UniProtKB - Q2KHN1 (RN151_HUMAN)

BLAST

>sp|Q2KHN1|RN151_HUMAN RING finger protein 151 OS=Homo sapiens OX=9606 GN=RNF151 PE=1 SV=1
MGGGYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQKTCPCCRKE
VKRKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTS
QVPRGTLAEHRQHCQQGSQQRCPLGCGATLDPAERARHNCYRELHNAWSVRQERRRPLLL
SLLRRVRWLDQATSVVRRELAELSNFLEEDTALLEGAPQEEAEAAPEGNVGAEVVGEPRA
NIPCK

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History
Entry version 107 (07 Nov 2018)
Sequence version 1 (07 Mar 2006)
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Protein

RING finger protein 151

Gene

RNF151

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in acrosome formation of spermatids.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	20 – 58	RING-typePROSITE-ProRule annotationAdd BLAST		39
Zinc fingerⁱ	101 – 156	TRAF-typePROSITE-ProRule annotationAdd BLAST		56

GO - Molecular functionⁱ

zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation, Spermatogenesis
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RING finger protein 151
Gene namesⁱ	Name:RNF151
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179580.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23235 RNF151
neXtProtⁱ	NX_Q2KHN1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000179580
PharmGKBⁱ	PA134992556

Polymorphism and mutation databases

BioMutaⁱ	RNF151
DMDMⁱ	119371030

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000255254	1 – 245	RING finger protein 151Add BLAST		245

Proteomic databases

PaxDbⁱ	Q2KHN1
PeptideAtlas More...PeptideAtlasⁱ	Q2KHN1
PRIDEⁱ	Q2KHN1
ProteomicsDBⁱ	61304

PTM databases

iPTMnetⁱ	Q2KHN1
PhosphoSitePlusⁱ	Q2KHN1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179580 Expressed in 75 organ(s), highest expression level in right testis
CleanExⁱ	HS_RNF151
ExpressionAtlasⁱ	Q2KHN1 baseline and differential
Genevisibleⁱ	Q2KHN1 HS

Interactionⁱ

Subunit structureⁱ

Interacts with DTNBP1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NKAPD1	Q6ZUT1	4	EBI-12002474,EBI-3920396

With

Entry

#Exp.

IntAct

Notes

NKAPD1

Q6ZUT1

EBI-12002474,EBI-3920396

Protein-protein interaction databases

BioGridⁱ	126977, 57 interactors
IntActⁱ	Q2KHN1, 15 interactors
STRINGⁱ	9606.ENSP00000456566

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2KHN1
SMRⁱ	Q2KHN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	20 – 58	RING-typePROSITE-ProRule annotationAdd BLAST		39
Zinc fingerⁱ	101 – 156	TRAF-typePROSITE-ProRule annotationAdd BLAST		56

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410KDGV Eukaryota ENOG4111KUV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063647
HOGENOMⁱ	HOG000154154
HOVERGENⁱ	HBG087956
InParanoidⁱ	Q2KHN1
OMAⁱ	CKKCILQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NOP
PhylomeDBⁱ	Q2KHN1
TreeFamⁱ	TF351947

Family and domain databases

Gene3Dⁱ	3.30.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR008974 TRAF-like IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS IPR013010 Znf_SIAH IPR001293 Znf_TRAF
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit PS51081 ZF_SIAH, 1 hit PS50145 ZF_TRAF, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q2KHN1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR 
        60         70         80         90        100
QKTCPCCRKE VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK 
       110        120        130        140        150
GHQDSCPFEL TACPNEGCTS QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL 
       160        170        180        190        200
DPAERARHNC YRELHNAWSV RQERRRPLLL SLLRRVRWLD QATSVVRREL 
       210        220        230        240 
AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA NIPCK

Length:245

Mass (Da):27,412

Last modified:March 7, 2006 - v1

Checksum:ⁱD96AF6A1B7DDD755

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DFQ4	A0A0C4DFQ4_HUMAN	RING finger protein 151 RING finger protein 151	RNF151	244	Annotation score:
H3BNJ8	H3BNJ8_HUMAN	RING finger protein 151 RING finger protein 151	RNF151	90	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC029501 mRNA Translation: AAH29501.2 BC113014 mRNA Translation: AAI13015.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58405.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001335640.1, NM_001348711.1 NP_777563.2, NM_174903.5
UniGeneⁱ	Hs.99354

Genome annotation databases

Ensemblⁱ	ENST00000569714; ENSP00000456566; ENSG00000179580
GeneIDⁱ	146310
KEGGⁱ	hsa:146310
UCSC genome browser More...UCSCⁱ	uc002cnt.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q2KHN1	Uncharacterized protein		CERAT		291	UniRef90_Q2KHN1
Ring finger protein 151		PANTR		246
Uncharacterized protein		MACMU		245
Uncharacterized protein		PAPAN		245
Uncharacterized protein		MACFA		245
+21

Protein	Similar proteins		Species	Score	Length	Source
Q2KHN1	RING finger protein 151		MOUSE		239	UniRef50_Q9CQ29
RING finger protein 151		BOVIN		240
Ring finger protein 151		RAT		238
RING finger protein 151		MYODS		263
Uncharacterized protein		MYOLU		249
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC029501 mRNA Translation: AAH29501.2 BC113014 mRNA Translation: AAI13015.1
CCDSⁱ	CCDS58405.1
RefSeqⁱ	NP_001335640.1, NM_001348711.1 NP_777563.2, NM_174903.5
UniGeneⁱ	Hs.99354

3D structure databases

ProteinModelPortalⁱ	Q2KHN1
SMRⁱ	Q2KHN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126977, 57 interactors
IntActⁱ	Q2KHN1, 15 interactors
STRINGⁱ	9606.ENSP00000456566

PTM databases

iPTMnetⁱ	Q2KHN1
PhosphoSitePlusⁱ	Q2KHN1

Polymorphism and mutation databases

BioMutaⁱ	RNF151
DMDMⁱ	119371030

Proteomic databases

PaxDbⁱ	Q2KHN1
PeptideAtlasⁱ	Q2KHN1
PRIDEⁱ	Q2KHN1
ProteomicsDBⁱ	61304

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000569714; ENSP00000456566; ENSG00000179580
GeneIDⁱ	146310
KEGGⁱ	hsa:146310
UCSCⁱ	uc002cnt.1 human

Organism-specific databases

CTDⁱ	146310
EuPathDBⁱ	HostDB:ENSG00000179580.9
GeneCardsⁱ	RNF151
HGNCⁱ	HGNC:23235 RNF151
neXtProtⁱ	NX_Q2KHN1
OpenTargetsⁱ	ENSG00000179580
PharmGKBⁱ	PA134992556
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KDGV Eukaryota ENOG4111KUV LUCA
GeneTreeⁱ	ENSGT00530000063647
HOGENOMⁱ	HOG000154154
HOVERGENⁱ	HBG087956
InParanoidⁱ	Q2KHN1
OMAⁱ	CKKCILQ
OrthoDBⁱ	EOG091G0NOP
PhylomeDBⁱ	Q2KHN1
TreeFamⁱ	TF351947

Miscellaneous databases

GenomeRNAiⁱ	146310
Protein Ontology More...PROⁱ	PR:Q2KHN1

Gene expression databases

Bgeeⁱ	ENSG00000179580 Expressed in 75 organ(s), highest expression level in right testis
CleanExⁱ	HS_RNF151
ExpressionAtlasⁱ	Q2KHN1 baseline and differential
Genevisibleⁱ	Q2KHN1 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR008974 TRAF-like IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS IPR013010 Znf_SIAH IPR001293 Znf_TRAF
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit PS51081 ZF_SIAH, 1 hit PS50145 ZF_TRAF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RN151_HUMAN
Accessionⁱ	Q2KHN1Primary (citable) accession number: Q2KHN1 Secondary accession number(s): Q8NHS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	March 7, 2006
	Last modified:	November 7, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q2KHN1 (RN151_HUMAN)

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RING finger protein 151

RNF151

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ