UniProtKB - Q2KHN1 (RN151_HUMAN)
Protein
RING finger protein 151
Gene
RNF151
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in acrosome formation of spermatids.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 20 – 58 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 | |
Zinc fingeri | 101 – 156 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- protein ubiquitination Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q2KHN1 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 151 |
Gene namesi | Name:RNF151 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179580.9 |
HGNCi | HGNC:23235, RNF151 |
neXtProti | NX_Q2KHN1 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000179580 |
PharmGKBi | PA134992556 |
Miscellaneous databases
Pharosi | Q2KHN1, Tdark |
Polymorphism and mutation databases
BioMutai | RNF151 |
DMDMi | 119371030 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000255254 | 1 – 245 | RING finger protein 151Add BLAST | 245 |
Proteomic databases
PaxDbi | Q2KHN1 |
PeptideAtlasi | Q2KHN1 |
PRIDEi | Q2KHN1 |
ProteomicsDBi | 61304 |
PTM databases
iPTMneti | Q2KHN1 |
PhosphoSitePlusi | Q2KHN1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179580, Expressed in right testis and 91 other tissues |
ExpressionAtlasi | Q2KHN1, baseline and differential |
Genevisiblei | Q2KHN1, HS |
Organism-specific databases
HPAi | ENSG00000179580, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with DTNBP1.
By similarityBinary interactionsi
Hide detailsQ2KHN1
Protein-protein interaction databases
BioGRIDi | 126977, 73 interactors |
IntActi | Q2KHN1, 15 interactors |
STRINGi | 9606.ENSP00000456566 |
Miscellaneous databases
RNActi | Q2KHN1, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 20 – 58 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 | |
Zinc fingeri | 101 – 156 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 56 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00530000063647 |
InParanoidi | Q2KHN1 |
OMAi | NFLCSVC |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q2KHN1 |
TreeFami | TF351947 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR008974, TRAF-like IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR013010, Znf_SIAH IPR001293, Znf_TRAF |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
SUPFAMi | SSF49599, SSF49599, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS51081, ZF_SIAH, 1 hit PS50145, ZF_TRAF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q2KHN1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR
60 70 80 90 100
QKTCPCCRKE VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK
110 120 130 140 150
GHQDSCPFEL TACPNEGCTS QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL
160 170 180 190 200
DPAERARHNC YRELHNAWSV RQERRRPLLL SLLRRVRWLD QATSVVRREL
210 220 230 240
AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA NIPCK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFQ4 | A0A0C4DFQ4_HUMAN | RING finger protein 151 | RNF151 | 244 | Annotation score: | ||
H3BNJ8 | H3BNJ8_HUMAN | RING finger protein 151 | RNF151 | 90 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC029501 mRNA Translation: AAH29501.2 BC113014 mRNA Translation: AAI13015.1 |
CCDSi | CCDS58405.1 |
RefSeqi | NP_001335640.1, NM_001348711.1 NP_777563.2, NM_174903.5 |
Genome annotation databases
Ensembli | ENST00000569714; ENSP00000456566; ENSG00000179580 |
GeneIDi | 146310 |
KEGGi | hsa:146310 |
UCSCi | uc002cnt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC029501 mRNA Translation: AAH29501.2 BC113014 mRNA Translation: AAI13015.1 |
CCDSi | CCDS58405.1 |
RefSeqi | NP_001335640.1, NM_001348711.1 NP_777563.2, NM_174903.5 |
3D structure databases
SMRi | Q2KHN1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126977, 73 interactors |
IntActi | Q2KHN1, 15 interactors |
STRINGi | 9606.ENSP00000456566 |
PTM databases
iPTMneti | Q2KHN1 |
PhosphoSitePlusi | Q2KHN1 |
Polymorphism and mutation databases
BioMutai | RNF151 |
DMDMi | 119371030 |
Proteomic databases
PaxDbi | Q2KHN1 |
PeptideAtlasi | Q2KHN1 |
PRIDEi | Q2KHN1 |
ProteomicsDBi | 61304 |
Protocols and materials databases
Antibodypediai | 23363, 26 antibodies |
Genome annotation databases
Ensembli | ENST00000569714; ENSP00000456566; ENSG00000179580 |
GeneIDi | 146310 |
KEGGi | hsa:146310 |
UCSCi | uc002cnt.1, human |
Organism-specific databases
CTDi | 146310 |
EuPathDBi | HostDB:ENSG00000179580.9 |
GeneCardsi | RNF151 |
HGNCi | HGNC:23235, RNF151 |
HPAi | ENSG00000179580, Tissue enriched (testis) |
neXtProti | NX_Q2KHN1 |
OpenTargetsi | ENSG00000179580 |
PharmGKBi | PA134992556 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00530000063647 |
InParanoidi | Q2KHN1 |
OMAi | NFLCSVC |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q2KHN1 |
TreeFami | TF351947 |
Enzyme and pathway databases
PathwayCommonsi | Q2KHN1 |
Miscellaneous databases
BioGRID-ORCSi | 146310, 6 hits in 843 CRISPR screens |
GenomeRNAii | 146310 |
Pharosi | Q2KHN1, Tdark |
PROi | PR:Q2KHN1 |
RNActi | Q2KHN1, protein |
Gene expression databases
Bgeei | ENSG00000179580, Expressed in right testis and 91 other tissues |
ExpressionAtlasi | Q2KHN1, baseline and differential |
Genevisiblei | Q2KHN1, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR008974, TRAF-like IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR013010, Znf_SIAH IPR001293, Znf_TRAF |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
SUPFAMi | SSF49599, SSF49599, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS51081, ZF_SIAH, 1 hit PS50145, ZF_TRAF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RN151_HUMAN | |
Accessioni | Q2KHN1Primary (citable) accession number: Q2KHN1 Secondary accession number(s): Q8NHS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM