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Protein

Glutaryl-CoA dehydrogenase, mitochondrial

Gene

GCDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).By similarity

Catalytic activityi

Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi: lysine degradation

This protein is involved in the pathway lysine degradation, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway lysine degradation and in Amino-acid metabolism.

Pathwayi: tryptophan metabolism

This protein is involved in the pathway tryptophan metabolism, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway tryptophan metabolism and in Amino-acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186FADBy similarity1
Binding sitei186Substrate; via carbonyl oxygenBy similarity1
Binding sitei294SubstrateBy similarity1
Binding sitei319FADBy similarity1
Binding sitei330FADBy similarity1
Active sitei414Proton acceptorBy similarity1
Binding sitei415Substrate; via amide nitrogenBy similarity1
Binding sitei416FADBy similarity1
Binding sitei434FAD; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 186FADBy similarity10
Nucleotide bindingi177 – 180FADBy similarity4
Nucleotide bindingi212 – 214FADBy similarity3
Nucleotide bindingi387 – 391FADBy similarity5
Nucleotide bindingi416 – 418FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-71064 Lysine catabolism
UniPathwayiUPA00224
UPA00225

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaryl-CoA dehydrogenase, mitochondrial (EC:1.3.8.6)
Short name:
GCD
Gene namesi
Name:GCDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:29282 GCDH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_000028199245 – 438Glutaryl-CoA dehydrogenase, mitochondrialAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KHZ9
PeptideAtlasiQ2KHZ9
PRIDEiQ2KHZ9

Expressioni

Gene expression databases

BgeeiENSBTAG00000016211

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043333

Structurei

3D structure databases

ProteinModelPortaliQ2KHZ9
SMRiQ2KHZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 139Substrate bindingBy similarity2
Regioni287 – 294Substrate bindingBy similarity8

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0138 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131662
HOVERGENiHBG001939
InParanoidiQ2KHZ9
KOiK00252
OMAiTQTYEGQ
OrthoDBiEOG091G07GZ
TreeFamiTF105051

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KHZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRGVYAQL LNRGPGLRVF RSWSSATAQT EKGEKTQSRS AKPSRPEFDW
60 70 80 90 100
RDPLLLEEQL TADEILIRDT FRTYCQERLM PRILLANRNE VFHREIISEM
110 120 130 140 150
GELGMLGPTI QGYSCAGVSS VAYGLLAREL ERVDSGYRSA MSVQSSLVMY
160 170 180 190 200
PIYAYGSEEQ KQKYLPRLAK GELLGCFGLT EPNHGSDPSG METRARHNPS
210 220 230 240 250
SRSYILSGSK TWITNSPVAD LLIVWARCED SCIRGFLLEK GMRGLSTPRI
260 270 280 290 300
EGKFSLRASS TGMIIMDDVE VPEENVLPGV SGLAGPFGCL NNARYGITWG
310 320 330 340 350
VLGAAEFCLH TARQYTLDRI QFGVPLAKNQ LIQKKLADML TEITLGLHAC
360 370 380 390 400
LQLGRLKDQD KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV
410 420 430
IRHVMNLESV NTYEGTHDIH ALILGRAITG IQAFVAGK
Length:438
Mass (Da):48,472
Last modified:March 7, 2006 - v1
Checksum:iC420C9901292CDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112822 mRNA Translation: AAI12823.1
RefSeqiNP_001039404.1, NM_001045939.2
UniGeneiBt.43227

Genome annotation databases

EnsembliENSBTAT00000045996; ENSBTAP00000043333; ENSBTAG00000016211
GeneIDi506310
KEGGibta:506310

Similar proteinsi

Entry informationi

Entry nameiGCDH_BOVIN
AccessioniPrimary (citable) accession number: Q2KHZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health