2759 |
Gene expression databases
Bgeei | ENSBTAG00000012623, Expressed in uterine cervix and 62 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR003064, Norrie_dis |
PANTHERi | PTHR28611, PTHR28611, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
PRINTSi | PR01304, NORRIEDSEASE |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDP_BOVIN | |
Accessioni | Q2KI78Primary (citable) accession number: Q2KI78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |