Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gasdermin-C2

Gene

Gsdmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown.By similarity

GO - Molecular functioni

GO - Biological processi

  • intestinal epithelial cell development Source: UniProtKB
  • pyroptosis Source: GO_Central

Keywordsi

Biological processNecrosis

Names & Taxonomyi

Protein namesi
Recommended name:
Gasdermin-C2
Gene namesi
Name:Gsdmc2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146102 Gsdmc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473311 – 480Gasdermin-C2Add BLAST480

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ2KHK6
PaxDbiQ2KHK6
PRIDEiQ2KHK6

Expressioni

Gene expression databases

BgeeiENSMUSG00000056293 Expressed in 45 organ(s), highest expression level in colon
GenevisibleiQ2KHK6 MM

Interactioni

Subunit structurei

The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 226Triggers pyroptosisBy similarityAdd BLAST226

Domaini

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.By similarity

Sequence similaritiesi

Belongs to the gasdermin family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IVCF Eukaryota
ENOG4111AD5 LUCA
GeneTreeiENSGT00530000063218
HOGENOMiHOG000082450
HOVERGENiHBG107969
InParanoidiQ2KHK6
KOiK22143
OMAiFNQMEET
OrthoDBiEOG091G0MAU
PhylomeDBiQ2KHK6
TreeFamiTF331886

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KHK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGYSFDRASK DVVKKLQGRD LRPVECLSDA TKFRLFHILQ ETPRSGWETE
60 70 80 90 100
DIPVGFTLLD LLEPNFPVPE PEVSAPKPFI HVQSTDLEAN LNVADIARGG
110 120 130 140 150
VGYVGYGGYN IEVQSTSIPN PKLEILQNRK LLDNLPTFMK FCRMERKNLY
160 170 180 190 200
VVTEAYEVSK DTMLTGLSSV NLSVKGFFKQ LFKVRGKAGR SEKYSIPIPK
210 220 230 240 250
GSVLAYKKQQ LVIENNTCVI LPSATKKKMT FPGTPKYASA SEPTEIYRTE
260 270 280 290 300
LQGLWINDIV PIGRIQEPAH LDFMCLQNEV YKQTEQLAEL SKGVQEVVLS
310 320 330 340 350
SILSMLYEGD RKVLYDLMNM LELNQLGHMD GPGGKILDEL RKDSSNPCVD
360 370 380 390 400
LKDLILYLLQ ALMVLSDSQL NLLAQSVEMG ILPHQVELVK SILQPNFKYP
410 420 430 440 450
WNIPFTLQPQ LLAPLQGEGL AITYELLEEC GLKMELNNPR STWDLEAKMP
460 470 480
LSALYGSLSF LQQLRKANSS SKPSLRPGYI
Length:480
Mass (Da):53,952
Last modified:September 2, 2008 - v2
Checksum:iC1F78ECDB8D4AAD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134N → K in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti180Q → H in BAC28384 (PubMed:16141072).Curated1
Sequence conflicti363M → L in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti368S → T in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti371N → C in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti378E → K in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti381I → L in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti395P → T in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti400 – 403PWNI → SSNT in AAI13154 (PubMed:15489334).Curated4
Sequence conflicti407L → V in AAI13156 (PubMed:15489334).Curated1
Sequence conflicti465R → Q in AAI13154 (PubMed:15489334).Curated1
Sequence conflicti476R → S in AAI13154 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033603 mRNA Translation: BAC28384.1
BC113153 mRNA Translation: AAI13154.1
BC113155 mRNA Translation: AAI13156.1
CCDSiCCDS37087.1
RefSeqiNP_001161746.1, NM_001168274.1
NP_808580.2, NM_177912.4
XP_006521159.1, XM_006521096.3
XP_006521160.1, XM_006521097.3
XP_006521161.1, XM_006521098.3
XP_011243969.1, XM_011245667.2
XP_011243970.1, XM_011245668.2
XP_011243971.1, XM_011245669.2
XP_011243972.1, XM_011245670.2
XP_011243973.1, XM_011245671.2
XP_011243974.1, XM_011245672.2
XP_011243975.1, XM_011245673.2
XP_011243976.1, XM_011245674.2
XP_011243977.1, XM_011245675.2
XP_011243978.1, XM_011245676.2
XP_011243979.1, XM_011245677.2
UniGeneiMm.273185
Mm.335611

Genome annotation databases

EnsembliENSMUST00000089900; ENSMUSP00000087344; ENSMUSG00000056293
ENSMUST00000188404; ENSMUSP00000141066; ENSMUSG00000056293
ENSMUST00000188691; ENSMUSP00000140487; ENSMUSG00000056293
GeneIDi331063
KEGGimmu:331063
UCSCiuc007vyu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033603 mRNA Translation: BAC28384.1
BC113153 mRNA Translation: AAI13154.1
BC113155 mRNA Translation: AAI13156.1
CCDSiCCDS37087.1
RefSeqiNP_001161746.1, NM_001168274.1
NP_808580.2, NM_177912.4
XP_006521159.1, XM_006521096.3
XP_006521160.1, XM_006521097.3
XP_006521161.1, XM_006521098.3
XP_011243969.1, XM_011245667.2
XP_011243970.1, XM_011245668.2
XP_011243971.1, XM_011245669.2
XP_011243972.1, XM_011245670.2
XP_011243973.1, XM_011245671.2
XP_011243974.1, XM_011245672.2
XP_011243975.1, XM_011245673.2
XP_011243976.1, XM_011245674.2
XP_011243977.1, XM_011245675.2
XP_011243978.1, XM_011245676.2
XP_011243979.1, XM_011245677.2
UniGeneiMm.273185
Mm.335611

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ2KHK6
PaxDbiQ2KHK6
PRIDEiQ2KHK6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089900; ENSMUSP00000087344; ENSMUSG00000056293
ENSMUST00000188404; ENSMUSP00000141066; ENSMUSG00000056293
ENSMUST00000188691; ENSMUSP00000140487; ENSMUSG00000056293
GeneIDi331063
KEGGimmu:331063
UCSCiuc007vyu.1 mouse

Organism-specific databases

CTDi331063
MGIiMGI:2146102 Gsdmc2

Phylogenomic databases

eggNOGiENOG410IVCF Eukaryota
ENOG4111AD5 LUCA
GeneTreeiENSGT00530000063218
HOGENOMiHOG000082450
HOVERGENiHBG107969
InParanoidiQ2KHK6
KOiK22143
OMAiFNQMEET
OrthoDBiEOG091G0MAU
PhylomeDBiQ2KHK6
TreeFamiTF331886

Miscellaneous databases

PROiPR:Q2KHK6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056293 Expressed in 45 organ(s), highest expression level in colon
GenevisibleiQ2KHK6 MM

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSDC2_MOUSE
AccessioniPrimary (citable) accession number: Q2KHK6
Secondary accession number(s): Q2KHK8, Q8CC94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again