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Entry version 93 (08 May 2019)
Sequence version 2 (29 Apr 2008)
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Protein

Germ cell-specific gene 1 protein

Gene

GSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.16.5.1 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Germ cell-specific gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSG1
ORF Names:UNQ709/PRO1360
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19716 GSG1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2KHT4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000111305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868096

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187471163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003294611 – 349Germ cell-specific gene 1 proteinAdd BLAST349

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2KHT4

PeptideAtlas

More...
PeptideAtlasi
Q2KHT4

PRoteomics IDEntifications database

More...
PRIDEi
Q2KHT4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61312
61313 [Q2KHT4-2]
61314 [Q2KHT4-3]
61315 [Q2KHT4-4]
61316 [Q2KHT4-5]
61317 [Q2KHT4-6]
61318 [Q2KHT4-7]
61319 [Q2KHT4-8]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2KHT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111305 Expressed in 68 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2KHT4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2KHT4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PAPOLB.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129333EBI-10239244,EBI-355744

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123647, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q2KHT4, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405032

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GSG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182927

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q2KHT4

Identification of Orthologs from Complete Genome Data

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OMAi
QYSWEAG

Database of Orthologous Groups

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OrthoDBi
957556at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2KHT4

TreeFam database of animal gene trees

More...
TreeFami
TF331388

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012478 GSG-1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07803 GSG-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2KHT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKMELSKAF SGQRTLLSAI LSMLSLSFST TSLLSNYWFV GTQKVPKPLC
60 70 80 90 100
EKGLAAKCFD MPVSLDGDTN TSTQEVVQYN WETGDDRFSF RSFRSGMWLS
110 120 130 140 150
CEETVEEPAL LHPQSWKQFR ALRSSGTAAA KGERCRSFIE LTPPAKREIL
160 170 180 190 200
WLSLGTQITY IGLQFISFLL LLTDLLLTGN PACGLKLSAF AAVSSVLSGL
210 220 230 240 250
LGMVAHMMYS QVFQATVNLG PEDWRPHVWN YGWAFYMAWL SFTCCMASAV
260 270 280 290 300
TTFNTYTRMV LEFKCKHSKS FKENPNCLPH HHQCFPRRLS SAAPTVGPLT
310 320 330 340
SYHQYHNQPI HSVSEGVDFY SELRNKGFQR GASQELKEAV RSSVEEEQC
Length:349
Mass (Da):39,248
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72AB9D98344023B5
GO
Isoform 2 (identifier: Q2KHT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-198: Missing.

Show »
Length:298
Mass (Da):33,840
Checksum:i0CB417944048E315
GO
Isoform 3 (identifier: Q2KHT4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-131: Missing.

Show »
Length:326
Mass (Da):36,741
Checksum:iF5AA8020EDE0FDB0
GO
Isoform 4 (identifier: Q2KHT4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-131: Missing.
     148-349: EILWLSLGTQ...VRSSVEEEQC → GEKGLLEFAT...QDGAGVQVQA

Show »
Length:285
Mass (Da):31,433
Checksum:i639013F67BC7F765
GO
Isoform 5 (identifier: Q2KHT4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-131: Missing.
     148-198: Missing.

Show »
Length:275
Mass (Da):31,333
Checksum:iB16F6063537A40F3
GO
Isoform 6 (identifier: Q2KHT4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAK → MSDPSQLTQNVCLTQE
     109-131: Missing.

Show »
Length:339
Mass (Da):38,187
Checksum:i5C9479746CB61CE1
GO
Isoform 7 (identifier: Q2KHT4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAK → MSDPSQLTQNVCLTQE
     148-349: EILWLSLGTQ...VRSSVEEEQC → GEKGLLEFAT...VQVQPPPWVL

Show »
Length:326
Mass (Da):36,004
Checksum:iAE22B4CA249971CD
GO
Isoform 8 (identifier: Q2KHT4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-131: Missing.
     148-280: EILWLSLGTQ...FKENPNCLPH → GEKGLLEFAT...GVGCHHLQHV

Show »
Length:343
Mass (Da):38,155
Checksum:iF71938F7435C3FC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H134F5H134_HUMAN
Germ cell-specific gene 1 protein
GSG1
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XAB9G3XAB9_HUMAN
Germ cell associated 1, isoform CRA...
GSG1 hCG_28221
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0V9F5H0V9_HUMAN
Germ cell-specific gene 1 protein
GSG1
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYH0F5GYH0_HUMAN
Germ cell-specific gene 1 protein
GSG1
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0G6A0A494C0G6_HUMAN
Germ cell-specific gene 1 protein
GSG1
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01796 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33854 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32S → P in BAC11548 (PubMed:14702039).Curated1
Sequence conflicti259M → V in BAC11540 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04268439F → L1 PublicationCorresponds to variant dbSNP:rs2306765Ensembl.1
Natural variantiVAR_04268567G → V. Corresponds to variant dbSNP:rs11546332Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329921 – 3MAK → MSDPSQLTQNVCLTQE in isoform 6 and isoform 7. 2 Publications3
Alternative sequenceiVSP_032993109 – 131Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_032994148 – 349EILWL…EEEQC → GEKGLLEFATLQGPCHPTLR FGGKRLMEKASLPSPPLGLC GKNPMVIPGNADHLHRTSIH QLPPATNRLATHWEPCLWAQ TERLCCCFLCPVRSPGDGGP HDVFTSLPSDCQLGSRRLET TCLELWLGLLHGLALLHLLH GVGCHHLQHVHQDGAGVQVQ A in isoform 4. 3 PublicationsAdd BLAST202
Alternative sequenceiVSP_032995148 – 349EILWL…EEEQC → GEKGLLEFATLQGPCHPTLR FGGKRLMEKASLPSPPLGLC GKNPMVIPGNADHLHRTSIH QLPPATNRLATHWEPCLWAQ TERLCCCFLCPVRSPGDGGP HDVFTSLPSDCQLGSRRLET TCLELWLGLLHGLALLHLLH GVGCHHLQHVHQDGAGVQVQ PPPWVL in isoform 7. 1 PublicationAdd BLAST202
Alternative sequenceiVSP_032996148 – 280EILWL…NCLPH → GEKGLLEFATLQGPCHPTLR FGGKRLMEKASLPSPPLGLC GKNPMVIPGNADHLHRTSTH QLPPATNRLATHWEPCLWAQ TERLCCCFLCPVRSPGDGGP HDVFTSLPSDCQLGSRRLET TCLELWLGLLHGLALLHLLH GVGCHHLQHV in isoform 8. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_032997148 – 198Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358513 mRNA Translation: AAQ88877.1
AK027894 mRNA Translation: BAB55437.1
AK058045 mRNA Translation: BAB71638.1
AK075288 mRNA Translation: BAC11524.1
AK075311 mRNA Translation: BAC11540.1
AK075322 mRNA Translation: BAC11548.1
AC023790 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96299.1
BC001796 mRNA Translation: AAH01796.1 Different initiation.
BC033854 mRNA Translation: AAH33854.1 Different initiation.
BC112896 mRNA Translation: AAI12897.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44835.1 [Q2KHT4-3]
CCDS55806.1 [Q2KHT4-5]
CCDS55807.1 [Q2KHT4-2]
CCDS55808.1 [Q2KHT4-6]
CCDS8659.2 [Q2KHT4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001074023.1, NM_001080554.2
NP_001193771.1, NM_001206842.1 [Q2KHT4-6]
NP_001193772.1, NM_001206843.1 [Q2KHT4-2]
NP_001193774.1, NM_001206845.1 [Q2KHT4-5]
NP_112579.2, NM_031289.3 [Q2KHT4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337630; ENSP00000336816; ENSG00000111305 [Q2KHT4-3]
ENST00000396302; ENSP00000379596; ENSG00000111305 [Q2KHT4-4]
ENST00000432710; ENSP00000405032; ENSG00000111305 [Q2KHT4-6]
ENST00000457134; ENSP00000398384; ENSG00000111305 [Q2KHT4-5]
ENST00000537302; ENSP00000441718; ENSG00000111305 [Q2KHT4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83445

UCSC genome browser

More...
UCSCi
uc001rbj.4 human [Q2KHT4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358513 mRNA Translation: AAQ88877.1
AK027894 mRNA Translation: BAB55437.1
AK058045 mRNA Translation: BAB71638.1
AK075288 mRNA Translation: BAC11524.1
AK075311 mRNA Translation: BAC11540.1
AK075322 mRNA Translation: BAC11548.1
AC023790 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96299.1
BC001796 mRNA Translation: AAH01796.1 Different initiation.
BC033854 mRNA Translation: AAH33854.1 Different initiation.
BC112896 mRNA Translation: AAI12897.1
CCDSiCCDS44835.1 [Q2KHT4-3]
CCDS55806.1 [Q2KHT4-5]
CCDS55807.1 [Q2KHT4-2]
CCDS55808.1 [Q2KHT4-6]
CCDS8659.2 [Q2KHT4-4]
RefSeqiNP_001074023.1, NM_001080554.2
NP_001193771.1, NM_001206842.1 [Q2KHT4-6]
NP_001193772.1, NM_001206843.1 [Q2KHT4-2]
NP_001193774.1, NM_001206845.1 [Q2KHT4-5]
NP_112579.2, NM_031289.3 [Q2KHT4-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123647, 3 interactors
IntActiQ2KHT4, 8 interactors
STRINGi9606.ENSP00000405032

Protein family/group databases

TCDBi8.A.16.5.1 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

PTM databases

PhosphoSitePlusiQ2KHT4

Polymorphism and mutation databases

BioMutaiGSG1
DMDMi187471163

Proteomic databases

jPOSTiQ2KHT4
PeptideAtlasiQ2KHT4
PRIDEiQ2KHT4
ProteomicsDBi61312
61313 [Q2KHT4-2]
61314 [Q2KHT4-3]
61315 [Q2KHT4-4]
61316 [Q2KHT4-5]
61317 [Q2KHT4-6]
61318 [Q2KHT4-7]
61319 [Q2KHT4-8]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
83445
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337630; ENSP00000336816; ENSG00000111305 [Q2KHT4-3]
ENST00000396302; ENSP00000379596; ENSG00000111305 [Q2KHT4-4]
ENST00000432710; ENSP00000405032; ENSG00000111305 [Q2KHT4-6]
ENST00000457134; ENSP00000398384; ENSG00000111305 [Q2KHT4-5]
ENST00000537302; ENSP00000441718; ENSG00000111305 [Q2KHT4-2]
GeneIDi83445
KEGGihsa:83445
UCSCiuc001rbj.4 human [Q2KHT4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83445

GeneCards: human genes, protein and diseases

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GeneCardsi
GSG1
HGNCiHGNC:19716 GSG1
neXtProtiNX_Q2KHT4
OpenTargetsiENSG00000111305
PharmGKBiPA134868096

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00950000182927
InParanoidiQ2KHT4
OMAiQYSWEAG
OrthoDBi957556at2759
PhylomeDBiQ2KHT4
TreeFamiTF331388

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSG1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83445

Protein Ontology

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PROi
PR:Q2KHT4

Gene expression databases

BgeeiENSG00000111305 Expressed in 68 organ(s), highest expression level in right testis
ExpressionAtlasiQ2KHT4 baseline and differential
GenevisibleiQ2KHT4 HS

Family and domain databases

InterProiView protein in InterPro
IPR012478 GSG-1
PfamiView protein in Pfam
PF07803 GSG-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2KHT4
Secondary accession number(s): Q8N4M3
, Q8NBR4, Q8NBS0, Q8NBT1, Q96LP9, Q96SI6, Q9BUY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 8, 2019
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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