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Protein

Acyl-CoA-binding domain-containing protein 4

Gene

ACBD4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69Acyl-CoABy similarity1
Binding sitei88Acyl-CoABy similarity1

GO - Molecular functioni

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-390918 Peroxisomal lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 4
Gene namesi
Name:ACBD4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:55767 ACBD4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475861 – 303Acyl-CoA-binding domain-containing protein 4Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KHT9
PRIDEiQ2KHT9

Expressioni

Gene expression databases

BgeeiENSBTAG00000006054 Expressed in 10 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007953

Structurei

3D structure databases

ProteinModelPortaliQ2KHT9
SMRiQ2KHT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 101ACBPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 32Acyl-CoA bindingBy similarity10
Regioni43 – 47Acyl-CoA bindingBy similarity5

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000231479
HOVERGENiHBG028530
InParanoidiQ2KHT9
OMAiFFLLWPF
OrthoDBiEOG091G0NXJ
TreeFamiTF319446

Family and domain databases

CDDicd00435 ACBP, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KHT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIENESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT
60 70 80 90 100
MGPCLIPQPG FWDPIGRYKW EAWNSLGQMS REEAMSAYIT EMKLVAQKVI
110 120 130 140 150
DTVPLGEVAE DMFGYFEPLY QVIPDMPRPP ETFLRRVTGW KEQALNGDAE
160 170 180 190 200
AAPEPPCLPK EPAPPSLESQ PPRDQDSEVF CDSVEQLEPE LVGEEQRGAL
210 220 230 240 250
GGENDTRNSP EPPAEKGRLE GPLLGPQELD SWLVGTVRAL QDSMRDVQGR
260 270 280 290 300
LQSLESMPMP PEQMPPPSAR PRPLRLSGPT LIFFLLWPFI VQWLFRQFRT

QKR
Length:303
Mass (Da):34,440
Last modified:March 7, 2006 - v1
Checksum:i78C94A603D8AA9B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112885 mRNA Translation: AAI12886.1
RefSeqiNP_001039679.1, NM_001046214.1
UniGeneiBt.24821

Genome annotation databases

EnsembliENSBTAT00000007953; ENSBTAP00000007953; ENSBTAG00000006054
GeneIDi515848
KEGGibta:515848

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112885 mRNA Translation: AAI12886.1
RefSeqiNP_001039679.1, NM_001046214.1
UniGeneiBt.24821

3D structure databases

ProteinModelPortaliQ2KHT9
SMRiQ2KHT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007953

Proteomic databases

PaxDbiQ2KHT9
PRIDEiQ2KHT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007953; ENSBTAP00000007953; ENSBTAG00000006054
GeneIDi515848
KEGGibta:515848

Organism-specific databases

CTDi79777
VGNCiVGNC:55767 ACBD4

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000231479
HOVERGENiHBG028530
InParanoidiQ2KHT9
OMAiFFLLWPF
OrthoDBiEOG091G0NXJ
TreeFamiTF319446

Enzyme and pathway databases

ReactomeiR-BTA-390918 Peroxisomal lipid metabolism

Gene expression databases

BgeeiENSBTAG00000006054 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

CDDicd00435 ACBP, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACBD4_BOVIN
AccessioniPrimary (citable) accession number: Q2KHT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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