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Protein

Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Gene

PTCD3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial RNA-binding protein that has a role in mitochondrial translation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-BTA-5389840 Mitochondrial translation elongation
R-BTA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Alternative name(s):
28S ribosomal protein S39, mitochondrial
Short name:
MRP-S39
Gene namesi
Name:PTCD3
Synonyms:MRPS39
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:33491 PTCD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionSequence analysisAdd BLAST37
ChainiPRO_000030502738 – 688Pentatricopeptide repeat domain-containing protein 3, mitochondrialAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KI62
PRIDEiQ2KI62

Expressioni

Gene expression databases

BgeeiENSBTAG00000006482 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008498

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 183PPR 1Add BLAST35
Repeati184 – 219PPR 2Add BLAST36
Repeati258 – 292PPR 3Add BLAST35
Repeati293 – 333PPR 4Add BLAST41
Repeati334 – 370PPR 5Add BLAST37
Repeati371 – 412PPR 6Add BLAST42
Repeati415 – 449PPR 7Add BLAST35
Repeati457 – 491PPR 8Add BLAST35
Repeati492 – 526PPR 9Add BLAST35
Repeati575 – 609PPR 10Add BLAST35

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4422 Eukaryota
ENOG410XNQS LUCA
GeneTreeiENSGT00390000016876
HOGENOMiHOG000115760
HOVERGENiHBG068809
InParanoidiQ2KI62
KOiK17659
OMAiAPHYKYH
OrthoDBiEOG091G03F0
TreeFamiTF320158

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR037387 PTCD3
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR16276 PTHR16276, 1 hit
PfamiView protein in Pfam
PF13041 PPR_2, 1 hit
PF13812 PPR_3, 1 hit
PROSITEiView protein in PROSITE
PS51375 PPR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KI62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVASARWL RVSCGLCVPL TARRAGPCGR TPSSRFYSGS AAVPKDEGAD
60 70 80 90 100
IAGTEEVVIP KKKTWDKVAV LQALASTVHR DTTAAPYAFQ DDPYLIPTSS
110 120 130 140 150
VESHSFLLAK KSGENAAKFI INSYPKYFQK DIAEPHIPCL MPEYFEPQIE
160 170 180 190 200
EISEAALQER IKLKKVKASV DIFDQLLQAG TTVSLETTNS LLDLLCYYGN
210 220 230 240 250
QEPSTNYNFQ QHEQTEELEE AEEGDNMKSK KKAGHQLGVT WRARNHAERI
260 270 280 290 300
FALMPEKNAH SYCTMIRGMV KHRAHTQALS MYTELLNNRL RADVHTFNSL
310 320 330 340 350
IEATALVVNA KFEEKWNNIL DLLKQMVAQN VKPNLQTFNT ILKCLRRFYA
360 370 380 390 400
FGKLPALQTF REMKAIGIEP SLATYHHIIQ LFYQHESPSK GSSLIIYDIM
410 420 430 440 450
DEITGKTFSP KDPDDDMFFQ SAMRVCSSLR DLELAYQVHG LLNTGDNRKF
460 470 480 490 500
IGPDPRRNFY YSKFFSLLCL MEQIDVTLKW YKDLIPSVFF PHSQTLIDLL
510 520 530 540 550
QALDVANRLE MIPQIWKDSK EYGHTFRSDL KEEILMLMAR DQHPPELQAA
560 570 580 590 600
FADCAADIKS TYESQDARQT ASEWPANSLN YIAILFLRAG RTQEAWKMLG
610 620 630 640 650
LFRKHNKIPR NELLNEFMDS AKASSSPAQA VEVVKLANSF SLPICEGLTQ
660 670 680
RLTADFTLSQ EQKEALGDLT ALTSDSESDS DSDTSKDK
Length:688
Mass (Da):77,831
Last modified:March 7, 2006 - v1
Checksum:i7A95BAA060753958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112757 mRNA Translation: AAI12758.1
RefSeqiNP_001039499.1, NM_001046034.1
UniGeneiBt.59426

Genome annotation databases

EnsembliENSBTAT00000008498; ENSBTAP00000008498; ENSBTAG00000006482
GeneIDi509502
KEGGibta:509502

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112757 mRNA Translation: AAI12758.1
RefSeqiNP_001039499.1, NM_001046034.1
UniGeneiBt.59426

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JD5electron microscopy7.00o1-688[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008498

Proteomic databases

PaxDbiQ2KI62
PRIDEiQ2KI62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008498; ENSBTAP00000008498; ENSBTAG00000006482
GeneIDi509502
KEGGibta:509502

Organism-specific databases

CTDi55037
VGNCiVGNC:33491 PTCD3

Phylogenomic databases

eggNOGiKOG4422 Eukaryota
ENOG410XNQS LUCA
GeneTreeiENSGT00390000016876
HOGENOMiHOG000115760
HOVERGENiHBG068809
InParanoidiQ2KI62
KOiK17659
OMAiAPHYKYH
OrthoDBiEOG091G03F0
TreeFamiTF320158

Enzyme and pathway databases

ReactomeiR-BTA-5389840 Mitochondrial translation elongation
R-BTA-5419276 Mitochondrial translation termination

Gene expression databases

BgeeiENSBTAG00000006482 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR037387 PTCD3
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR16276 PTHR16276, 1 hit
PfamiView protein in Pfam
PF13041 PPR_2, 1 hit
PF13812 PPR_3, 1 hit
PROSITEiView protein in PROSITE
PS51375 PPR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTCD3_BOVIN
AccessioniPrimary (citable) accession number: Q2KI62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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