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Entry version 112 (07 Apr 2021)
Sequence version 2 (06 Feb 2007)
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Protein

Protein CLEC16A

Gene

CLEC16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.1 Publication

Caution

Despite its name, does not contain a C-type lectin domain.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q2KHT3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CLEC16ACurated
Alternative name(s):
C-type lectin domain family 16 member AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLEC16AImported
Synonyms:KIAA0350
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29013, CLEC16A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611303, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2KHT3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000038532.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, insulin-dependent (IDDM)2 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry. Three common non-coding variants of CLEC16A in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). The non-coding variant rs12708716 is associated with reduced expression of CLEC16A in beta cells and reduced beta cell function (PubMed:24949970).2 Publications
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
23274
MIMi222100, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000038532

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2KHT3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLEC16A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125950459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744761 – 1053Protein CLEC16AAdd BLAST1053

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2KHT3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2KHT3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q2KHT3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2KHT3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2KHT3

PeptideAtlas

More...
PeptideAtlasi
Q2KHT3

PRoteomics IDEntifications database

More...
PRIDEi
Q2KHT3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61309 [Q2KHT3-1]
61310 [Q2KHT3-2]
61311 [Q2KHT3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2KHT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2KHT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000038532, Expressed in testis and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2KHT3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2KHT3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000038532, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF41/NRDP1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116875, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q2KHT3, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387122

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2KHT3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 198FPLSequence analysisAdd BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi892 – 933Ser-richAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLEC16A/gop-1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2219, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000013826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007413_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2KHT3

Identification of Orthologs from Complete Genome Data

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OMAi
GFGEPNE

Database of Orthologous Groups

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OrthoDBi
1319544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2KHT3

TreeFam database of animal gene trees

More...
TreeFami
TF314293

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039272, CLEC16A/TT9
IPR019155, CLEC16A/TT9_N

The PANTHER Classification System

More...
PANTHERi
PTHR21481, PTHR21481, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09758, FPL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2KHT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGRSRSWVG GGHGKTSRNI HSLDHLKYLY HVLTKNTTVT EQNRNLLVET
60 70 80 90 100
IRSITEILIW GDQNDSSVFD FFLEKNMFVF FLNILRQKSG RYVCVQLLQT
110 120 130 140 150
LNILFENISH ETSLYYLLSN NYVNSIIVHK FDFSDEEIMA YYISFLKTLS
160 170 180 190 200
LKLNNHTVHF FYNEHTNDFA LYTEAIKFFN HPESMVRIAV RTITLNVYKV
210 220 230 240 250
SLDNQAMLHY IRDKTAVPYF SNLVWFIGSH VIELDDCVQT DEEHRNRGKL
260 270 280 290 300
SDLVAEHLDH LHYLNDILII NCEFLNDVLT DHLLNRLFLP LYVYSLENQD
310 320 330 340 350
KGGERPKISL PVSLYLLSQV FLIIHHAPLV NSLAEVILNG DLSEMYAKTE
360 370 380 390 400
QDIQRSSAKP SIRCFIKPTE TLERSLEMNK HKGKRRVQKR PNYKNVGEEE
410 420 430 440 450
DEEKGPTEDA QEDAEKAKGT EGGSKGIKTS GESEEIEMVI MERSKLSELA
460 470 480 490 500
ASTSVQEQNT TDEEKSAAAT CSESTQWSRP FLDMVYHALD SPDDDYHALF
510 520 530 540 550
VLCLLYAMSH NKGMDPEKLE RIQLPVPNAA EKTTYNHPLA ERLIRIMNNA
560 570 580 590 600
AQPDGKIRLA TLELSCLLLK QQVLMSAGCI MKDVHLACLE GAREESVHLV
610 620 630 640 650
RHFYKGEDIF LDMFEDEYRS MTMKPMNVEY LMMDASILLP PTGTPLTGID
660 670 680 690 700
FVKRLPCGDV EKTRRAIRVF FMLRSLSLQL RGEPETQLPL TREEDLIKTD
710 720 730 740 750
DVLDLNNSDL IACTVITKDG GMVQRFLAVD IYQMSLVEPD VSRLGWGVVK
760 770 780 790 800
FAGLLQDMQV TGVEDDSRAL NITIHKPASS PHSKPFPILQ ATFIFSDHIR
810 820 830 840 850
CIIAKQRLAK GRIQARRMKM QRIAALLDLP IQPTTEVLGF GLGSSTSTQH
860 870 880 890 900
LPFRFYDQGR RGSSDPTVQR SVFASVDKVP GFAVAQCINQ HSSPSLSSQS
910 920 930 940 950
PPSASGSPSG SGSTSHCDSG GTSSSSTPST AQSPADAPMS PELPKPHLPD
960 970 980 990 1000
QLVIVNETEA DSKPSKNVAR SAAVETASLS PSLVPARQPT ISLLCEDTAD
1010 1020 1030 1040 1050
TLSVESLTLV PPVDPHSLRS LTGMPPLSTP AAACTEPVGE EAACAEPVGT

AED
Length:1,053
Mass (Da):117,715
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89DE7C0AE228B0D9
GO
Isoform 2 (identifier: Q2KHT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-202: Missing.
     419-434: Missing.
     882-924: FAVAQCINQH...SHCDSGGTSS → EPAPRPAPQL...KPRRLAAPAS
     925-1053: Missing.

Show »
Length:906
Mass (Da):103,547
Checksum:i072711CE4700B2A1
GO
Isoform 3 (identifier: Q2KHT3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-913: Missing.
     914-935: TSHCDSGGTSSSSTPSTAQSPA → MAATGFSAPNGSCHGTSRTVNS

Show »
Length:140
Mass (Da):14,283
Checksum:i7623A0791B10A774
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXG1H7BXG1_HUMAN
Protein CLEC16A
CLEC16A
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZI2H7BZI2_HUMAN
Protein CLEC16A
CLEC16A
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZJ9H7BZJ9_HUMAN
Protein CLEC16A
CLEC16A
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDG4A0A2R8YDG4_HUMAN
Protein CLEC16A
CLEC16A
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20807 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030288906G → E. Corresponds to variant dbSNP:rs2241100Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0227451 – 913Missing in isoform 3. 1 PublicationAdd BLAST913
Alternative sequenceiVSP_022746201 – 202Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_022747419 – 434Missing in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_022748882 – 924FAVAQ…GGTSS → EPAPRPAPQLVHHGGRSRSF SLWSLCELPFLSQKPRRLAA PAS in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_022749914 – 935TSHCD…AQSPA → MAATGFSAPNGSCHGTSRTV NS in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_022750925 – 1053Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002348 mRNA Translation: BAA20807.3 Different initiation.
AK126771 mRNA No translation available.
BC112897 mRNA Translation: AAI12898.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45409.1 [Q2KHT3-1]
CCDS58423.1 [Q2KHT3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001230332.1, NM_001243403.1 [Q2KHT3-2]
NP_056041.1, NM_015226.2 [Q2KHT3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409552; ENSP00000386495; ENSG00000038532 [Q2KHT3-2]
ENST00000409790; ENSP00000387122; ENSG00000038532 [Q2KHT3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23274

UCSC genome browser

More...
UCSCi
uc002dan.5, human [Q2KHT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002348 mRNA Translation: BAA20807.3 Different initiation.
AK126771 mRNA No translation available.
BC112897 mRNA Translation: AAI12898.1
CCDSiCCDS45409.1 [Q2KHT3-1]
CCDS58423.1 [Q2KHT3-2]
RefSeqiNP_001230332.1, NM_001243403.1 [Q2KHT3-2]
NP_056041.1, NM_015226.2 [Q2KHT3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116875, 14 interactors
IntActiQ2KHT3, 5 interactors
STRINGi9606.ENSP00000387122

PTM databases

iPTMnetiQ2KHT3
PhosphoSitePlusiQ2KHT3

Genetic variation databases

BioMutaiCLEC16A
DMDMi125950459

Proteomic databases

EPDiQ2KHT3
jPOSTiQ2KHT3
MassIVEiQ2KHT3
MaxQBiQ2KHT3
PaxDbiQ2KHT3
PeptideAtlasiQ2KHT3
PRIDEiQ2KHT3
ProteomicsDBi61309 [Q2KHT3-1]
61310 [Q2KHT3-2]
61311 [Q2KHT3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24665, 215 antibodies

Genome annotation databases

EnsembliENST00000409552; ENSP00000386495; ENSG00000038532 [Q2KHT3-2]
ENST00000409790; ENSP00000387122; ENSG00000038532 [Q2KHT3-1]
GeneIDi23274
KEGGihsa:23274
UCSCiuc002dan.5, human [Q2KHT3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23274
DisGeNETi23274

GeneCards: human genes, protein and diseases

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GeneCardsi
CLEC16A
HGNCiHGNC:29013, CLEC16A
HPAiENSG00000038532, Low tissue specificity
MIMi222100, phenotype
611303, gene
neXtProtiNX_Q2KHT3
OpenTargetsiENSG00000038532
PharmGKBiPA162382340
VEuPathDBiHostDB:ENSG00000038532.14

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2219, Eukaryota
GeneTreeiENSGT00390000013826
HOGENOMiCLU_007413_1_0_1
InParanoidiQ2KHT3
OMAiGFGEPNE
OrthoDBi1319544at2759
PhylomeDBiQ2KHT3
TreeFamiTF314293

Enzyme and pathway databases

PathwayCommonsiQ2KHT3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23274, 11 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLEC16A, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLEC16A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23274
PharosiQ2KHT3, Tbio

Protein Ontology

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PROi
PR:Q2KHT3
RNActiQ2KHT3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000038532, Expressed in testis and 185 other tissues
ExpressionAtlasiQ2KHT3, baseline and differential
GenevisibleiQ2KHT3, HS

Family and domain databases

InterProiView protein in InterPro
IPR039272, CLEC16A/TT9
IPR019155, CLEC16A/TT9_N
PANTHERiPTHR21481, PTHR21481, 1 hit
PfamiView protein in Pfam
PF09758, FPL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCL16A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2KHT3
Secondary accession number(s): O15058, Q6ZTB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 7, 2021
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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